UCKL1 uridine-cytidine kinase 1 like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: UCKL1provided by HGNC
Official Full Name: uridine-cytidine kinase 1 like 1provided by HGNC
Primary source: HGNC:HGNC:15938
See related: Ensembl:ENSG00000198276 MIM:610866; AllianceGenome:HGNC:15938
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UCK1L; URKL1
Summary: The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression: Ubiquitous expression in spleen (RPKM 6.2), ovary (RPKM 4.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.33

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (63939829..63956416, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (65759678..65777377, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (62571182..62587769, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth.
Title: Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth.
The presence of IL28B rs8099917 TT and rs12979860 CC SNPs, but not the intensity of UCKL-1 expression, is strongly associated with increased chances of Hepatocellular Carcinoma development in hepatitis C virus -positive cirrhotic patients.
Title: Impact of the Uridine⁻Cytidine Kinase Like-1 Protein and IL28B rs12979860 and rs8099917 SNPs on the Development of Hepatocellular Carcinoma in Cirrhotic Chronic Hepatitis C Patients-A Pilot Study.
These results indicate a role for UCKL-1 in tumor cell survival.
Title: Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_26200-26201:1030734098:1 (e-PCR)
- UniSTS:268983

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytidine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables uridine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in CMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CTP salvage	IEA Inferred from Electronic Annotation more info
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleoside salvage	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uridine-cytidine kinase-like 1

Names: UCK1-LIKE

NP_001180308.1

EC 2.7.1.48

NP_001340404.1

EC 2.7.1.48

NP_001340405.1

EC 2.7.1.48

NP_001340406.1

EC 2.7.1.48

NP_001340407.1

EC 2.7.1.48

NP_001340408.1

EC 2.7.1.48

NP_001340409.1

EC 2.7.1.48

NP_001340410.1

EC 2.7.1.48

NP_001340411.1

EC 2.7.1.48

NP_060329.2

EC 2.7.1.48

XP_005260273.1

EC 2.7.1.48

XP_006723869.1

EC 2.7.1.48

XP_006723870.1

EC 2.7.1.48

XP_006723872.1

EC 2.7.1.48

XP_016883383.1

EC 2.7.1.48

XP_047296182.1

EC 2.7.1.48

XP_047296183.1

EC 2.7.1.48

XP_047296184.1

EC 2.7.1.48

XP_047296185.1

EC 2.7.1.48

XP_047296186.1

EC 2.7.1.48

XP_047296187.1

EC 2.7.1.48

XP_047296188.1

EC 2.7.1.48

XP_047296189.1

EC 2.7.1.48

XP_047296190.1

EC 2.7.1.48

XP_047296191.1

EC 2.7.1.48

XP_047296192.1

EC 2.7.1.48

XP_047296193.1

EC 2.7.1.48

XP_047296194.1

EC 2.7.1.48

XP_047296195.1

EC 2.7.1.48

XP_047296196.1

EC 2.7.1.48

XP_047296197.1

EC 2.7.1.48

XP_047296198.1

EC 2.7.1.48

XP_047296199.1

EC 2.7.1.48

XP_047296200.1

EC 2.7.1.48

XP_054179532.1

EC 2.7.1.48

XP_054179533.1

EC 2.7.1.48

XP_054179534.1

EC 2.7.1.48

XP_054179535.1

EC 2.7.1.48

XP_054179536.1

EC 2.7.1.48

XP_054179537.1

EC 2.7.1.48

XP_054179538.1

EC 2.7.1.48

XP_054179539.1

EC 2.7.1.48

XP_054179540.1

EC 2.7.1.48

XP_054179541.1

EC 2.7.1.48

XP_054179542.1

EC 2.7.1.48

XP_054179543.1

EC 2.7.1.48

XP_054179544.1

EC 2.7.1.48

XP_054179545.1

EC 2.7.1.48

XP_054179546.1

EC 2.7.1.48

XP_054179547.1

EC 2.7.1.48

XP_054179548.1

EC 2.7.1.48

XP_054179549.1

EC 2.7.1.48

XP_054179550.1

EC 2.7.1.48

XP_054179551.1

EC 2.7.1.48

XP_054179552.1

EC 2.7.1.48

XP_054179553.1

EC 2.7.1.48

XP_054179554.1

EC 2.7.1.48

XP_054179555.1

EC 2.7.1.48

XP_054179556.1

EC 2.7.1.48

XP_054179557.1

EC 2.7.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193379.2 → NP_001180308.1 uridine-cytidine kinase-like 1 isoform 2

See identical proteins and their annotated locations for NP_001180308.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a different first exon for its 5' UTR and 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.

Source sequence(s)

AK222559, AK303688, AL118506, DC379603

Consensus CDS

CCDS54479.1

UniProtKB/TrEMBL

Q53HM1

Related

ENSP00000358924.5, ENST00000369908.9

Conserved Domains (2) summary

cd02023
Location:86 → 284

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:314 → 517

UPRTase; Uracil phosphoribosyltransferase
NM_001353475.2 → NP_001340404.1 uridine-cytidine kinase-like 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) encodes the longest isoform (3).

Source sequence(s)

AL118506

UniProtKB/TrEMBL

Q53HM1

Conserved Domains (2) summary

cd02023
Location:101 → 299

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:330 → 533

UPRTase; Uracil phosphoribosyltransferase
NM_001353476.2 → NP_001340405.1 uridine-cytidine kinase-like 1 isoform 4

Status: REVIEWED

Source sequence(s)

AL118506

UniProtKB/TrEMBL

Q53HM1

Conserved Domains (2) summary

cd02023
Location:100 → 298

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:329 → 532

UPRTase; Uracil phosphoribosyltransferase
NM_001353477.2 → NP_001340406.1 uridine-cytidine kinase-like 1 isoform 5

Status: REVIEWED

Source sequence(s)

AL118506

UniProtKB/TrEMBL

Q53HM1

Conserved Domains (2) summary

cd02023
Location:100 → 298

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:328 → 531

UPRTase; Uracil phosphoribosyltransferase
NM_001353478.2 → NP_001340407.1 uridine-cytidine kinase-like 1 isoform 6

Status: REVIEWED

Source sequence(s)

AL118506

UniProtKB/TrEMBL

Q53HM1

Conserved Domains (2) summary

cd02023
Location:85 → 283

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:314 → 517

UPRTase; Uracil phosphoribosyltransferase
NM_001353479.2 → NP_001340408.1 uridine-cytidine kinase-like 1 isoform 7

Status: REVIEWED

Source sequence(s)

AL118506

UniProtKB/TrEMBL

Q53HM1

Conserved Domains (2) summary

cd02023
Location:85 → 283

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:313 → 516

UPRTase; Uracil phosphoribosyltransferase
NM_001353480.2 → NP_001340409.1 uridine-cytidine kinase-like 1 isoform 8

Status: REVIEWED

Source sequence(s)

AL118506

Conserved Domains (2) summary

cd02023
Location:20 → 181

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:211 → 414

UPRTase; Uracil phosphoribosyltransferase
NM_001353481.2 → NP_001340410.1 uridine-cytidine kinase-like 1 isoform 9

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variant 11, encodes isoform 9.

Source sequence(s)

AL118506

Conserved Domains (2) summary

pfam14681
Location:121 → 324

UPRTase; Uracil phosphoribosyltransferase

cl17190
Location:1 → 91

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001353482.2 → NP_001340411.1 uridine-cytidine kinase-like 1 isoform 9

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variant 10, encodes isoform 9.

Source sequence(s)

AL118506

Conserved Domains (2) summary

pfam14681
Location:121 → 324

UPRTase; Uracil phosphoribosyltransferase

cl17190
Location:1 → 91

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_017859.4 → NP_060329.2 uridine-cytidine kinase-like 1 isoform 1

See identical proteins and their annotated locations for NP_060329.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AK000524, AK222559, DB193745

Consensus CDS

CCDS13547.1

UniProtKB/Swiss-Prot

B7Z8N2, Q5JWV0, Q70AQ5, Q8N524, Q9H3Z2, Q9NWZ5

UniProtKB/TrEMBL

Q53HM1

Related

ENSP00000346155.6, ENST00000354216.11

Conserved Domains (2) summary

cd02023
Location:101 → 299

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:329 → 532

UPRTase; Uracil phosphoribosyltransferase

RNA

NR_126526.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AJ605558, AK222559, AL118506, DA255371
NR_148434.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL118506
NR_148435.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL118506
NR_148436.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL118506
NR_148437.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL118506
NR_148438.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL118506
NR_148439.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL118506
NR_148440.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL118506
NR_148441.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL118506
NR_148442.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL118506

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

63939829..63956416 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047440228.1 → XP_047296184.1 uridine-cytidine kinase-like 1 isoform X8
XM_047440227.1 → XP_047296183.1 uridine-cytidine kinase-like 1 isoform X5
XM_047440226.1 → XP_047296182.1 uridine-cytidine kinase-like 1 isoform X4
XM_006723809.2 → XP_006723872.1 uridine-cytidine kinase-like 1 isoform X7

UniProtKB/TrEMBL

Q53HM1

Conserved Domains (3) summary

COG0572
Location:93 → 303

Udk; Uridine kinase [Nucleotide transport and metabolism]

cd02023
Location:101 → 299

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:331 → 534

UPRTase; Uracil phosphoribosyltransferase
XM_006723807.3 → XP_006723870.1 uridine-cytidine kinase-like 1 isoform X3

UniProtKB/TrEMBL

Q53HM1

Conserved Domains (2) summary

cd02023
Location:101 → 307

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:338 → 541

UPRTase; Uracil phosphoribosyltransferase
XM_006723806.3 → XP_006723869.1 uridine-cytidine kinase-like 1 isoform X1

UniProtKB/TrEMBL

Q53HM1

Conserved Domains (3) summary

COG0572
Location:93 → 311

Udk; Uridine kinase [Nucleotide transport and metabolism]

cd02023
Location:101 → 307

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:339 → 542

UPRTase; Uracil phosphoribosyltransferase
XM_005260216.3 → XP_005260273.1 uridine-cytidine kinase-like 1 isoform X6

UniProtKB/TrEMBL

Q53HM1

Conserved Domains (2) summary

cd02023
Location:101 → 307

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:337 → 540

UPRTase; Uracil phosphoribosyltransferase
XM_047440232.1 → XP_047296188.1 uridine-cytidine kinase-like 1 isoform X11
XM_047440230.1 → XP_047296186.1 uridine-cytidine kinase-like 1 isoform X10
XM_047440229.1 → XP_047296185.1 uridine-cytidine kinase-like 1 isoform X9
XM_047440231.1 → XP_047296187.1 uridine-cytidine kinase-like 1 isoform X11
XM_047440233.1 → XP_047296189.1 uridine-cytidine kinase-like 1 isoform X12
XM_047440244.1 → XP_047296200.1 uridine-cytidine kinase-like 1 isoform X21
XM_047440243.1 → XP_047296199.1 uridine-cytidine kinase-like 1 isoform X21
XM_047440234.1 → XP_047296190.1 uridine-cytidine kinase-like 1 isoform X13

Related

ENSP00000351546.3, ENST00000358711.7
XM_047440235.1 → XP_047296191.1 uridine-cytidine kinase-like 1 isoform X14
XM_047440236.1 → XP_047296192.1 uridine-cytidine kinase-like 1 isoform X15
XM_047440237.1 → XP_047296193.1 uridine-cytidine kinase-like 1 isoform X16
XM_047440239.1 → XP_047296195.1 uridine-cytidine kinase-like 1 isoform X18
XM_047440240.1 → XP_047296196.1 uridine-cytidine kinase-like 1 isoform X19
XM_047440242.1 → XP_047296198.1 uridine-cytidine kinase-like 1 isoform X20
XM_047440241.1 → XP_047296197.1 uridine-cytidine kinase-like 1 isoform X19
XM_017027894.3 → XP_016883383.1 uridine-cytidine kinase-like 1 isoform X2
XM_047440238.1 → XP_047296194.1 uridine-cytidine kinase-like 1 isoform X17