Bcl2l14 BCL2 like 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcl2l14provided by MGI
Official Full Name: BCL2 like 14provided by MGI
Primary source: MGI:MGI:1914063
See related: Ensembl:ENSMUSG00000030200 AllianceGenome:MGI:1914063
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bclg; Bcl-G; 4930452K23Rik; 4933405K19Rik; 9030625M01Rik
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in apoptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be located in cytosol. Is expressed in early embryo; genitourinary system; gut; and submandibular gland primordium. Orthologous to human BCL2L14 (BCL2 like 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 24.0), duodenum adult (RPKM 4.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 65.22 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (134373292..134415687)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (134396329..134438724)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD3/CD28-inducible MNSFbeta-Bcl-G complex may be involved in the regulation of T cell function and survival.
Title: Ubiquitin-like protein MNSFβ negatively regulates T cell function and survival.
The Bcl-G interacts specifically with proteins of the transport particle protein complex.
Title: Bcl-2 family member Bcl-G is not a proapoptotic protein.
Bcl-G is expressed highly in mature spermatids in the testis, CD8(+) conventional dendritic cells (DCs) in hematopoietic tissues and diverse epithelial cell types, including those lining the gastrointestinal and respiratory tracts.
Title: Detection of Bcl-2 family member Bcl-G in mouse tissues using new monoclonal antibodies.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apoptosis facilitator Bcl-2-like protein 14

Names: BCL2-like 14 (apoptosis facilitator); apoptosis regulator BCL-G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355686.1 → NP_001342615.1 apoptosis facilitator Bcl-2-like protein 14

Status: VALIDATED

Source sequence(s)

AC155838, AK018579

Consensus CDS

CCDS20636.1

UniProtKB/Swiss-Prot

Q3TVA7, Q8R141, Q9CPT0, Q9D3W3

Related

ENSMUSP00000107591.2, ENSMUST00000111960.2

Conserved Domains (1) summary

cl02575
Location:293 → 316

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
NM_025778.3 → NP_080054.1 apoptosis facilitator Bcl-2-like protein 14

See identical proteins and their annotated locations for NP_080054.1

Status: VALIDATED

Source sequence(s)

AC155838

Consensus CDS

CCDS20636.1

UniProtKB/Swiss-Prot

Q3TVA7, Q8R141, Q9CPT0, Q9D3W3

Related

ENSMUSP00000032321.5, ENSMUST00000032321.11

Conserved Domains (1) summary

cl02575
Location:293 → 316

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...