ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ST3GAL1provided by HGNC
Official Full Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1provided by HGNC
Primary source: HGNC:HGNC:10862
See related: Ensembl:ENSG00000008513 MIM:607187; AllianceGenome:HGNC:10862
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ST3O; SIAT4A; SIATFL; ST3GalA; ST3GalIA; Gal-NAc6S; ST3GalA.1; ST3GalIA,1
Summary: The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]
Expression: Broad expression in thyroid (RPKM 30.7), kidney (RPKM 13.0) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (133454848..133571887, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (134578690..134699857, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (134467091..134584130, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ST3GAL1 Promotes Malignant Phenotypes in Intrahepatic Cholangiocarcinoma.
Title: ST3GAL1 Promotes Malignant Phenotypes in Intrahepatic Cholangiocarcinoma.
Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.
Title: Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.
Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer.
Title: Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer.
ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
Title: ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1).
Title: Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1).
ST3GAL1 promotes cell migration, invasion, and TGFB1-induced epithelial-mesenchymal transition and confers paclitaxel resistance in ovarian cancer.
Title: Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-β1-induced EMT and confers paclitaxel resistance in ovarian cancer.
Data suggest that GDNF family receptor alpha 1 protein (GFRA1) is a protein target of ST3 beta-galactoside alpha-23-sialyltransferase 1 (ST3GAL1).
Title: Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells.
Expression levels of ST3Gal1 and TGFB1 were high in breast cancer tumors samples and positively correlated with each other. Shorter relapse-free survival associated with lower expression of VASN and combination of low VASN with high ST3GAL1 yielded even higher risk of recurrence. Findings illustrated a feedback regulatory loop in which TGF-beta1 upregulates ST3Gal1 to circumvent the negative impact of VASN.
Title: Sialylation of vasorin by ST3Gal1 facilitates TGF-β1-mediated tumor angiogenesis and progression.
Study demonstrates that ST3GalI regulates ovarian cancer cell migration and peritoneal dissemination via EGFR signaling.
Title: α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells.
ST3Gal I and ST6Gal I have different sialic acid donor specificity.
Title: Probing the CMP-Sialic Acid Donor Specificity of Two Human β-d-Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O- and N-Glycosylproteins.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study and meta-analysis of intraocular pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of the five-factor model of personality in young Korean women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-32958 (e-PCR)
- UniSTS:50698

WI-18021 (e-PCR)
- UniSTS:17677

SHGC-85058 (e-PCR)
- UniSTS:103443

RH78906 (e-PCR)
- UniSTS:46426

SHGC-67307 (e-PCR)
- UniSTS:89991

D8S1708 (e-PCR), detects polymorphism
- UniSTS:16536

RH17620 (e-PCR)
- UniSTS:11678

D8S1990 (e-PCR), detects polymorphism
- UniSTS:53417

RH45430 (e-PCR)
- UniSTS:72618

SHGC-151193 (e-PCR)
- UniSTS:173507

RH16392 (e-PCR)
- UniSTS:3018

WI-17797 (e-PCR)
- UniSTS:65486

RH98815 (e-PCR)
- UniSTS:89048

D15S1390 (e-PCR)
- UniSTS:474340

Clone Names

MGC9183, FLJ36548, DKFZp666E036, DKFZp779K2051

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase	IEA Inferred from Electronic Annotation more info
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	TAS Traceable Author Statement more info
enables sialyltransferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in N-acetylneuraminate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in O-glycan processing	TAS Traceable Author Statement more info
involved_in ganglioside biosynthetic process via lactosylceramide	IBA Inferred from Biological aspect of Ancestor more info
involved_in ganglioside biosynthetic process via lactosylceramide	IDA Inferred from Direct Assay more info	PubMed
involved_in keratan sulfate biosynthetic process	TAS Traceable Author Statement more info
involved_in memory B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein modification process	TAS Traceable Author Statement more info	PubMed
involved_in protein sialylation	IDA Inferred from Direct Assay more info	PubMed
involved_in sialylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sialylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in viral protein processing	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in Golgi medial cisterna membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in Golgi trans cisterna membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

Names: Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; SIAT4-A; ST3GalI; alpha 2,3-ST 1; beta-galactoside alpha-2,3-sialyltransferase 1; monosialoganglioside sialyltransferase; sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase); sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase); sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)

NP_003024.1

EC 2.4.3.2

EC 2.4.3.4

NP_775479.1

EC 2.4.3.2

EC 2.4.3.4

XP_005251082.1

EC 2.4.3.2

EC 2.4.3.4

XP_006716680.1

EC 2.4.3.2

EC 2.4.3.4

XP_016869225.1

EC 2.4.3.2

EC 2.4.3.4

XP_047278061.1

EC 2.4.3.2

EC 2.4.3.4

XP_047278062.1

EC 2.4.3.2

EC 2.4.3.4

XP_054216992.1

EC 2.4.3.2

EC 2.4.3.4

XP_054216993.1

EC 2.4.3.2

EC 2.4.3.4

XP_054216994.1

EC 2.4.3.2

EC 2.4.3.4

XP_054216995.1

EC 2.4.3.2

EC 2.4.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003033.4 → NP_003024.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

See identical proteins and their annotated locations for NP_003024.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AF186191, BC018357, BX648001

Consensus CDS

CCDS6373.1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51

Related

ENSP00000428540.1, ENST00000521180.5

Conserved Domains (1) summary

pfam00777
Location:83 → 338

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
NM_173344.3 → NP_775479.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

See identical proteins and their annotated locations for NP_775479.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AF059321, AF186191, BC018357, BX648001, CN359425

Consensus CDS

CCDS6373.1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51

Related

ENSP00000430515.1, ENST00000522652.6

Conserved Domains (1) summary

pfam00777
Location:83 → 338

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

133454848..133571887 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017013736.3 → XP_016869225.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51

Conserved Domains (1) summary

pfam00777
Location:83 → 338

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_006716617.3 → XP_006716680.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

See identical proteins and their annotated locations for XP_006716680.1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51

Related

ENSP00000497381.1, ENST00000648219.1

Conserved Domains (1) summary

pfam00777
Location:83 → 338

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_047422106.1 → XP_047278062.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51
XM_047422105.1 → XP_047278061.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51
XM_005251025.6 → XP_005251082.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

See identical proteins and their annotated locations for XP_005251082.1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51

Conserved Domains (1) summary

pfam00777
Location:83 → 338

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

134578690..134699857 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054361018.1 → XP_054216993.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51
XM_054361017.1 → XP_054216992.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51
XM_054361020.1 → XP_054216995.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51
XM_054361019.1 → XP_054216994.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

O60677, Q11201, Q9UN51