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    Pdpr pyruvate dehydrogenase phosphatase regulatory subunit [ Mus musculus (house mouse) ]

    Gene ID: 319518, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pdprprovided by MGI
    Official Full Name
    pyruvate dehydrogenase phosphatase regulatory subunitprovided by MGI
    Primary source
    MGI:MGI:2442188
    See related
    Ensembl:ENSMUSG00000033624 AllianceGenome:MGI:2442188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1990; 4930402E16Rik
    Summary
    Located in mitochondrion. Is expressed in cerebral cortex; heart; and liver. Orthologous to human PDPR (pyruvate dehydrogenase phosphatase regulatory subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 14.4), kidney adult (RPKM 8.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pdpr in Genome Data Viewer
    Location:
    8 E1; 8 57.95 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111821232..111866402)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111094609..111139781)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC) Neighboring gene C-type lectin domain family 18, member A Neighboring gene RIKEN cDNA 9430091E24 gene Neighboring gene golgi apparatus protein 1 Neighboring gene STARR-seq mESC enhancer starr_22692 Neighboring gene STARR-positive B cell enhancer ABC_E708 Neighboring gene predicted gene, 53455 Neighboring gene ring finger and WD repeat domain 3 Neighboring gene STARR-seq mESC enhancer starr_22693

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Bowman CE, et al. Mol Cell Biol, 2016 Aug 1. PMID 27215380, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
    NP_938050.1
    XP_006531147.1
    XP_030099464.1
    XP_036009980.1
    XP_036009981.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198308.1 → NP_938050.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_938050.1

      Status: PROVISIONAL

      Source sequence(s)
      AY223867
      Consensus CDS
      CCDS22670.1
      UniProtKB/Swiss-Prot
      Q6ZPF5, Q7TSQ8
      Related
      ENSMUSP00000046639.4, ENSMUST00000039333.10
      Conserved Domains (2) summary
      COG0404
      Location:452 → 867
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:38 → 425
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111821232..111866402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531084.5 → XP_006531147.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006531147.1

      UniProtKB/Swiss-Prot
      Q6ZPF5, Q7TSQ8
      Conserved Domains (2) summary
      COG0404
      Location:452 → 867
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:38 → 425
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    2. XM_036154087.1 → XP_036009980.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X2

      UniProtKB/TrEMBL
      D6RD07
      Related
      ENSMUSP00000121325.2, ENSMUST00000144377.2
      Conserved Domains (3) summary
      pfam01266
      Location:44 → 384
      DAO; FAD dependent oxidoreductase
      pfam01571
      Location:462 → 688
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam16350
      Location:405 → 459
      FAO_M; FAD dependent oxidoreductase central domain

    3. XM_036154088.1 → XP_036009981.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X3

      Conserved Domains (2) summary
      COG0404
      Location:51 → 466
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam16350
      Location:4 → 58
      FAO_M; FAD dependent oxidoreductase central domain

    4. XM_030243604.2 → XP_030099464.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X3

      Conserved Domains (2) summary
      COG0404
      Location:51 → 466
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam16350
      Location:4 → 58
      FAO_M; FAD dependent oxidoreductase central domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSQ8.1 GenPept UniProtKB/Swiss-Prot:Q7TSQ8

    Gene LinkOut

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