Msi2 musashi RNA-binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Msi2provided by MGI
Official Full Name: musashi RNA-binding protein 2provided by MGI
Primary source: MGI:MGI:1923876
See related: Ensembl:ENSMUSG00000069769 AllianceGenome:MGI:1923876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Msi2h; 1700105C15Rik
Summary: Enables poly(U) RNA binding activity. Involved in stem cell development. Located in cytoplasm. Is expressed in several structures, including central nervous system; gonad; hair follicle; limb bud; and sensory organ. Orthologous to human MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 15.7), whole brain E14.5 (RPKM 15.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 52.4 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (88230208..88609197, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (88339382..88718306, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation.
Title: The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation.
Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
Title: Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
Title: Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
Lack of Musashi-2 induces type IIa fiber-dominated muscle atrophy.
Title: Lack of Musashi-2 induces type IIa fiber-dominated muscle atrophy.
ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.
Title: ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.
Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma.
Title: Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma.
MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota.
Title: MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota.
Msi2-mediated MiR7a-1 processing repression promotes myogenesis.
Title: Msi2-mediated MiR7a-1 processing repression promotes myogenesis.
Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model.
Title: Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model.
Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.
Title: Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Fpm107 (e-PCR)
- UniSTS:510464

AI563628 (e-PCR)
- UniSTS:180289

AW489193 (e-PCR)
- UniSTS:180290

AW743339 (e-PCR)
- UniSTS:208726

AW822009 (e-PCR)
- UniSTS:208727

UniSTS:236694 (e-PCR)
- UniSTS:236694

AI451722 (e-PCR)
- UniSTS:165786

NoName (e-PCR)
- UniSTS:236698

NoName (e-PCR)
- UniSTS:485297

Msi2 (e-PCR), detects polymorphism
- UniSTS:479176

D11Fpm105 (e-PCR)
- UniSTS:510462

D11Fpm106 (e-PCR)
- UniSTS:510463

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(U) RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in stem cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding protein Musashi homolog 2

Names: Musashi2; musashi-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201341.1 → NP_001188270.1 RNA-binding protein Musashi homolog 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents an alternate splice pattern in the 3' coding region and UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL645601

Consensus CDS

CCDS48882.1

UniProtKB/TrEMBL

B1AT13

Related

ENSMUSP00000103541.2, ENSMUST00000107908.2

Conserved Domains (1) summary

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
NM_001363194.1 → NP_001350123.1 RNA-binding protein Musashi homolog 2 isoform 3

Status: VALIDATED

Source sequence(s)

AL645601, AL732539, CR405681

Conserved Domains (3) summary

TIGR01628
Location:35 → 333

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:111 → 184

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12760
Location:17 → 109

RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
NM_001363195.1 → NP_001350124.1 RNA-binding protein Musashi homolog 2 isoform 4

Status: VALIDATED

Source sequence(s)

AK049637, AL645601, AL732539

Consensus CDS

CCDS88217.1

UniProtKB/TrEMBL

Q2M2Q8

Related

ENSMUSP00000103542.2, ENSMUST00000107909.8

Conserved Domains (2) summary

cd12323
Location:111 → 184

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12760
Location:17 → 109

RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
NM_001373923.1 → NP_001360852.1 RNA-binding protein Musashi homolog 2 isoform 5

Status: VALIDATED

Source sequence(s)

AL645601, AL732539, CR405681

Conserved Domains (2) summary

cd12323
Location:111 → 184

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12760
Location:17 → 109

RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
NM_054043.3 → NP_473384.1 RNA-binding protein Musashi homolog 2 isoform 1

See identical proteins and their annotated locations for NP_473384.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BK001483, BQ174763

Consensus CDS

CCDS56796.1

UniProtKB/Swiss-Prot

Q8BQ90, Q920Q6, Q920Q7

UniProtKB/TrEMBL

Q3TE41

Related

ENSMUSP00000090470.6, ENSMUST00000092794.12

Conserved Domains (3) summary

TIGR01628
Location:35 → 343

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:111 → 184

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12760
Location:17 → 109

RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

88230208..88609197 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249302.3 → XP_011247604.1 RNA-binding protein Musashi homolog 2 isoform X7

See identical proteins and their annotated locations for XP_011247604.1

Conserved Domains (3) summary

TIGR01628
Location:35 → 351

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:111 → 184

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12760
Location:17 → 109

RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
XM_036157065.1 → XP_036012958.1 RNA-binding protein Musashi homolog 2 isoform X13

Conserved Domains (2) summary

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12760
Location:17 → 104

RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
XM_006534440.4 → XP_006534503.1 RNA-binding protein Musashi homolog 2 isoform X8

Conserved Domains (3) summary

TIGR01628
Location:35 → 349

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
XM_006534435.4 → XP_006534498.1 RNA-binding protein Musashi homolog 2 isoform X3

Conserved Domains (3) summary

TIGR01628
Location:35 → 367

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
XM_036157064.1 → XP_036012957.1 RNA-binding protein Musashi homolog 2 isoform X12

Conserved Domains (2) summary

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12760
Location:17 → 104

RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
XM_006534438.4 → XP_006534501.1 RNA-binding protein Musashi homolog 2 isoform X6

Conserved Domains (3) summary

TIGR01628
Location:35 → 345

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
XM_006534439.4 → XP_006534502.1 RNA-binding protein Musashi homolog 2 isoform X5

Conserved Domains (3) summary

TIGR01628
Location:35 → 357

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
XM_006534431.4 → XP_006534494.1 RNA-binding protein Musashi homolog 2 isoform X2

Conserved Domains (3) summary

TIGR01628
Location:35 → 363

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
XM_006534432.4 → XP_006534495.1 RNA-binding protein Musashi homolog 2 isoform X1

Conserved Domains (3) summary

TIGR01628
Location:35 → 375

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
XM_006534441.5 → XP_006534504.1 RNA-binding protein Musashi homolog 2 isoform X10

Conserved Domains (3) summary

TIGR01628
Location:35 → 342

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
XM_011249305.4 → XP_011247607.1 RNA-binding protein Musashi homolog 2 isoform X18

See identical proteins and their annotated locations for XP_011247607.1

Conserved Domains (2) summary

TIGR01628
Location:39 → 266

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:26 → 99

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
XM_030246417.1 → XP_030102277.1 RNA-binding protein Musashi homolog 2 isoform X19

Conserved Domains (2) summary

TIGR01628
Location:39 → 258

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:26 → 99

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
XM_036157066.1 → XP_036012959.1 RNA-binding protein Musashi homolog 2 isoform X14

Conserved Domains (2) summary

TIGR01628
Location:71 → 298

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:58 → 131

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
XM_036157067.1 → XP_036012960.1 RNA-binding protein Musashi homolog 2 isoform X15

Conserved Domains (2) summary

TIGR01628
Location:71 → 290

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:58 → 131

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
XM_036157068.1 → XP_036012961.1 RNA-binding protein Musashi homolog 2 isoform X17

Conserved Domains (2) summary

cd12323
Location:111 → 184

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12760
Location:17 → 109

RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
XM_036157063.1 → XP_036012956.1 RNA-binding protein Musashi homolog 2 isoform X11

Conserved Domains (2) summary

cd12323
Location:111 → 184

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12760
Location:17 → 109

RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
XM_036157062.1 → XP_036012955.1 RNA-binding protein Musashi homolog 2 isoform X9

Conserved Domains (3) summary

TIGR01628
Location:35 → 337

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cl17169
Location:17 → 104

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006534434.4 → XP_006534497.1 RNA-binding protein Musashi homolog 2 isoform X4

Conserved Domains (3) summary

TIGR01628
Location:35 → 355

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
XM_011249304.4 → XP_011247606.1 RNA-binding protein Musashi homolog 2 isoform X16

Conserved Domains (2) summary

cd12323
Location:135 → 208

RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
XM_030246418.2 → XP_030102278.1 RNA-binding protein Musashi homolog 2 isoform X20

UniProtKB/TrEMBL

B1AT13

Conserved Domains (1) summary

cd12576
Location:23 → 97

RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins