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    Magt1 magnesium transporter 1 [ Mus musculus (house mouse) ]

    Gene ID: 67075, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Magt1provided by MGI
    Official Full Name
    magnesium transporter 1provided by MGI
    Primary source
    MGI:MGI:1914325
    See related
    Ensembl:ENSMUSG00000031232 AllianceGenome:MGI:1914325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IAP; IAG2; 2410001C15Rik; 2610529C04Rik; 2810482I07Rik
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Used to study primary immunodeficiency disease. Human ortholog(s) of this gene implicated in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia and congenital disorder of glycosylation Icc. Orthologous to human MAGT1 (magnesium transporter 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 16.4), limb E14.5 (RPKM 8.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Magt1 in Genome Data Viewer
    Location:
    X D; X 47.36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105011690..105055408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (105968084..106011802, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ATRX, chromatin remodeler Neighboring gene ribosomal protein 17a pseudogene Neighboring gene predicted gene, 23656 Neighboring gene STARR-seq mESC enhancer starr_47729 Neighboring gene STARR-seq mESC enhancer starr_47730 Neighboring gene STARR-positive B cell enhancer ABC_E5734 Neighboring gene cytochrome c oxidase subunit 7B Neighboring gene ATPase, copper transporting, alpha polypeptide Neighboring gene STARR-seq mESC enhancer starr_47732 Neighboring gene STARR-seq mESC enhancer starr_47734

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. Gotru SK, et al. Arterioscler Thromb Vasc Biol, 2023 Aug. PMID 37381987
    2. Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice. Gotru SK, et al. J Immunol, 2018 Apr 15. PMID 29581357
    3. Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties. Goytain A, et al. BMC Genomics, 2005 Apr 1. PMID 15804357, Free PMC Article
    4. Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters. Zocchi M, et al. Int J Mol Sci, 2022 Jan 31. PMID 35163580, Free PMC Article
    5. Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Ramírez AS, et al. Science, 2019 Dec 13. PMID 31831667

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
      Title: MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
    2. Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
      Title: Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
    3. identifed a novel gene that encodes a protein involved with Mg2+-evoked transport, MagT1; results suggest that MagT1 may provide a selective and regulated pathway for Mg2+ transport in epithelial cells[MagT1]
      Title: Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (2)  1 citation
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in magnesium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oligosaccharyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of oligosaccharyltransferase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    magnesium transporter protein 1
    Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1
    implantation-associated protein
    oligosaccharyl transferase subunit MAGT1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190409.2 → NP_001177338.2  magnesium transporter protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL670660, AL672288
      Consensus CDS
      CCDS53168.2
      UniProtKB/Swiss-Prot
      Q3UW45, Q9CQY5, Q9CWX5, Q9CZT3
      UniProtKB/TrEMBL
      A2ADH1
      Related
      ENSMUSP00000120994.3, ENSMUST00000151689.9
      Conserved Domains (1) summary
      pfam04756
      Location:42 → 330
      OST3_OST6; OST3 / OST6 family, transporter family

    2. NM_001377002.1 → NP_001363931.1  magnesium transporter protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL670660, AL672288
      UniProtKB/TrEMBL
      A2ADH1
      Conserved Domains (1) summary
      pfam04756
      Location:42 → 338
      OST3_OST6; OST3 / OST6 family, transporter family

    3. NM_001377003.1 → NP_001363932.1  magnesium transporter protein 1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL670660, AL672288
      UniProtKB/TrEMBL
      A2ADH1
      Conserved Domains (1) summary
      pfam04756
      Location:42 → 329
      OST3_OST6; OST3 / OST6 family, transporter family

    4. NM_025952.5 → NP_080228.5  magnesium transporter protein 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL670660, AL672288
      Consensus CDS
      CCDS53168.2
      UniProtKB/Swiss-Prot
      Q3UW45, Q9CQY5, Q9CWX5, Q9CZT3
      UniProtKB/TrEMBL
      A2ADH1
      Related
      ENSMUSP00000033583.8, ENSMUST00000033583.14
      Conserved Domains (1) summary
      pfam04756
      Location:42 → 330
      OST3_OST6; OST3 / OST6 family, transporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      105011690..105055408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQY5.1 GenPept UniProtKB/Swiss-Prot:Q9CQY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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