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    Tgds TDP-glucose 4,6-dehydratase [ Mus musculus (house mouse) ]

    Gene ID: 76355, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tgdsprovided by MGI
    Official Full Name
    TDP-glucose 4,6-dehydrataseprovided by MGI
    Primary source
    MGI:MGI:1923605
    See related
    Ensembl:ENSMUSG00000022130 AllianceGenome:MGI:1923605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610017J16Rik; 2610025M23Rik
    Summary
    Predicted to enable dTDP-glucose 4,6-dehydratase activity. Predicted to be involved in nucleotide-sugar metabolic process. Is expressed in several structures, including alimentary system; cranium; eye; integumental system; and telencephalon. Human ortholog(s) of this gene implicated in Catel Manzke syndrome. Orthologous to human TGDS (TDP-glucose 4,6-dehydratase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.4), limb E14.5 (RPKM 9.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tgds in Genome Data Viewer
    Location:
    14 E4; 14 61.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (118349323..118370177, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118111911..118132765, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dopachrome tautomerase Neighboring gene STARR-positive B cell enhancer ABC_E7351 Neighboring gene nuclear encoded tRNA pheylalanine 5 (anticodon GAA) Neighboring gene predicted gene, 31633 Neighboring gene STARR-seq mESC enhancer starr_37634 Neighboring gene STARR-positive B cell enhancer ABC_E7352 Neighboring gene G protein-coupled receptor 180 Neighboring gene predicted gene 4674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice. Geister KA, et al. G3 (Bethesda), 2018 Feb 2. PMID 29208648, Free PMC Article
    2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dTDP-glucose 4,6-dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dTDP-glucose 4,6-dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in nucleotide-sugar metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    dTDP-D-glucose 4,6-dehydratase
    NP_083854.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029578.3 → NP_083854.3  dTDP-D-glucose 4,6-dehydratase

      See identical proteins and their annotated locations for NP_083854.3

      Status: VALIDATED

      Source sequence(s)
      AK165685, AK165955, BY710811, CB953719
      Consensus CDS
      CCDS27332.1
      UniProtKB/Swiss-Prot
      Q3U4A6, Q8VDR7
      UniProtKB/TrEMBL
      Q9D0D1
      Related
      ENSMUSP00000022727.9, ENSMUST00000022727.10
      Conserved Domains (2) summary
      cd05246
      Location:18 → 336
      dTDP_GD_SDR_e; dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs
      COG1088
      Location:18 → 340
      RfbB; dTDP-D-glucose 4,6-dehydratase [Cell wall/membrane/envelope biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      118349323..118370177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDR7.2 GenPept UniProtKB/Swiss-Prot:Q8VDR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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