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    TSSK1B testis specific serine kinase 1B [ Homo sapiens (human) ]

    Gene ID: 83942, updated on 14-Nov-2024

    Summary

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    Official Symbol
    TSSK1Bprovided by HGNC
    Official Full Name
    testis specific serine kinase 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:14968
    See related
    Ensembl:ENSG00000212122 MIM:610709; AllianceGenome:HGNC:14968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSK1; TSSK1; FKSG81; SPOGA4; STK22D
    Summary
    TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]
    Orthologs
    mouse all
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    Genomic context

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    See TSSK1B in Genome Data Viewer
    Location:
    5q22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (113432553..113434989, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (113945250..113947686, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112768250..112770686, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:112312161-112312920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:112317139-112317674 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:112369970-112370528 Neighboring gene decapping mRNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:112379403-112379941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:112404856-112405632 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:112405633-112406407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:112409037-112409538 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:112416605-112417526 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:112417522-112418721 Neighboring gene MCC regulator of WNT signaling pathway Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:112454694-112455201 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:112502443-112503642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:112538908-112539449 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:112571092-112572066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:112580307-112581082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16242 Neighboring gene uncharacterized LOC124901045 Neighboring gene MPRA-validated peak5422 silencer Neighboring gene uncharacterized LOC107986366 Neighboring gene Sharpr-MPRA regulatory region 13961 Neighboring gene RNA, U4atac small nuclear 13, pseudogene Neighboring gene uncharacterized LOC124901046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22921 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:112849193-112849694

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of testis‑specific serine kinase 1B in undiagnosed male infertility. Kadiyska T, et al. Mol Med Rep, 2022 Jun. PMID 35485285, Free PMC Article
    2. Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays. Zhang L, et al. J Med Chem, 2009 Jul 23. PMID 19530700
    3. Evolution of testis-specific kinases TSSK1B and TSSK2 in primates. Shang P, et al. Andrology, 2013 Jan. PMID 23258646
    4. Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase. Bashkirov VI, et al. Mol Cell Biol, 2003 Feb. PMID 12556502, Free PMC Article
    5. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. Hao Z, et al. Mol Hum Reprod, 2004 Jun. PMID 15044604

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of testisspecific serine kinase 1B in undiagnosed male infertility.
      Title: Role of testis‑specific serine kinase 1B in undiagnosed male infertility.
    2. Report evolution of testis-specific kinases TSSK1B and TSSK2 in primates.
      Title: Evolution of testis-specific kinases TSSK1B and TSSK2 in primates.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific serine/threonine-protein kinase 1
    Names
    TSK-1
    TSSK-1
    serine/threonine kinase 22D (spermiogenesis associated)
    serine/threonine kinase FKSG81
    serine/threonine-protein kinase 22A
    spermiogenesis associated 4
    testis tissue sperm-binding protein Li 55e
    testis-specific kinase 1
    testis-specific serine kinase 1
    NP_114417.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032028.4 → NP_114417.1  testis-specific serine/threonine-protein kinase 1

      See identical proteins and their annotated locations for NP_114417.1

      Status: VALIDATED

      Source sequence(s)
      AC010431, AK122904, BC022515, DB025324, DB527624
      Consensus CDS
      CCDS4112.1
      UniProtKB/Swiss-Prot
      B2R8D9, Q9BXA7
      UniProtKB/TrEMBL
      A0ZT98
      Related
      ENSP00000375081.3, ENST00000390666.4
      Conserved Domains (1) summary
      cd14165
      Location:10 → 272
      STKc_TSSK1_2-like; Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      113432553..113434989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      113945250..113947686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BXA7.1 GenPept UniProtKB/Swiss-Prot:Q9BXA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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