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    Sptssb serine palmitoyltransferase, small subunit B [ Mus musculus (house mouse) ]

    Gene ID: 66183, updated on 2-Nov-2024

    Summary

    Official Symbol
    Sptssbprovided by MGI
    Official Full Name
    serine palmitoyltransferase, small subunit Bprovided by MGI
    Primary source
    MGI:MGI:1913433
    See related
    Ensembl:ENSMUSG00000043461 AllianceGenome:MGI:1913433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADMP; Sssptb; 1110032A04Rik
    Summary
    Contributes to serine C-palmitoyltransferase activity. Acts upstream of or within ceramide biosynthetic process; endoplasmic reticulum organization; and regulation of serine C-palmitoyltransferase activity. Part of serine palmitoyltransferase complex. Is expressed in central nervous system; eye; genitourinary system; and gut. Orthologous to human SPTSSB (serine palmitoyltransferase small subunit B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 217.4) and stomach adult (RPKM 59.8) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sptssb in Genome Data Viewer
    Location:
    3 E2; 3 32.3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (69726871..69768697, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69819538..69861363, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene NMD3 ribosome export adaptor Neighboring gene predicted gene, 52662 Neighboring gene STARR-seq mESC enhancer starr_07931 Neighboring gene ribosome production factor 2 homolog pseudogene Neighboring gene predicted gene, 52608 Neighboring gene predicted gene, 35817 Neighboring gene nucleophosmin 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to serine C-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to serine C-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to serine C-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to serine C-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of serine palmitoyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of serine palmitoyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of serine palmitoyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of serine palmitoyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    serine palmitoyltransferase small subunit B
    Names
    androgen down regulated in mouse prostate
    small subunit of serine palmitoyltransferase B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164210.2NP_001157682.1  serine palmitoyltransferase small subunit B isoform a

      See identical proteins and their annotated locations for NP_001157682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AC122009, AK004017, AK009973, BC022628
      Consensus CDS
      CCDS38453.1
      UniProtKB/Swiss-Prot
      Q925E8
      Related
      ENSMUSP00000131241.2, ENSMUST00000171529.4
      Conserved Domains (1) summary
      pfam11779
      Location:760
      SPT_ssu-like; Small subunit of serine palmitoyltransferase-like
    2. NM_001286959.1NP_001273888.1  serine palmitoyltransferase small subunit B isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has a different 3' structure which results in a frameshift compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC122009
      Conserved Domains (1) summary
      pfam11779
      Location:757
      DUF3317; Protein of unknown function (DUF3317)
    3. NM_133675.3NP_598436.1  serine palmitoyltransferase small subunit B isoform a

      See identical proteins and their annotated locations for NP_598436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AC122009, AK004017, BC022628
      Consensus CDS
      CCDS38453.1
      UniProtKB/Swiss-Prot
      Q925E8
      Related
      ENSMUSP00000062794.8, ENSMUST00000051239.13
      Conserved Domains (1) summary
      pfam11779
      Location:760
      SPT_ssu-like; Small subunit of serine palmitoyltransferase-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      69726871..69768697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252751.2XP_030108611.1  serine palmitoyltransferase small subunit B isoform X1