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    Dhrs11 dehydrogenase/reductase 11 [ Mus musculus (house mouse) ]

    Gene ID: 192970, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dhrs11provided by MGI
    Official Full Name
    dehydrogenase/reductase 11provided by MGI
    Primary source
    MGI:MGI:2652816
    See related
    Ensembl:ENSMUSG00000034449 AllianceGenome:MGI:2652816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. Predicted to be located in extracellular region. Is expressed in liver lobe. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in duodenum adult (RPKM 158.8), small intestine adult (RPKM 138.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhrs11 in Genome Data Viewer
    Location:
    11 C; 11 51.34 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84711547..84719880, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84820721..84829067, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700109G15 gene Neighboring gene STARR-seq mESC enhancer starr_30223 Neighboring gene STARR-seq mESC enhancer starr_30224 Neighboring gene STARR-positive B cell enhancer ABC_E3984 Neighboring gene STARR-positive B cell enhancer ABC_E375 Neighboring gene STARR-positive B cell enhancer ABC_E3985 Neighboring gene RIKEN cDNA 4930502E09 gene Neighboring gene STARR-positive B cell enhancer ABC_E3986 Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene gametogenetin binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_30226 Neighboring gene STARR-seq mESC enhancer starr_30227 Neighboring gene STARR-positive B cell enhancer ABC_E7033 Neighboring gene gametogenetin binding protein 2, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Clone Names

    • MGC18716

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3-keto sterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-keto sterol reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in estrogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 11
    Names
    17-beta-hydroxysteroid dehydrogenase
    3-beta-hydroxysteroid 3-dehydrogenase
    dehydrogenase/reductase (SDR family) member 11
    estradiol 17-beta-dehydrogenase
    short-chain dehydrogenase/reductase family 24C member 1
    NP_808232.2
    XP_030101559.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177564.5 → NP_808232.2  dehydrogenase/reductase SDR family member 11 precursor

      See identical proteins and their annotated locations for NP_808232.2

      Status: VALIDATED

      Source sequence(s)
      AL596083
      Consensus CDS
      CCDS36261.1
      UniProtKB/Swiss-Prot
      Q3U0B3, Q5SXB3, Q8R249
      Related
      ENSMUSP00000043467.8, ENSMUST00000047560.8
      Conserved Domains (2) summary
      cd05343
      Location:6 → 256
      Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs
      COG4221
      Location:6 → 259
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      84711547..84719880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245699.2 → XP_030101559.1  dehydrogenase/reductase SDR family member 11 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:1 → 177
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_003949360.2 RNA Sequence

    2. XR_001779929.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U0B3.1 GenPept UniProtKB/Swiss-Prot:Q3U0B3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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