Pla2g15 phospholipase A2, group XV [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g15provided by MGI
Official Full Name: phospholipase A2, group XVprovided by MGI
Primary source: MGI:MGI:2178076
See related: Ensembl:ENSMUSG00000031903 AllianceGenome:MGI:2178076
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ACS; LLPL; Lpla2; Lypla3
Summary: Enables acylglycerol O-acyltransferase activity; calcium-independent phospholipase A2 activity; and phospholipase A1 activity. Involved in ceramide metabolic process and glycerolipid metabolic process. Located in extracellular space and lysosome. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLA2G15 (phospholipase A2 group XV). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 14.2), subcutaneous fat pad adult (RPKM 13.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.1 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106876986..106891350)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (106150354..106164718)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Esterification of side-chain oxysterols by lysosomal phospholipase A2.
Title: Esterification of side-chain oxysterols by lysosomal phospholipase A2.
LPLA2 plays a role in the generation of CD1d complexes with thymic lipids required for the normal selection and maturation of iNKT cells.
Title: Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.
The secretion and uptake of lysosomal phospholipase A2 by alveolar macrophages
Title: The secretion and uptake of lysosomal phospholipase A2 by alveolar macrophages.
activity is anti-atherogenic and indicate that the regulation of this enzyme might be a novel drug target for the treatment of atherosclerosis
Title: Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice.
LPLA2 may be a major enzyme of pulmonary surfactant phospholipid degradation by alveolar macrophages
Title: Lysosomal phospholipase A2 is selectively expressed in alveolar macrophages.
identification of the catalytic triad and the role of cysteine residues in lysosomal phospholipase A2
Title: Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues.
Lpla2 has broad positional specificity for the sn-1 and sn-2 acyl groups in phosphatidylcholine and phosphatidylethanolamine
Title: Positional specificity of lysosomal phospholipase A2.
A deficiency of lysosomal phospholipase A2 results in foam cell formation, surfactant lipid accumulation, splenomegaly, and phospholipidosis in mice.
Title: Lysosomal phospholipase A2 and phospholipidosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C87498 (e-PCR)
- UniSTS:159804

RH130126 (e-PCR)
- UniSTS:213414

NoName (e-PCR)
- UniSTS:235982

NoName (e-PCR)
- UniSTS:235983

NoName (e-PCR)
- UniSTS:235990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acylglycerol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-independent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-independent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
NOT enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A1 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerophospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerophospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylethanolamine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysosomal phospholipase A and acyltransferase; phospholipase A2 group XV

Names: 1-O-acylceramide synthase; LCAT-like lysophospholipase; group XV phospholipase A2; lysophospholipase 3; lysosomal phospholipase A2

NP_001344248.1

EC 3.1.1.32

EC 3.1.1.4

NP_598553.1

EC 3.1.1.32

EC 3.1.1.4

XP_036009728.1

EC 3.1.1.32

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357319.1 → NP_001344248.1 lysosomal phospholipase A and acyltransferase isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC133195, AK028614, BM226964

Consensus CDS

CCDS90455.1

UniProtKB/TrEMBL

A0A1D5RLZ5

Related

ENSMUSP00000148565.2, ENSMUST00000212963.2

Conserved Domains (1) summary

cl21494
Location:84 → 167

Abhydrolase; alpha/beta hydrolases
NM_133792.3 → NP_598553.1 lysosomal phospholipase A and acyltransferase isoform 1 precursor

See identical proteins and their annotated locations for NP_598553.1

Status: VALIDATED

Source sequence(s)

AC133195, AK085194, BM226964

Consensus CDS

CCDS22630.1

UniProtKB/Swiss-Prot

Q3TCB1, Q3U303, Q8VEB4

Related

ENSMUSP00000034377.7, ENSMUST00000034377.8

Conserved Domains (1) summary

cl21494
Location:84 → 396

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

106876986..106891350

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153835.1 → XP_036009728.1 phospholipase A2 group XV isoform X1

Conserved Domains (1) summary

cl21494
Location:45 → 357

Abhydrolase; alpha/beta hydrolases