U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mbp myelin basic protein [ Mus musculus (house mouse) ]

    Gene ID: 17196, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mbpprovided by MGI
    Official Full Name
    myelin basic proteinprovided by MGI
    Primary source
    MGI:MGI:96925
    See related
    Ensembl:ENSMUSG00000041607 AllianceGenome:MGI:96925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    jve; mld; shi; Hmbpr; golli-mbp
    Summary
    The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in cerebellum adult (RPKM 425.3), cortex adult (RPKM 253.5) and 1 other tissue See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mbp in Genome Data Viewer
    Location:
    18 E3; 18 55.84 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (82492883..82603762)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (82475091..82585637)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene galanin receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7618 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:82641329-82641438 Neighboring gene STARR-seq mESC enhancer starr_45206 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:82698694-82698847 Neighboring gene STARR-positive B cell enhancer ABC_E7619 Neighboring gene ribosomal protein L21, pseudogene 8 Neighboring gene STARR-seq mESC enhancer starr_45208 Neighboring gene predicted gene, 57823 Neighboring gene STARR-seq mESC enhancer starr_45213 Neighboring gene zinc finger protein 236 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:82886249-82886432 Neighboring gene predicted gene 10524 Neighboring gene predicted gene, 50351 Neighboring gene microRNA 5112

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells.
      Title: Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells.
    2. Involvement of Degenerating 21.5 kDa Isoform of Myelin Basic Protein in the Pathogenesis of the Relapse in Murine Relapsing-Remitting Experimental Autoimmune Encephalomyelitis and MS Autopsied Brain.
      Title: Involvement of Degenerating 21.5 kDa Isoform of Myelin Basic Protein in the Pathogenesis of the Relapse in Murine Relapsing-Remitting Experimental Autoimmune Encephalomyelitis and MS Autopsied Brain.
    3. Myelin basic protein recovery during PKU mice lifespan and the potential role of microRNAs on its regulation.
      Title: Myelin basic protein recovery during PKU mice lifespan and the potential role of microRNAs on its regulation.
    4. Developmental expression of genes involved in progesterone synthesis, metabolism and action during the post-natal cerebellar myelination.
      Title: Developmental expression of genes involved in progesterone synthesis, metabolism and action during the post-natal cerebellar myelination.
    5. Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities.
      Title: Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities.
    6. mouse MBP C8 (charge: +13) is still incorporated near cholesterol-enriched regions without SM. Thus, the highly charged C1 variant (charge: +19) needs a specific interaction with SM, whereas for C8 the incorporation at the cholesterol-rich regions is ensured due to its reduced net positive charge.
      Title: Myelin basic protein (MBP) charge variants show different sphingomyelin-mediated interactions with myelin-like lipid monolayers.
    7. In the cerebellum of the animals with antiphospholipid syndrome, it was established that the level of MBP (95-110 kDa) increased in more than 5 times (p<0.001), while the MBP (18.4 kDa) was found in very small amounts compare to the control
      Title: [MIELIN BASIC PROTEIN IN THE BRAIN TISSUE OF THE BALB/C MICE WITH EXPERIMENTAL ANTIPHOSPHOLIPID SYNDROME AND AFFECTION WITH NITRIC OXIDE SYNTHESIS MODULATORS].
    8. Myelin basic protein and the cytoplasmic domain of myelin protein zero bound and aggregated negatively charged lipid vesicles, while simultaneously folding, and both ionic strength and calcium had systematic effects on these interactions.
      Title: Ionic strength and calcium regulate membrane interactions of myelin basic protein and the cytoplasmic domain of myelin protein zero.
    9. Results support the formation of an amorphous protein phase of MBP between two membrane bilayers and provide a molecular model for major dense line formation during myelination, which is of importance when understanding myelin assembly and demyelinating conditions.
      Title: Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line.
    10. findings suggest that the acetylation and methylation of lysine on MBP are post-translational modifications associated with the neurological disability produced by EAE.
      Title: Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.
    Submit: New GeneRIF Correction See all GeneRIFs (71)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of myelin sheath IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within membrane organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within myelination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to progesterone ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to toxic substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in compact myelin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in compact myelin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in compact myelin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in internode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in internode region of axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myelin sheath HDA PubMed 
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    myelin basic protein; Golli-Mbp
    Names
    myelin A1 protein
    myelin deficient
    shiverer

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025245.1 → NP_001020416.1  Golli-Mbp isoform 2

      See identical proteins and their annotated locations for NP_001020416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains 3 exons unique to Golli-Mbp and exon 1 of the classic Mbp. It encodes the shorter of the Golli-Mbp isoforms (2).
      Source sequence(s)
      AC117825, AK039047, AK040716
      Consensus CDS
      CCDS29374.1
      UniProtKB/TrEMBL
      Q5D096
      Related
      ENSMUSP00000089393.5, ENSMUST00000091789.11
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 193
      Myelin_MBP; Myelin basic protein

    2. NM_001025251.2 → NP_001020422.1  myelin basic protein isoform 1

      See identical proteins and their annotated locations for NP_001020422.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest of the classic Mbp isoforms (1).
      Source sequence(s)
      AC119259, BF457157, BY245551, CO425201
      Consensus CDS
      CCDS29376.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000121855.3, ENSMUST00000123251.9
      Conserved Domains (1) summary
      pfam01669
      Location:14 → 194
      Myelin_MBP; Myelin basic protein

    3. NM_001025254.2 → NP_001020425.1  myelin basic protein isoform 2

      See identical proteins and their annotated locations for NP_001020425.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks exon 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (2) that is missing a 11 aa segment compared to isoform 1.
      Source sequence(s)
      BB633793, BC004704
      Consensus CDS
      CCDS37875.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000114630.3, ENSMUST00000153478.9
      Conserved Domains (1) summary
      pfam01669
      Location:14 → 183
      Myelin_MBP; Myelin basic protein

    4. NM_001025255.2 → NP_001020426.1  myelin basic protein isoform 3

      See identical proteins and their annotated locations for NP_001020426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks exon 2 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (3) that is missing a 26 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, BY245551, CK623660
      Consensus CDS
      CCDS29377.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000115082.3, ENSMUST00000142850.9
      Conserved Domains (1) summary
      pfam01669
      Location:14 → 168
      Myelin_MBP; Myelin basic protein

    5. NM_001025256.2 → NP_001020427.1  myelin basic protein isoform 4

      See identical proteins and their annotated locations for NP_001020427.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks exon 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (4) that is missing a 41 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, AK079621, BY245551
      Consensus CDS
      CCDS29378.1
      UniProtKB/TrEMBL
      A0A498WGS3, Q542T4
      Related
      ENSMUSP00000115409.3, ENSMUST00000152071.9
      Conserved Domains (1) summary
      pfam01669
      Location:14 → 148
      Myelin_MBP; Myelin basic protein

    6. NM_001025258.2 → NP_001020429.1  myelin basic protein isoform 5

      See identical proteins and their annotated locations for NP_001020429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks exons 2 and 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (5) that is missing a 26 aa and a 11 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, BY245551, M15062
      Consensus CDS
      CCDS29379.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000114230.3, ENSMUST00000132369.3
      Conserved Domains (1) summary
      pfam01669
      Location:14 → 157
      Myelin_MBP; Myelin basic protein

    7. NM_001025259.2 → NP_001020430.1  myelin basic protein isoform 6

      See identical proteins and their annotated locations for NP_001020430.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks exons 2 and 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (6) that is missing a 26 aa and a 41 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, AK005129, BY245551
      Consensus CDS
      CCDS89290.1
      UniProtKB/TrEMBL
      A0A498WGS3, Q3UGF3
      Related
      ENSMUSP00000116019.3, ENSMUST00000133193.9
      Conserved Domains (1) summary
      pfam01669
      Location:14 → 122
      Myelin_MBP; Myelin basic protein

    8. NM_010777.3 → NP_034907.1  Golli-Mbp isoform 1

      See identical proteins and their annotated locations for NP_034907.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains 3 exons unique to Golli-Mbp and exons 1, 3, 4 and 7 of the classic Mbp. It encodes the longer of the Golli-Mbp isoforms (1).
      Source sequence(s)
      AC117825, AC119259, L07507
      Consensus CDS
      CCDS29373.1
      UniProtKB/Swiss-Prot
      P04370, Q01585, Q03139, Q03176, Q61836, Q61837, Q99KE4, Q9QWP1
      UniProtKB/TrEMBL
      A0A411P8U6
      Related
      ENSMUSP00000046185.8, ENSMUST00000047865.14
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 248
      Myelin_MBP; Myelin basic protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      82492883..82603762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526452.5 → XP_006526515.1  Golli-Mbp isoform X1

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 349
      Myelin_MBP; Myelin basic protein

    2. XM_006526455.3 → XP_006526518.1  Golli-Mbp isoform X5

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 308
      Myelin_MBP; Myelin basic protein

    3. XM_006526453.4 → XP_006526516.1  Golli-Mbp isoform X2

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 327
      Myelin_MBP; Myelin basic protein

    4. XM_006526457.4 → XP_006526520.1  Golli-Mbp isoform X8

      See identical proteins and their annotated locations for XP_006526520.1

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 274
      Myelin_MBP; Myelin basic protein

    5. XM_036161011.1 → XP_036016904.1  Golli-Mbp isoform X4

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 317
      Myelin_MBP; Myelin basic protein

    6. XM_006526454.4 → XP_006526517.1  Golli-Mbp isoform X3

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 324
      Myelin_MBP; Myelin basic protein

    7. XM_030250358.2 → XP_030106218.1  Golli-Mbp isoform X9

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 282
      Myelin_MBP; Myelin basic protein

    8. XM_006526458.4 → XP_006526521.1  Golli-Mbp isoform X10

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 248
      Myelin_MBP; Myelin basic protein

    9. XM_006526456.4 → XP_006526519.1  Golli-Mbp isoform X6

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 301
      Myelin_MBP; Myelin basic protein

    10. XM_036161013.1 → XP_036016906.1  Golli-Mbp isoform X7

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 291
      Myelin_MBP; Myelin basic protein

    11. XM_036161014.1 → XP_036016907.1  myelin basic protein isoform X11

      Conserved Domains (1) summary
      pfam01669
      Location:14 → 217
      Myelin_MBP; Myelin basic protein

    12. XM_036161010.1 → XP_036016903.1  Golli-Mbp isoform X3

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 324
      Myelin_MBP; Myelin basic protein

    13. XM_030250356.1 → XP_030106216.1  Golli-Mbp isoform X1

      UniProtKB/TrEMBL
      A0A411P8U6
      Conserved Domains (1) summary
      pfam01669
      Location:147 → 349
      Myelin_MBP; Myelin basic protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04370.2 GenPept UniProtKB/Swiss-Prot:P04370

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools