Gas2 growth arrest specific 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gas2provided by MGI
Official Full Name: growth arrest specific 2provided by MGI
Primary source: MGI:MGI:95657
See related: Ensembl:ENSMUSG00000030498 AllianceGenome:MGI:95657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gas-2
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including ovarian follicle development; ovulation; and regulation of Notch signaling pathway. Predicted to be located in cytoplasm; membrane; and stress fiber. Predicted to be active in actin filament. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and limb. Used to study sensorineural hearing loss. Orthologous to human GAS2 (growth arrest specific 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 19.6), kidney adult (RPKM 14.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B4; 7 32.87 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (51511560..51644753)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (51861791..51995005)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.
Title: Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.
GAS2 is a critical and novel regulator of tissue remodeling in the ovary during oocyte cyst breakdown and folliculogenesis
Title: Growth Arrest Specific 2 (GAS2) is a Critical Mediator of Germ Cell Cyst Breakdown and Folliculogenesis in Mice.
these findings suggest that downregulated miR3425p is involved in regulating cell proliferation and cell cycles in Zmpste24/ MEFs by suppressing GAS2 in vitro.
Title: miR‑342‑5p promotes Zmpste24‑deficient mouse embryonic fibroblasts proliferation by suppressing GAS2.
Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin
Title: The calpain system is involved in the constitutive regulation of beta-catenin signaling functions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M21828 (e-PCR)
- UniSTS:124931

Gas2 (e-PCR), detects polymorphism
- UniSTS:472854

Gas2 (e-PCR), detects polymorphism
- UniSTS:496736

M21828 (e-PCR)
- UniSTS:159648

D7Mit18 (e-PCR), detects polymorphism
- UniSTS:131070

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antral ovarian follicle growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within initiation of primordial ovarian follicle growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth arrest-specific protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330607.2 → NP_001317536.1 growth arrest-specific protein 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, and 4-11 all encode the same isoform (1).

Source sequence(s)

AC113312, AC122017, AC158345

Consensus CDS

CCDS21310.1

UniProtKB/Swiss-Prot

P11862

Related

ENSMUSP00000053514.7, ENSMUST00000051912.13

Conserved Domains (2) summary

smart00243
Location:201 → 274

GAS2; Growth-Arrest-Specific Protein 2 Domain

cd00014
Location:36 → 158

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
NM_001330608.2 → NP_001317537.1 growth arrest-specific protein 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the 5' UTR, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC113312, AC122017, AC158345

UniProtKB/TrEMBL

Q9D699

Conserved Domains (2) summary

smart00243
Location:143 → 216

GAS2; Growth-Arrest-Specific Protein 2 Domain

cl00030
Location:1 → 100

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
NM_001412458.1 → NP_001399387.1 growth arrest-specific protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345

UniProtKB/Swiss-Prot

P11862
NM_001412459.1 → NP_001399388.1 growth arrest-specific protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345

UniProtKB/Swiss-Prot

P11862
NM_001412460.1 → NP_001399389.1 growth arrest-specific protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345

UniProtKB/Swiss-Prot

P11862
NM_001412461.1 → NP_001399390.1 growth arrest-specific protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345

UniProtKB/Swiss-Prot

P11862
NM_001412462.1 → NP_001399391.1 growth arrest-specific protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345

UniProtKB/Swiss-Prot

P11862
NM_001412463.1 → NP_001399392.1 growth arrest-specific protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345

UniProtKB/Swiss-Prot

P11862
NM_001412464.1 → NP_001399393.1 growth arrest-specific protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345

UniProtKB/Swiss-Prot

P11862

Related

ENSMUSP00000146537.2, ENSMUST00000208711.2
NM_001412465.1 → NP_001399394.1 growth arrest-specific protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345

UniProtKB/Swiss-Prot

P11862
NM_001412466.1 → NP_001399395.1 growth arrest-specific protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345
NM_001412467.1 → NP_001399396.1 growth arrest-specific protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345
NM_001412468.1 → NP_001399397.1 growth arrest-specific protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345
NM_001412469.1 → NP_001399398.1 growth arrest-specific protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345
NM_008087.4 → NP_032113.1 growth arrest-specific protein 2 isoform 1

See identical proteins and their annotated locations for NP_032113.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 4-11 all encode the same isoform (1).

Source sequence(s)

AC113312, AC122017, AC158345

Consensus CDS

CCDS21310.1

UniProtKB/Swiss-Prot

P11862

Related

ENSMUSP00000103217.3, ENSMUST00000107591.9

Conserved Domains (2) summary

smart00243
Location:201 → 274

GAS2; Growth-Arrest-Specific Protein 2 Domain

cd00014
Location:36 → 158

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

RNA

NR_178198.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345
NR_178199.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345
NR_178200.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345
NR_178201.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345
NR_178202.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC113312, AC122017, AC158345

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

51511560..51644753

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242137.2 → XP_030097997.1 growth arrest-specific protein 2 isoform X2

UniProtKB/Swiss-Prot

P11862

Conserved Domains (2) summary

smart00243
Location:201 → 274

GAS2; Growth-Arrest-Specific Protein 2 Domain

cd00014
Location:36 → 158

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
XM_006540619.5 → XP_006540682.1 growth arrest-specific protein 2 isoform X1

See identical proteins and their annotated locations for XP_006540682.1

Conserved Domains (2) summary

smart00243
Location:228 → 301

GAS2; Growth-Arrest-Specific Protein 2 Domain

cl00030
Location:30 → 191

CH_SF; calponin homology (CH) domain superfamily
XM_036152682.1 → XP_036008575.1 growth arrest-specific protein 2 isoform X3

Conserved Domains (2) summary

cl00030
Location:30 → 191

CH_SF; calponin homology (CH) domain superfamily

cl02524
Location:230 → 270

GAS2; Growth-Arrest-Specific Protein 2 Domain
XM_030242140.2 → XP_030098000.1 growth arrest-specific protein 2 isoform X2

UniProtKB/Swiss-Prot

P11862

Conserved Domains (2) summary

smart00243
Location:201 → 274

GAS2; Growth-Arrest-Specific Protein 2 Domain

cd00014
Location:36 → 158

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
XM_036152681.1 → XP_036008574.1 growth arrest-specific protein 2 isoform X1

Conserved Domains (2) summary

smart00243
Location:228 → 301

GAS2; Growth-Arrest-Specific Protein 2 Domain

cl00030
Location:30 → 191

CH_SF; calponin homology (CH) domain superfamily
XM_006540623.4 → XP_006540686.1 growth arrest-specific protein 2 isoform X1

See identical proteins and their annotated locations for XP_006540686.1

Conserved Domains (2) summary

smart00243
Location:228 → 301

GAS2; Growth-Arrest-Specific Protein 2 Domain

cl00030
Location:30 → 191

CH_SF; calponin homology (CH) domain superfamily
XM_006540618.3 → XP_006540681.1 growth arrest-specific protein 2 isoform X1

See identical proteins and their annotated locations for XP_006540681.1

Conserved Domains (2) summary

smart00243
Location:228 → 301

GAS2; Growth-Arrest-Specific Protein 2 Domain

cl00030
Location:30 → 191

CH_SF; calponin homology (CH) domain superfamily
XM_006540622.3 → XP_006540685.1 growth arrest-specific protein 2 isoform X1

See identical proteins and their annotated locations for XP_006540685.1

Conserved Domains (2) summary

smart00243
Location:228 → 301

GAS2; Growth-Arrest-Specific Protein 2 Domain

cl00030
Location:30 → 191

CH_SF; calponin homology (CH) domain superfamily
XM_006540621.5 → XP_006540684.1 growth arrest-specific protein 2 isoform X1

See identical proteins and their annotated locations for XP_006540684.1

Conserved Domains (2) summary

smart00243
Location:228 → 301

GAS2; Growth-Arrest-Specific Protein 2 Domain

cl00030
Location:30 → 191

CH_SF; calponin homology (CH) domain superfamily