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    Slc22a22 solute carrier family 22 (organic cation transporter), member 22 [ Mus musculus (house mouse) ]

    Gene ID: 210463, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc22a22provided by MGI
    Official Full Name
    solute carrier family 22 (organic cation transporter), member 22provided by MGI
    Primary source
    MGI:MGI:2446114
    See related
    Ensembl:ENSMUSG00000022366 AllianceGenome:MGI:2446114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    oat-pg
    Summary
    Enables prostaglandin receptor activity. Acts upstream of or within sodium-independent prostaglandin transport. Located in basolateral plasma membrane. Is expressed in metanephros; outer stripe of outer medulla; and renal proximal convoluted tubule. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward kidney adult (RPKM 8.0) See more
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    Genomic context

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    See Slc22a22 in Genome Data Viewer
    Location:
    15 D1; 15 23.88 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57107163..57341021, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (57243767..57477625, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26151 Neighboring gene STARR-seq mESC enhancer starr_38734 Neighboring gene STARR-seq mESC enhancer starr_38735 Neighboring gene predicted gene, 26178 Neighboring gene predicted gene, 49229 Neighboring gene predicted gene, 53892 Neighboring gene STARR-seq mESC enhancer starr_38737 Neighboring gene STARR-seq mESC enhancer starr_38738 Neighboring gene predicted gene, 18094 Neighboring gene STARR-seq mESC enhancer starr_38739 Neighboring gene predicted gene, 35627 Neighboring gene predicted gene, 41328

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. Shiraya K, et al. J Biol Chem, 2010 Jul 16. PMID 20448048, Free PMC Article
    2. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Jacobsson JA, et al. Genomics, 2007 Nov. PMID 17714910
    3. Characterization of chromosomal inversion of the mouse hairy ears (Eh) mutation associated with cleft palate. Katayama K, et al. Mamm Genome, 2007 Apr. PMID 17520166
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OAT-PG is proposed to be involved in the local PGE(2) clearance and metabolism for the inactivation of prostaglandin signals in the kidney cortex.
      Title: A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31374

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables prostaglandin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium-independent prostaglandin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 22 member 22
    Names
    prostaglandin-specific organic anion transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357930.1 → NP_001344859.1  solute carrier family 22 member 22

      Status: VALIDATED

      Source sequence(s)
      AC124678, AC161480
      Consensus CDS
      CCDS27481.1
      UniProtKB/Swiss-Prot
      Q8R0S9
      Related
      ENSMUSP00000022995.7, ENSMUST00000022995.13
      Conserved Domains (1) summary
      cl26863
      Location:11 → 523
      Sugar_tr; Sugar (and other) transporter

    2. NM_172378.3 → NP_759010.1  solute carrier family 22 member 22

      See identical proteins and their annotated locations for NP_759010.1

      Status: VALIDATED

      Source sequence(s)
      AC123692, AC124678, AC161480
      Consensus CDS
      CCDS27481.1
      UniProtKB/Swiss-Prot
      Q8R0S9
      Related
      ENSMUSP00000105825.2, ENSMUST00000110196.8
      Conserved Domains (1) summary
      cl26863
      Location:11 → 523
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      57107163..57341021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159295.1 → XP_036015188.1  solute carrier family 22 member 22 isoform X1

      Conserved Domains (1) summary
      cd17374
      Location:108 → 548
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    2. XM_006520697.3 → XP_006520760.1  solute carrier family 22 member 22 isoform X3

      Conserved Domains (1) summary
      cd17374
      Location:89 → 496
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    3. XM_036159296.1 → XP_036015189.1  solute carrier family 22 member 22 isoform X2

      Conserved Domains (1) summary
      cd17374
      Location:89 → 529
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    RNA

    1. XR_004938812.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0S9.1 GenPept UniProtKB/Swiss-Prot:Q8R0S9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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