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    Vwa5b2 von Willebrand factor A domain containing 5B2 [ Mus musculus (house mouse) ]

    Gene ID: 328643, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Vwa5b2provided by MGI
    Official Full Name
    von Willebrand factor A domain containing 5B2provided by MGI
    Primary source
    MGI:MGI:2681859
    See related
    Ensembl:ENSMUSG00000046613 AllianceGenome:MGI:2681859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm931; Gm1738; EG328644
    Summary
    Is expressed in nervous system; pancreas trunk epithelium; and sensory organ. Orthologous to human VWA5B2 (von Willebrand factor A domain containing 5B2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 10.8), frontal lobe adult (RPKM 7.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vwa5b2 in Genome Data Viewer
    Location:
    16 A3; 16 12.47 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20408174..20424128)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20589428..20605378)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family F member 3 Neighboring gene predicted gene, 20164 Neighboring gene predicted gene, 35685 Neighboring gene microRNA 1224 Neighboring gene STARR-positive B cell enhancer ABC_E10894 Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene ALG3 alpha-1,3- mannosyltransferase Neighboring gene Eef1akmt4-endothelin converting enzyme 2 readthrough

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    2. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC62438, MGC130431, MGC180294, MGC180377

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor A domain-containing protein 5B2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144953.1 → NP_001138425.1  von Willebrand factor A domain-containing protein 5B2 isoform 1

      See identical proteins and their annotated locations for NP_001138425.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC087898, AK045595, AK141799, BE862588, BM950198, BP765893, CA751913
      Consensus CDS
      CCDS49792.1
      UniProtKB/Swiss-Prot
      Q2TB01, Q3UR50, Q80WS8, Q8BR57
      UniProtKB/TrEMBL
      E0CZ01
      Related
      ENSMUSP00000093911.5, ENSMUST00000096197.11
      Conserved Domains (3) summary
      TIGR03788
      Location:36 → 652
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:353 → 501
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. NM_001384104.1 → NP_001371033.1  von Willebrand factor A domain-containing protein 5B2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      E0CZ01
      Conserved Domains (2) summary
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:354 → 501
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. NM_001384105.1 → NP_001371034.1  von Willebrand factor A domain-containing protein 5B2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      E0CZ01
      Conserved Domains (2) summary
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:354 → 501
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    4. NM_182636.4 → NP_872574.2  von Willebrand factor A domain-containing protein 5B2 isoform 2

      See identical proteins and their annotated locations for NP_872574.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternative 3' splice pattern, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC087898
      Consensus CDS
      CCDS37288.1
      UniProtKB/Swiss-Prot
      Q3UR50
      Related
      ENSMUSP00000097652.4, ENSMUST00000100074.10
      Conserved Domains (3) summary
      TIGR03788
      Location:36 → 556
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:353 → 501
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20408174..20424128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249160.2 → XP_030105020.1  von Willebrand factor A domain-containing protein 5B2 isoform X3

      UniProtKB/TrEMBL
      E0CZ01
      Conserved Domains (3) summary
      TIGR03788
      Location:36 → 653
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:354 → 501
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_030249158.2 → XP_030105018.1  von Willebrand factor A domain-containing protein 5B2 isoform X1

      UniProtKB/TrEMBL
      E0CZ01
      Conserved Domains (3) summary
      TIGR03788
      Location:36 → 657
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:358 → 505
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. XM_030249163.2 → XP_030105023.1  von Willebrand factor A domain-containing protein 5B2 isoform X6

      UniProtKB/TrEMBL
      E0CZ01
      Conserved Domains (2) summary
      TIGR03788
      Location:28 → 642
      marine_srt_targ; marine proteobacterial sortase target protein
      cl00057
      Location:343 → 490
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    4. XM_030249164.2 → XP_030105024.1  von Willebrand factor A domain-containing protein 5B2 isoform X7

      UniProtKB/TrEMBL
      E0CZ01
      Conserved Domains (2) summary
      TIGR03788
      Location:28 → 638
      marine_srt_targ; marine proteobacterial sortase target protein
      cl00057
      Location:339 → 486
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    5. XM_006522299.5 → XP_006522362.1  von Willebrand factor A domain-containing protein 5B2 isoform X4

      UniProtKB/TrEMBL
      E0CZ01
      Conserved Domains (3) summary
      TIGR03788
      Location:36 → 657
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:358 → 505
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    6. XM_006522295.5 → XP_006522358.1  von Willebrand factor A domain-containing protein 5B2 isoform X2

      UniProtKB/TrEMBL
      E0CZ01
      Conserved Domains (3) summary
      TIGR03788
      Location:36 → 656
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:358 → 505
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    7. XM_017317053.3 → XP_017172542.1  von Willebrand factor A domain-containing protein 5B2 isoform X5

      UniProtKB/TrEMBL
      E0CZ01
      Conserved Domains (3) summary
      TIGR03788
      Location:36 → 656
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:358 → 505
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    8. XM_030249157.2 → XP_030105017.1  von Willebrand factor A domain-containing protein 5B2 isoform X1

      UniProtKB/TrEMBL
      E0CZ01
      Conserved Domains (3) summary
      TIGR03788
      Location:36 → 657
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:358 → 505
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    9. XM_030249159.2 → XP_030105019.1  von Willebrand factor A domain-containing protein 5B2 isoform X3

      UniProtKB/TrEMBL
      E0CZ01
      Related
      ENSMUSP00000123727.2, ENSMUST00000159780.2
      Conserved Domains (3) summary
      TIGR03788
      Location:36 → 653
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam13757
      Location:2 → 79
      VIT_2; Vault protein inter-alpha-trypsin domain
      cl00057
      Location:354 → 501
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RNA

    1. XR_004939197.1 RNA Sequence

    2. XR_001781838.3 RNA Sequence

    3. XR_001781839.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198629.1: Suppressed sequence

      Description
      NM_198629.1: This RefSeq was permanently suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UR50.2 GenPept UniProtKB/Swiss-Prot:Q3UR50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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