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    Etfdh electron transferring flavoprotein, dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 66841, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Etfdhprovided by MGI
    Official Full Name
    electron transferring flavoprotein, dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:106100
    See related
    Ensembl:ENSMUSG00000027809 AllianceGenome:MGI:106100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610010I20Rik
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity; electron-transferring-flavoprotein dehydrogenase activity; and ubiquinone binding activity. Involved in response to oxidative stress. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in heart adult (RPKM 102.8), liver adult (RPKM 55.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Etfdh in Genome Data Viewer
    Location:
    3 E3; 3 34.91 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79511095..79536074, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79603788..79628767, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 2 Neighboring gene STARR-seq mESC enhancer starr_08000 Neighboring gene folliculin interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_08002 Neighboring gene RIKEN cDNA 4930589L23 gene Neighboring gene STARR-seq mESC enhancer starr_08006 Neighboring gene RIKEN cDNA 4930579G24 gene Neighboring gene peptidylprolyl isomerase D (cyclophilin D) Neighboring gene relaxin/insulin-like family peptide receptor 1 Neighboring gene STARR-seq mESC enhancer starr_08007 Neighboring gene VISTA enhancer mm1650

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis. Herrero Martín JC, et al. Nat Metab, 2024 Feb. PMID 38243131, Free PMC Article
    2. Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection. Beites T, et al. Nat Commun, 2021 Nov 15. PMID 34782606, Free PMC Article
    3. Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice. Chen Y, et al. Free Radic Biol Med, 2006 Nov 1. PMID 17023274
    4. Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice. Mathews CE, et al. Free Radic Biol Med, 2002 Apr 15. PMID 11937300
    5. PHOG, a candidate gene for involvement in the short stature of Turner syndrome. Ellison JW, et al. Hum Mol Genet, 1997 Aug. PMID 9259282

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis.
      Title: An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis.
    2. Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.
      Title: Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables electron-transferring-flavoprotein dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron-transferring-flavoprotein dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron-transferring-flavoprotein dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron-sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables quinone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquinone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial electron transfer flavoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
    Names
    ETF dehydrogenase
    ETF-QO
    ETF-ubiquinone oxidoreductase
    NP_080070.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025794.2 → NP_080070.2  electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080070.2

      Status: VALIDATED

      Source sequence(s)
      AK141684, AK152624, BE848473
      Consensus CDS
      CCDS17418.1
      UniProtKB/Swiss-Prot
      Q3U7K2, Q8BK82, Q921G7, Q9DCT9
      UniProtKB/TrEMBL
      Q6PF96
      Related
      ENSMUSP00000029386.8, ENSMUST00000029386.14
      Conserved Domains (3) summary
      COG0644
      Location:66 → 528
      FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
      pfam05187
      Location:511 → 614
      ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
      cl21454
      Location:67 → 261
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      79511095..79536074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921G7.1 GenPept UniProtKB/Swiss-Prot:Q921G7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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