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    Dcaf8 DDB1 and CUL4 associated factor 8 [ Mus musculus (house mouse) ]

    Gene ID: 98193, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dcaf8provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 8provided by MGI
    Primary source
    MGI:MGI:91860
    See related
    Ensembl:ENSMUSG00000026554 AllianceGenome:MGI:91860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H326; Wdr42a; D1Ucla4; D1Dau35e
    Summary
    Acts upstream of or within myotube cell development. Part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in several structures, including cerebral cortex; liver; lung; metanephros; and spleen. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 (DDB1 and CUL4 associated factor 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 29.6), kidney adult (RPKM 26.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcaf8 in Genome Data Viewer
    Location:
    1 H3; 1 79.54 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171975574..172023959)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172148015..172196393)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 19 Neighboring gene STARR-positive B cell enhancer ABC_E5851 Neighboring gene STARR-seq mESC enhancer starr_03051 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene proliferation and apoptosis adaptor protein 15A Neighboring gene STARR-positive B cell enhancer ABC_E9499 Neighboring gene predicted gene 17224 Neighboring gene calsequestrin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis. Zhang X, et al. Front Med, 2021 Apr. PMID 33855678
    2. ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation. Brandao R, et al. FEBS Open Bio, 2021 Jun. PMID 33730447, Free PMC Article
    3. CRL4(DCAF8) Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Li G, et al. Cell Rep, 2017 Feb 7. PMID 28178526
    4. Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation. Underhill DA, et al. Mamm Genome, 2000 Aug. PMID 10920231
    5. Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis. Welch CL, et al. Mamm Genome, 1997 Aug. PMID 9250876

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis.
      Title: DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38511

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within myotube cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 8
    Names
    WD repeat domain 42A
    WD repeat-containing protein 42A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357204.2 → NP_001344133.1  DDB1- and CUL4-associated factor 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074310
      Consensus CDS
      CCDS15509.1
      UniProtKB/Swiss-Prot
      Q8CII7, Q8CIK6, Q8N7N5
      Related
      ENSMUSP00000141732.2, ENSMUST00000192704.6
      Conserved Domains (3) summary
      TIGR00927
      Location:17 → 177
      2A1904; K+-dependent Na+/Ca+ exchanger
      sd00039
      Location:192 → 228
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:183 → 500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001421210.1 → NP_001408139.1  DDB1- and CUL4-associated factor 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074310
      UniProtKB/Swiss-Prot
      Q8CII7, Q8CIK6, Q8N7N5
      Related
      ENSMUSP00000073778.6, ENSMUST00000074144.11

    3. NM_001421211.1 → NP_001408140.1  DDB1- and CUL4-associated factor 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074310
      UniProtKB/Swiss-Prot
      Q8CII7, Q8CIK6, Q8N7N5

    4. NM_001421212.1 → NP_001408141.1  DDB1- and CUL4-associated factor 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC074310

    5. NM_001421213.1 → NP_001408142.1  DDB1- and CUL4-associated factor 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC074310

    6. NM_001421214.1 → NP_001408143.1  DDB1- and CUL4-associated factor 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC074310

    7. NM_001421215.1 → NP_001408144.1  DDB1- and CUL4-associated factor 8 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC074310

    8. NM_153555.3 → NP_705783.1  DDB1- and CUL4-associated factor 8 isoform 1

      See identical proteins and their annotated locations for NP_705783.1

      Status: VALIDATED

      Source sequence(s)
      AC074310
      Consensus CDS
      CCDS15509.1
      UniProtKB/Swiss-Prot
      Q8CII7, Q8CIK6, Q8N7N5
      Related
      ENSMUSP00000141731.2, ENSMUST00000191689.6
      Conserved Domains (3) summary
      TIGR00927
      Location:17 → 177
      2A1904; K+-dependent Na+/Ca+ exchanger
      sd00039
      Location:192 → 228
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:183 → 500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_151641.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC074310

    2. NR_185274.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC074310

    3. NR_185275.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC074310

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171975574..172023959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154566.1 → XP_036010459.1  DDB1- and CUL4-associated factor 8 isoform X2

      Related
      ENSMUSP00000141836.2, ENSMUST00000193638.6

    RNA

    1. XR_004935312.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N7N5.1 GenPept UniProtKB/Swiss-Prot:Q8N7N5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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