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    Mphosph9 M-phase phosphoprotein 9 [ Mus musculus (house mouse) ]

    Gene ID: 269702, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mphosph9provided by MGI
    Official Full Name
    M-phase phosphoprotein 9provided by MGI
    Primary source
    MGI:MGI:2443138
    See related
    Ensembl:ENSMUSG00000038126 AllianceGenome:MGI:2443138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPP9; MPP-9; 4930548D04Rik; 9630025B04Rik; B930097C17Rik
    Summary
    Involved in negative regulation of cilium assembly. Located in centrosome. Is expressed in embryo. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MPHOSPH9 (M-phase phosphoprotein 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 4.8), CNS E11.5 (RPKM 4.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mphosph9 in Genome Data Viewer
    Location:
    5 F; 5 63.47 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124389022..124466001, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124250959..124329397, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 2 Neighboring gene STARR-seq mESC enhancer starr_14332 Neighboring gene STARR-positive B cell enhancer ABC_E6381 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:124682259-124682612 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_14333 Neighboring gene mitochondrial translation release factor in rescue Neighboring gene cyclin dependent kinase 2 associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Huang N, et al. Nat Commun, 2018 Oct 30. PMID 30375385, Free PMC Article
    2. A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development. Modzelewski AJ, et al. Cell, 2021 Oct 28. PMID 34644528, Free PMC Article
    3. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MPP9 acts as a regulator of ciliogenesis by regulating the localization of CP110-CEP97 at the mother centriole.
      Title: M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    M-phase phosphoprotein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081323.3 → NP_001074792.1  M-phase phosphoprotein 9 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. This variant lacks full-length transcript support; its exon combination is inferred based on aligning partial transcripts.
      Source sequence(s)
      AC127339, AC164421
      Consensus CDS
      CCDS39277.1
      UniProtKB/Swiss-Prot
      A0A8Q0P9S6, A6H5Y1, E9QPF8, Q8BUK7, Q8BV15, V9GX48
      Related
      ENSMUSP00000031344.7, ENSMUST00000031344.13
      Conserved Domains (2) summary
      pfam01442
      Location:521 → 683
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam15035
      Location:550 → 714
      Rootletin; Ciliary rootlet component, centrosome cohesion

    2. NM_001277867.2 → NP_001264796.1  M-phase phosphoprotein 9 isoform a

      See identical proteins and their annotated locations for NP_001264796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). This variant lacks full-length transcript support; its exon combination is inferred based on aligning partial transcripts and on orthologous alignments.
      Source sequence(s)
      AC127339, AC164421
      Consensus CDS
      CCDS71671.1
      UniProtKB/TrEMBL
      A0A8Q0L6P9
      Related
      ENSMUSP00000138982.2, ENSMUST00000184951.8
      Conserved Domains (1) summary
      COG1196
      Location:556 → 759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_001408187.1 → NP_001395116.1  M-phase phosphoprotein 9 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC127339, AC164421

    4. NM_001408188.1 → NP_001395117.1  M-phase phosphoprotein 9 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC127339, AC164421

    RNA

    1. NR_176470.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127339, AC164421

    2. NR_176471.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127339, AC164421

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124389022..124466001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165156.1 → XP_036021049.1  M-phase phosphoprotein 9 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:556 → 759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:703 → 976
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    2. XM_030254544.1 → XP_030110404.1  M-phase phosphoprotein 9 isoform X5

      Conserved Domains (1) summary
      COG1196
      Location:198 → 383
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006530364.2 → XP_006530427.1  M-phase phosphoprotein 9 isoform X3

      See identical proteins and their annotated locations for XP_006530427.1

      Conserved Domains (2) summary
      COG1196
      Location:398 → 601
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15921
      Location:400 → 849
      CCDC158; Coiled-coil domain-containing protein 158

    4. XM_036165157.1 → XP_036021050.1  M-phase phosphoprotein 9 isoform X5

      Conserved Domains (1) summary
      COG1196
      Location:198 → 383
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_011248205.1 → XP_011246507.1  M-phase phosphoprotein 9 isoform X3

      See identical proteins and their annotated locations for XP_011246507.1

      Conserved Domains (2) summary
      COG1196
      Location:398 → 601
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15921
      Location:400 → 849
      CCDC158; Coiled-coil domain-containing protein 158

    6. XM_011248206.1 → XP_011246508.1  M-phase phosphoprotein 9 isoform X5

      See identical proteins and their annotated locations for XP_011246508.1

      Conserved Domains (1) summary
      COG1196
      Location:198 → 383
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_006530365.3 → XP_006530428.1  M-phase phosphoprotein 9 isoform X4

      Conserved Domains (1) summary
      COG1196
      Location:556 → 759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_004942521.1 RNA Sequence

    2. XR_001784704.2 RNA Sequence

    3. XR_004942522.1 RNA Sequence

    4. XR_878687.2 RNA Sequence

    5. XR_003955654.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6H5Y1.2 GenPept UniProtKB/Swiss-Prot:A6H5Y1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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