Meikin meiotic kinetochore factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Meikinprovided by MGI
Official Full Name: meiotic kinetochore factorprovided by MGI
Primary source: MGI:MGI:1922097
See related: Ensembl:ENSMUSG00000020332 AllianceGenome:MGI:1922097
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930404A10Rik
Summary: Acts upstream of or within meiotic chromosome segregation and meiotic sister chromatid cohesion. Located in kinetochore. Is expressed in seminiferous tubule. Orthologous to human MEIKIN (meiotic kinetochore factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 2.0) See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 32.13 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (54261478..54317616)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (54370652..54426790)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.
Title: MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.
Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition.
Title: Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition.
integrative analysis indicates that the long-awaited key regulator of meiotic kinetochore function is Meikin, which is conserved from yeasts to humans
Title: Meikin is a conserved regulator of meiosis-I-specific kinetochore function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

RH136092 (e-PCR)
- UniSTS:210087

AA943188 (e-PCR)
- UniSTS:260526

AW050338 (e-PCR)
- UniSTS:180194

NoName (e-PCR)
- UniSTS:490738

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in female meiosis chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homologous chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid cohesion involved in meiosis I	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic sister chromatid cohesion involved in meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid cohesion, centromeric	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic sister chromatid cohesion, centromeric	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: meiosis-specific kinetochore protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.