DUSP15 dual specificity phosphatase 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DUSP15provided by HGNC
Official Full Name: dual specificity phosphatase 15provided by HGNC
Primary source: HGNC:HGNC:16236
See related: Ensembl:ENSG00000149599 MIM:616776; AllianceGenome:HGNC:16236
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VHY; C20orf57
Summary: The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression: Biased expression in testis (RPKM 10.5), kidney (RPKM 3.2) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (31845593..31870664, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (33570201..33595274, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (30435440..30458467, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein.
Title: Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein.
Association between Genetic Variants in DUSP15, CNTNAP2, and PCDHA Genes and Risk of Childhood Autism Spectrum Disorder.
Title: Association between Genetic Variants in DUSP15, CNTNAP2, and PCDHA Genes and Risk of Childhood Autism Spectrum Disorder.
The results showed that dual specificity phosphatase 15 (DUSP15) rs3746599 was significantly associated with autism under allelic, additive and dominant models,The findings initially suggest that DUSP15 might be a susceptibility gene for autism in Chinese Han population.
Title: Association of oligodendrocytes differentiation regulator gene DUSP15 with autism.
Dusp15/VHY is a key regulator of oligodendrocyte differentiation, and PDGFR-beta and SNX6 are novel and specific Dusp15 substrates.
Title: Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach.
VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases
Title: VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.
crystal structure of catalytic domain
Title: Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine/serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: dual specificity protein phosphatase 15

Names: VH1-related member Y; dual specificity phosphatase-like 15; vaccinia virus VH1-related dual-specific protein phosphatase Y

NP_001012662.1

EC 3.1.3.16

EC 3.1.3.48

NP_001307407.1

EC 3.1.3.16

EC 3.1.3.48

NP_001307408.1

EC 3.1.3.16

EC 3.1.3.48

NP_542178.2

EC 3.1.3.16

EC 3.1.3.48

NP_817130.1

EC 3.1.3.16

EC 3.1.3.48

XP_016883143.1

EC 3.1.3.16

EC 3.1.3.48

XP_016883144.1

EC 3.1.3.16

EC 3.1.3.48

XP_016883145.1

EC 3.1.3.16

EC 3.1.3.48

XP_016883146.1

EC 3.1.3.16

EC 3.1.3.48

XP_016883147.1

EC 3.1.3.16

EC 3.1.3.48

XP_016883148.1

EC 3.1.3.16

EC 3.1.3.48

XP_016883149.1

EC 3.1.3.16

EC 3.1.3.48

XP_016883150.1

EC 3.1.3.16

EC 3.1.3.48

XP_016883151.1

EC 3.1.3.16

EC 3.1.3.48

XP_047295846.1

EC 3.1.3.16

EC 3.1.3.48

XP_047295847.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178944.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178945.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178946.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178947.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178948.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178949.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178950.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178951.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178952.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178953.1

EC 3.1.3.16

EC 3.1.3.48

XP_054178954.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012644.3 → NP_001012662.1 dual specificity protein phosphatase 15 isoform b

See identical proteins and their annotated locations for NP_001012662.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to isoform a. Variants 2 and 3 both encode isoform b, which has a shorter N-terminus than isoform a.

Source sequence(s)

AI051640, AK091960, AL732169, BC056911, BF377396, DN996690

Consensus CDS

CCDS42862.1

UniProtKB/Swiss-Prot

Q9H1R2

Related

ENSP00000381157.1, ENST00000398083.5

Conserved Domains (1) summary

cl21483
Location:1 → 35

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001320478.1 → NP_001307407.1 dual specificity protein phosphatase 15 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (c) has a distinct, shorter N-terminus than isoform a.

Source sequence(s)

AI051640, AK091960, AK097430, BM554314

Consensus CDS

CCDS82607.1

UniProtKB/Swiss-Prot

Q9H1R2

Related

ENSP00000365133.4, ENST00000375966.8

Conserved Domains (1) summary

cd00127
Location:1 → 135

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
NM_001320479.1 → NP_001307408.1 dual specificity protein phosphatase 15 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains multiple differences at both the 5' and 3' ends, compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (d) has distinct N- and C-termini and is longer than isoform a.

Source sequence(s)

AK000652, AK097430

Consensus CDS

CCDS82606.1

UniProtKB/Swiss-Prot

A6NH79, A8MVC8, Q5QP62, Q5QP63, Q5QP65, Q6PGN7, Q8N826, Q9BX24, Q9H1R2

Related

ENSP00000278979.3, ENST00000278979.7

Conserved Domains (1) summary

cl28904
Location:5 → 142

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_080611.5 → NP_542178.2 dual specificity protein phosphatase 15 isoform a

See identical proteins and their annotated locations for NP_542178.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AL160175

Consensus CDS

CCDS13193.1

UniProtKB/Swiss-Prot

Q9H1R2

Related

ENSP00000341658.5, ENST00000339738.10

Conserved Domains (1) summary

cd00127
Location:4 → 138

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
NM_177991.3 → NP_817130.1 dual specificity protein phosphatase 15 isoform b

See identical proteins and their annotated locations for NP_817130.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to isoform a. Variants 2 and 3 both encode isoform b, which has a shorter N-terminus than isoform a.

Source sequence(s)

AI051640, AK091960, BI517878, DN996690

Consensus CDS

CCDS42862.1

UniProtKB/Swiss-Prot

Q9H1R2

Related

ENSP00000381158.2, ENST00000398084.6

Conserved Domains (1) summary

cl21483
Location:1 → 35

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

31845593..31870664 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017027656.2 → XP_016883145.1 dual specificity protein phosphatase 15 isoform X3
XM_017027655.2 → XP_016883144.1 dual specificity protein phosphatase 15 isoform X2
XM_017027657.2 → XP_016883146.1 dual specificity protein phosphatase 15 isoform X4
XM_017027654.2 → XP_016883143.1 dual specificity protein phosphatase 15 isoform X1
XM_017027660.2 → XP_016883149.1 dual specificity protein phosphatase 15 isoform X5
XM_017027658.2 → XP_016883147.1 dual specificity protein phosphatase 15 isoform X5
XM_017027659.2 → XP_016883148.1 dual specificity protein phosphatase 15 isoform X5
XM_017027662.2 → XP_016883151.1 dual specificity protein phosphatase 15 isoform X5
XM_017027661.2 → XP_016883150.1 dual specificity protein phosphatase 15 isoform X5
XM_047439890.1 → XP_047295846.1 dual specificity protein phosphatase 15 isoform X6
XM_047439891.1 → XP_047295847.1 dual specificity protein phosphatase 15 isoform X7

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

33570201..33595274 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054322971.1 → XP_054178946.1 dual specificity protein phosphatase 15 isoform X3
XM_054322970.1 → XP_054178945.1 dual specificity protein phosphatase 15 isoform X2
XM_054322972.1 → XP_054178947.1 dual specificity protein phosphatase 15 isoform X4
XM_054322969.1 → XP_054178944.1 dual specificity protein phosphatase 15 isoform X1
XM_054322974.1 → XP_054178949.1 dual specificity protein phosphatase 15 isoform X5
XM_054322973.1 → XP_054178948.1 dual specificity protein phosphatase 15 isoform X5
XM_054322975.1 → XP_054178950.1 dual specificity protein phosphatase 15 isoform X5
XM_054322977.1 → XP_054178952.1 dual specificity protein phosphatase 15 isoform X5
XM_054322976.1 → XP_054178951.1 dual specificity protein phosphatase 15 isoform X5
XM_054322978.1 → XP_054178953.1 dual specificity protein phosphatase 15 isoform X6
XM_054322979.1 → XP_054178954.1 dual specificity protein phosphatase 15 isoform X7