Ovol2 ovo like zinc finger 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ovol2provided by MGI
Official Full Name: ovo like zinc finger 2provided by MGI
Primary source: MGI:MGI:1338039
See related: Ensembl:ENSMUSG00000037279 AllianceGenome:MGI:1338039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MOVO; Ovo2; M-OVO; movo2; Zfp339; M-OVO-A; M-OVO-B; 1700108N11Rik; 1810007D21Rik
Summary: Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including negative regulation of epithelial to mesenchymal transition; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including circulatory system development; positive regulation of keratinocyte differentiation; and tube morphogenesis. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; head surface ectoderm; and otocyst. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to human OVOL2 (ovo like zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 23.4), colon adult (RPKM 9.7) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 70.99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (144147095..144174000, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (144305175..144332080, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics.
Title: Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics.
Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning.
Title: Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning.
Ovol2 promoter mutations in mice and human illuminate species-specific phenotypic divergence.
Title: Ovol2 promoter mutations in mice and human illuminate species-specific phenotypic divergence.
OVOL2 sustains postnatal thymic epithelial cell identity.
Title: OVOL2 sustains postnatal thymic epithelial cell identity.
Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated beta-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes.
Title: Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes.
Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis.
Title: Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis.
The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice.
Title: The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice.
Conditional zinc finger protein mOVO (ovol2) knockout mouse model show that loss of ovol2 in embryonic germ cells does not affect fecundity in mice.
Title: Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice.
TRPV1 is a potential therapeutic target in hepatocellular carcinoma and exerts effects on cellular plasticity with modulation of Ovol2, Zeb1 and Sox10.
Title: Targeting TRPV1 on cellular plasticity regulated by Ovol 2 and Zeb 1 in hepatocellular carcinoma.
simultaneous deletion of Zeb1 encoding an EMT-promoting factor restores directional migration to Ovol2-deficient Bu-HFSCs. Taken together, our findings highlight the important function of an Ovol2-Zeb1 EMT-regulatory circuit in controlling the directional migration of epithelial stem and progenitor cells to facilitate adult skin epithelial regeneration and repair.
Title: An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

D2Dcr97 (e-PCR), detects polymorphism
- UniSTS:507656

D2Mit491 (e-PCR), detects polymorphism
- UniSTS:129409

Ovol2 (e-PCR), detects polymorphism
- UniSTS:547282

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocardium formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermis development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of stem cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by competitive promoter binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural fold formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor Ovo-like 2

Names: MOVO-B zinc finger protein; MOVO-C zinc finger protein; OVO homolog-like 2; ovo-like 2; zinc finger OVO2; zinc finger protein 339; zinc finger protein mOVO

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026924.3 → NP_081200.2 transcription factor Ovo-like 2 isoform A

See identical proteins and their annotated locations for NP_081200.2

Status: VALIDATED

Description

Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).

Source sequence(s)

AL808123

Consensus CDS

CCDS16817.1

UniProtKB/Swiss-Prot

Q505Q7, Q6F661, Q8CIV6, Q8CIV7, Q8K0D6, Q9D949

UniProtKB/TrEMBL

Q3TIV4

Related

ENSMUSP00000044026.4, ENSMUST00000037423.4

Conserved Domains (3) summary

PHA00733
Location:115 → 199

PHA00733; hypothetical protein

sd00017
Location:120 → 140

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:160 → 185

zf-H2C2_2; Zinc-finger double domain
NM_152947.3 → NP_694455.2 transcription factor Ovo-like 2 isoform B

See identical proteins and their annotated locations for NP_694455.2

Status: VALIDATED

Description

Transcript Variant: This variant (B) differs in the 5' UTR and coding sequence compared to variant A. The resulting isoform (B) has a shorter and distinct N-terminus compared to isoform A.

Source sequence(s)

AL808123

Consensus CDS

CCDS16818.1

UniProtKB/TrEMBL

Q3TIV4

Related

ENSMUSP00000099460.4, ENSMUST00000103171.10

Conserved Domains (3) summary

PHA00733
Location:82 → 166

PHA00733; hypothetical protein

sd00017
Location:87 → 107

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:127 → 152

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

144147095..144174000 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498544.4 → XP_006498607.1 transcription factor Ovo-like 2 isoform X1

Conserved Domains (3) summary

COG5189
Location:39 → 88

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:17 → 37

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:29 → 54

zf-H2C2_2; Zinc-finger double domain