Morc1 microrchidia 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Morc1provided by MGI
Official Full Name: microrchidia 1provided by MGI
Primary source: MGI:MGI:1316740
See related: Ensembl:ENSMUSG00000022652 AllianceGenome:MGI:1316740
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Morc
Summary: Predicted to enable zinc ion binding activity. Involved in negative regulation of gene expression and spermatogenesis. Acts upstream of or within behavioral fear response and regulation of gene expression. Is active in male germ cell nucleus. Is expressed in esophagus; head mesenchyme; musculoskeletal system; sensory organ; and testis. Used to study melancholic depression. Orthologous to human MORC1 (MORC family CW-type zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 30.75 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (48251600..48451268)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (48431237..48630905)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes.
Title: Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes.
Morc1-/- mice display increased depressive-like behavior; a promising novel mouse model for depression.
Title: Morc1 knockout evokes a depression-like phenotype in mice.
MORC1 represses transposable elements in the mouse male germline.
Title: MORC1 represses transposable elements in the mouse male germline.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Transgenic (1) 1 citation

General gene information

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Markers

AU022867 (e-PCR)
- UniSTS:209220

NoName (e-PCR)
- UniSTS:224389

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epigenetic programing of male pronucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
acts_upstream_of retrotransposition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retrotransposon silencing by heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MORC family CW-type zinc finger protein 1

Names: protein microrchidia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010816.1 → NP_034946.1 MORC family CW-type zinc finger protein 1

See identical proteins and their annotated locations for NP_034946.1

Status: PROVISIONAL

Source sequence(s)

AF084945

Consensus CDS

CCDS37351.1

UniProtKB/Swiss-Prot

Q9WVL5

Related

ENSMUSP00000023330.7, ENSMUST00000023330.8

Conserved Domains (2) summary

pfam07496
Location:481 → 528

zf-CW; CW-type Zinc Finger

cl00075
Location:27 → 159

HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins