Atp4b ATPase, H+/K+ exchanging, beta polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp4bprovided by MGI
Official Full Name: ATPase, H+/K+ exchanging, beta polypeptideprovided by MGI
Primary source: MGI:MGI:88114
See related: Ensembl:ENSMUSG00000031449 AllianceGenome:MGI:88114
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ATPase activator activity and P-type potassium:proton transporter activity. Predicted to contribute to heterocyclic compound binding activity. Predicted to be involved in intracellular monoatomic cation homeostasis; monoatomic cation transmembrane transport; and pH reduction. Predicted to act upstream of or within protein glycosylation and regulation of proton transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of potassium:proton exchanging ATPase complex and sodium:potassium-exchanging ATPase complex. Is expressed in alimentary system; stomach; stomach epithelium; stomach fundus; and stomach mucosa. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; and stomach cancer. Orthologous to human ATP4B (ATPase H+/K+ transporting subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward stomach adult (RPKM 1152.3) See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 5.89 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (13436209..13446778, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (13386209..13396778, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the effect of GOAT on gastric acid secretion and expression of ghrelin in vitro, were investigated.
Title: The effect of ghrelin O-acyltransferase inhibitor on gastric H(+)-K(+)-ATPase activity and GOAT/ghrelin system in gastric mucosal cells in vitro.
H(+) /K(+) ATPase beta subunit knockout mice had decreased bone mineral content and bone mineral density, reduced cortical thickness and inferior mechanical bone strength.
Title: Decreased bone mineral density and reduced bone quality in H(+) /K(+) ATPase beta-subunit deficient mice.
Prevention of autoimmune gastritis requires the extra-thymic purging of highly autoaggressive H(+)/K(+) ATPase-specific T cells to produce a T-cell repertoire that is more susceptible to the suppressive activity of regulatory T cells.
Title: Prevention of autoimmune gastritis in mice requires extra-thymic T-cell deletion and suppression by regulatory T cells.
The endogenous H+/K+ ATPase beta autoantigen in normal mice plays a critical role in the the tolerance of pathogenic H/Kbeta-specific T cells.
Title: Endogenous H/K ATPase beta-subunit promotes T cell tolerance to the immunodominant gastritogenic determinant.
Contributes to the unique ultrastructure of secretory membranes in gastric parietal cells.
Title: The unique ultrastructure of secretory membranes in gastric parietal cells depends upon the presence of H+, K+ -ATPase.
These results may imply that the H(+),K(+)-ATPase in the cochlear lateral wall is crucial for K(+) circulation and thus plays a critical role in generation of endocochlear potential.
Title: Gastric type H+,K+-ATPase in the cochlear lateral wall is critically involved in formation of the endocochlear potential.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491296

D8Mit17 (e-PCR), detects polymorphism
- UniSTS:131375

M80251 (e-PCR)
- UniSTS:124980

Atp4b (e-PCR), detects polymorphism
- UniSTS:546671

AV080843 (e-PCR)
- UniSTS:179699

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type potassium:proton transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables heterocyclic compound binding	IEA Inferred from Electronic Annotation more info
contributes_to heterocyclic compound binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pH reduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in pH reduction	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein glycosylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of proton transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
part_of potassium:proton exchanging ATPase complex	ISO Inferred from Sequence Orthology more info
part_of sodium:potassium-exchanging ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sodium:potassium-exchanging ATPase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium-transporting ATPase subunit beta

Names: ATPase, H+/K+ transporting, beta polypeptide, gastric specific; H+,K+-ATPase; H+/K+-ATPase beta; H,K-ATPase-Beta; gastric H(+)/K(+) ATPase subunit beta; proton pump beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.