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    DBF4B DBF4B-CDC7 kinase regulatory subunit [ Homo sapiens (human) ]

    Gene ID: 80174, updated on 2-Nov-2024

    Summary

    Official Symbol
    DBF4Bprovided by HGNC
    Official Full Name
    DBF4B-CDC7 kinase regulatory subunitprovided by HGNC
    Primary source
    HGNC:HGNC:17883
    See related
    Ensembl:ENSG00000161692 MIM:611661; AllianceGenome:HGNC:17883
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRF1; ASKL1; CHIFB; ZDBF1B
    Summary
    This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
    Expression
    Broad expression in testis (RPKM 5.4), brain (RPKM 1.1) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DBF4B in Genome Data Viewer
    Location:
    17q21.31; 17q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (44708665..44752264)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45532923..45606211)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42786033..42829632)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:42766877-42767466 Neighboring gene uncharacterized LOC124904010 Neighboring gene coiled-coil domain containing 43 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:42785839-42786353 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:42786354-42786867 Neighboring gene RNA, 7SL, cytoplasmic 819, pseudogene Neighboring gene ribosomal protein L6 pseudogene 26 Neighboring gene uncharacterized LOC107985044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42830428-42830928 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42835997-42836548 Neighboring gene ADAM metallopeptidase domain 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42853416-42853916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42856011-42856852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8601 Neighboring gene gap junction protein gamma 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8602 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:42907313-42908286 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42908287-42909260

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13087, MGC15009

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Dbf4-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein DBF4 homolog B
    Names
    ASK-like protein 1
    DBF4 homolog B
    DBF4 zinc finger B
    Dbf4-related factor 1
    activator of S-phase kinase-like protein 1
    chiffon homolog B
    zinc finger, DBF-type containing 1B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025104.4NP_079380.2  protein DBF4 homolog B isoform 2

      See identical proteins and their annotated locations for NP_079380.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AW290902, BC016158
      Consensus CDS
      CCDS45706.2
      UniProtKB/Swiss-Prot
      Q8NFT6
      Related
      ENSP00000377178.2, ENST00000393547.6
      Conserved Domains (1) summary
      pfam07535
      Location:299340
      zf-DBF; DBF zinc finger
    2. NM_145663.3NP_663696.1  protein DBF4 homolog B isoform 1

      See identical proteins and their annotated locations for NP_663696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF448801, AW290902, BC016158
      Consensus CDS
      CCDS11485.1
      UniProtKB/Swiss-Prot
      D3DX56, Q8NFT6, Q8TEX0, Q96B19, Q9H912
      Related
      ENSP00000323663.3, ENST00000315005.8
      Conserved Domains (2) summary
      COG5067
      Location:18340
      DBF4; Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]
      pfam07535
      Location:299340
      zf-DBF; DBF zinc finger

    RNA

    1. NR_036623.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005180, BC016158, BC033660, BM476186, DA475446
      Related
      ENST00000526924.5
    2. NR_148206.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple alternate internal exons in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005180, AC091152, AW290902
    3. NR_148207.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks multiple alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005180, AC091152, AW290902

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      44708665..44752264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436820.1XP_047292776.1  protein DBF4 homolog B isoform X15

    2. XM_017025150.3XP_016880639.1  protein DBF4 homolog B isoform X12

    3. XM_047436822.1XP_047292778.1  protein DBF4 homolog B isoform X18

    4. XM_047436817.1XP_047292773.1  protein DBF4 homolog B isoform X10

    5. XM_006722098.4XP_006722161.1  protein DBF4 homolog B isoform X2

      Conserved Domains (2) summary
      COG5067
      Location:18340
      DBF4; Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]
      pfam07535
      Location:299340
      zf-DBF; DBF zinc finger
    6. XM_047436814.1XP_047292770.1  protein DBF4 homolog B isoform X7

    7. XM_024450953.2XP_024306721.1  protein DBF4 homolog B isoform X4

      Conserved Domains (1) summary
      pfam07535
      Location:278319
      zf-DBF; DBF zinc finger
    8. XM_047436815.1XP_047292771.1  protein DBF4 homolog B isoform X8

    9. XM_047436810.1XP_047292766.1  protein DBF4 homolog B isoform X3

    10. XM_047436812.1XP_047292768.1  protein DBF4 homolog B isoform X5

    11. XM_047436811.1XP_047292767.1  protein DBF4 homolog B isoform X5

    12. XM_047436818.1XP_047292774.1  protein DBF4 homolog B isoform X11

    13. XM_047436821.1XP_047292777.1  protein DBF4 homolog B isoform X17

    14. XM_047436816.1XP_047292772.1  protein DBF4 homolog B isoform X9

    15. XM_047436819.1XP_047292775.1  protein DBF4 homolog B isoform X14

    16. XM_047436813.1XP_047292769.1  protein DBF4 homolog B isoform X6

    17. XM_047436809.1XP_047292765.1  protein DBF4 homolog B isoform X1

    18. XM_011525281.3XP_011523583.1  protein DBF4 homolog B isoform X13

      See identical proteins and their annotated locations for XP_011523583.1

      UniProtKB/Swiss-Prot
      Q8NFT6
      Conserved Domains (1) summary
      pfam07535
      Location:113154
      zf-DBF; DBF zinc finger
    19. XM_017025155.2XP_016880644.1  protein DBF4 homolog B isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      45532923..45606211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317351.1XP_054173326.1  protein DBF4 homolog B isoform X2

    2. XM_054317365.1XP_054173340.1  protein DBF4 homolog B isoform X15

    3. XM_054317362.1XP_054173337.1  protein DBF4 homolog B isoform X12

    4. XM_054317368.1XP_054173343.1  protein DBF4 homolog B isoform X18

    5. XM_054317360.1XP_054173335.1  protein DBF4 homolog B isoform X10

    6. XM_054317357.1XP_054173332.1  protein DBF4 homolog B isoform X7

    7. XM_054317353.1XP_054173328.1  protein DBF4 homolog B isoform X4

    8. XM_054317358.1XP_054173333.1  protein DBF4 homolog B isoform X8

    9. XM_054317352.1XP_054173327.1  protein DBF4 homolog B isoform X3

    10. XM_054317355.1XP_054173330.1  protein DBF4 homolog B isoform X5

    11. XM_054317354.1XP_054173329.1  protein DBF4 homolog B isoform X5

    12. XM_054317361.1XP_054173336.1  protein DBF4 homolog B isoform X11

    13. XM_054317367.1XP_054173342.1  protein DBF4 homolog B isoform X17

    14. XM_054317359.1XP_054173334.1  protein DBF4 homolog B isoform X9

    15. XM_054317364.1XP_054173339.1  protein DBF4 homolog B isoform X14

    16. XM_054317356.1XP_054173331.1  protein DBF4 homolog B isoform X6

    17. XM_054317350.1XP_054173325.1  protein DBF4 homolog B isoform X1

    18. XM_054317363.1XP_054173338.1  protein DBF4 homolog B isoform X13

    19. XM_054317366.1XP_054173341.1  protein DBF4 homolog B isoform X16