FBXW7 F-box and WD repeat domain containing 7 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: FBXW7provided by VGNC
Official Full Name: F-box and WD repeat domain containing 7provided by VGNC
Primary source: VGNC:VGNC:40797
See related: Ensembl:ENSCAFG00845007020
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	15	NC_051819.1 (50869433..51101086, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	15	NC_006597.4 (50529850..50761421, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	15	NC_049236.1 (50542860..50774097, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	15	NC_049275.1 (50130239..50363954, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	15	NC_049756.1 (50231872..50463188, complement)

Chromosome 15 - NC_051819.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Haplotype analysis and fine-mapping suggests that ILR7 and FBXW7 could be the underlying associated genes with necrotizing meningoencephalitis.
Title: Identification of novel genetic risk loci in Maltese dogs with necrotizing meningoencephalitis and evidence of a shared genetic risk across toy dog breeds.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Fbxw7 (e-PCR), detects polymorphism
- UniSTS:498235

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in ubiquitin recycling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: F-box/WD repeat-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051819.1 Reference ROS_Cfam_1.0

Range

50869433..51101086 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038688632.1 → XP_038544560.1 F-box/WD repeat-containing protein 7 isoform X1

UniProtKB/TrEMBL

A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3

Conserved Domains (3) summary

cd00200
Location:379 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:389 → 424

7WD40; WD40 repeat [structural motif]

pfam12937
Location:286 → 330

F-box-like
XM_038688633.1 → XP_038544561.1 F-box/WD repeat-containing protein 7 isoform X1

UniProtKB/TrEMBL

A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3

Related

ENSCAFP00845009912.1, ENSCAFT00845012707.1

Conserved Domains (3) summary

cd00200
Location:379 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:389 → 424

7WD40; WD40 repeat [structural motif]

pfam12937
Location:286 → 330

F-box-like
XM_038688635.1 → XP_038544563.1 F-box/WD repeat-containing protein 7 isoform X3

UniProtKB/TrEMBL

A0A8C0S7D9, A0A8I3N229

Related

ENSCAFP00845009946.1, ENSCAFT00845012754.1

Conserved Domains (3) summary

cd00200
Location:256 → 532

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:266 → 301

7WD40; WD40 repeat [structural motif]

pfam12937
Location:163 → 207

F-box-like
XM_038688634.1 → XP_038544562.1 F-box/WD repeat-containing protein 7 isoform X2

UniProtKB/TrEMBL

A0A8C0LM89, A0A8C0N3B2, A0A8I3N148

Related

ENSCAFP00845009972.1, ENSCAFT00845012788.1

Conserved Domains (3) summary

cd00200
Location:294 → 570

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:304 → 339

7WD40; WD40 repeat [structural motif]

pfam12937
Location:201 → 245

F-box-like
XM_038688636.1 → XP_038544564.1 F-box/WD repeat-containing protein 7 isoform X4

Alternate UMICH_Zoey_3.1

Genomic

NC_049275.1 Alternate UMICH_Zoey_3.1

Range

50130239..50363954 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038496633.1 → XP_038352561.1 F-box/WD repeat-containing protein 7 isoform X1

Conserved Domains (3) summary

cd00200
Location:379 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:389 → 424

7WD40; WD40 repeat [structural motif]

pfam12937
Location:286 → 330

F-box-like
XM_038496634.1 → XP_038352562.1 F-box/WD repeat-containing protein 7 isoform X1

Conserved Domains (3) summary

cd00200
Location:379 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:389 → 424

7WD40; WD40 repeat [structural motif]

pfam12937
Location:286 → 330

F-box-like
XM_038496636.1 → XP_038352564.1 F-box/WD repeat-containing protein 7 isoform X3

Conserved Domains (3) summary

cd00200
Location:256 → 532

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:266 → 301

7WD40; WD40 repeat [structural motif]

pfam12937
Location:163 → 207

F-box-like
XM_038496635.1 → XP_038352563.1 F-box/WD repeat-containing protein 7 isoform X2

Conserved Domains (3) summary

cd00200
Location:294 → 570

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:304 → 339

7WD40; WD40 repeat [structural motif]

pfam12937
Location:201 → 245

F-box-like
XM_038496637.1 → XP_038352565.1 F-box/WD repeat-containing protein 7 isoform X4

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049756.1 Alternate UNSW_CanFamBas_1.0

Range

50231872..50463188 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038622960.1 → XP_038478888.1 F-box/WD repeat-containing protein 7 isoform X1

Conserved Domains (3) summary

cd00200
Location:379 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:389 → 424

7WD40; WD40 repeat [structural motif]

pfam12937
Location:286 → 330

F-box-like
XM_038622961.1 → XP_038478889.1 F-box/WD repeat-containing protein 7 isoform X1

Conserved Domains (3) summary

cd00200
Location:379 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:389 → 424

7WD40; WD40 repeat [structural motif]

pfam12937
Location:286 → 330

F-box-like
XM_038622963.1 → XP_038478891.1 F-box/WD repeat-containing protein 7 isoform X3

Conserved Domains (3) summary

cd00200
Location:256 → 532

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:266 → 301

7WD40; WD40 repeat [structural motif]

pfam12937
Location:163 → 207

F-box-like
XM_038622962.1 → XP_038478890.1 F-box/WD repeat-containing protein 7 isoform X2

Conserved Domains (3) summary

cd00200
Location:294 → 570

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:304 → 339

7WD40; WD40 repeat [structural motif]

pfam12937
Location:201 → 245

F-box-like
XM_038622964.1 → XP_038478892.1 F-box/WD repeat-containing protein 7 isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049236.1 Alternate UU_Cfam_GSD_1.0

Range

50542860..50774097 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038559027.1 → XP_038414955.1 F-box/WD repeat-containing protein 7 isoform X1

UniProtKB/TrEMBL

A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3

Conserved Domains (3) summary

cd00200
Location:379 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:389 → 424

7WD40; WD40 repeat [structural motif]

pfam12937
Location:286 → 330

F-box-like
XM_038559028.1 → XP_038414956.1 F-box/WD repeat-containing protein 7 isoform X1

UniProtKB/TrEMBL

A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3

Conserved Domains (3) summary

cd00200
Location:379 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:389 → 424

7WD40; WD40 repeat [structural motif]

pfam12937
Location:286 → 330

F-box-like
XM_038559030.1 → XP_038414958.1 F-box/WD repeat-containing protein 7 isoform X3

UniProtKB/TrEMBL

A0A8C0S7D9, A0A8I3N229

Conserved Domains (3) summary

cd00200
Location:256 → 532

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:266 → 301

7WD40; WD40 repeat [structural motif]

pfam12937
Location:163 → 207

F-box-like
XM_038559029.1 → XP_038414957.1 F-box/WD repeat-containing protein 7 isoform X2

UniProtKB/TrEMBL

A0A8C0LM89, A0A8C0N3B2, A0A8I3N148

Conserved Domains (3) summary

cd00200
Location:294 → 570

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:304 → 339

7WD40; WD40 repeat [structural motif]

pfam12937
Location:201 → 245

F-box-like
XM_038559031.1 → XP_038414959.1 F-box/WD repeat-containing protein 7 isoform X4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

50529850..50761421 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038449238.1 → XP_038305166.1 F-box/WD repeat-containing protein 7 isoform X1

UniProtKB/TrEMBL

A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3

Conserved Domains (3) summary

cd00200
Location:379 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:389 → 424

7WD40; WD40 repeat [structural motif]

pfam12937
Location:286 → 330

F-box-like
XM_038449244.1 → XP_038305172.1 F-box/WD repeat-containing protein 7 isoform X1

UniProtKB/TrEMBL

A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3

Conserved Domains (3) summary

cd00200
Location:379 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:389 → 424

7WD40; WD40 repeat [structural motif]

pfam12937
Location:286 → 330

F-box-like
XM_532689.7 → XP_532689.2 F-box/WD repeat-containing protein 7 isoform X3

See identical proteins and their annotated locations for XP_532689.2

UniProtKB/TrEMBL

A0A8C0S7D9, A0A8I3N229

Conserved Domains (3) summary

cd00200
Location:256 → 532

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:266 → 301

7WD40; WD40 repeat [structural motif]

pfam12937
Location:163 → 207

F-box-like
XM_848531.6 → XP_853624.1 F-box/WD repeat-containing protein 7 isoform X2

UniProtKB/TrEMBL

A0A8C0LM89, A0A8C0N3B2, A0A8I3N148

Conserved Domains (3) summary

cd00200
Location:294 → 570

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:304 → 339

7WD40; WD40 repeat [structural motif]

pfam12937
Location:201 → 245

F-box-like
XM_022403517.2 → XP_022259225.1 F-box/WD repeat-containing protein 7 isoform X4