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    Tgm4 transglutaminase 4 (prostate) [ Mus musculus (house mouse) ]

    Gene ID: 331046, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tgm4provided by MGI
    Official Full Name
    transglutaminase 4 (prostate)provided by MGI
    Primary source
    MGI:MGI:3027002
    See related
    Ensembl:ENSMUSG00000025787 AllianceGenome:MGI:3027002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TGP; Eapa1; 9530008N10Rik
    Summary
    Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Acts upstream of or within mating plug formation. Predicted to be located in Golgi apparatus. Predicted to be active in collagen-containing extracellular matrix. Is expressed in anterior prostate gland; prostate gland dorsolateral lobe; and ventral prostate gland. Orthologous to human TGM4 (transglutaminase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 1.8), bladder adult (RPKM 1.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tgm4 in Genome Data Viewer
    Location:
    9 F4; 9 73.56 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122863806..122896623)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123034741..123067558)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 15 Neighboring gene predicted gene, 35691 Neighboring gene predicted gene 9856 Neighboring gene transmembrane protein 42 Neighboring gene zinc finger, DHHC domain containing 3 Neighboring gene exosome component 7 Neighboring gene STARR-seq mESC enhancer starr_25557 Neighboring gene C-type lectin domain family 3, member b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Copulatory plugs inhibit the reproductive success of rival males. Mangels R, et al. J Evol Biol, 2016 Nov. PMID 27488082, Free PMC Article
    2. Male-derived copulatory plugs enhance implantation success in female Mus musculus. Lough-Stevens M, et al. Biol Reprod, 2021 Mar 11. PMID 33355341, Free PMC Article
    3. Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+ CD25+ regulatory T cells. Setiady YY, et al. Blood, 2006 Feb 1. PMID 16223778, Free PMC Article
    4. Identification of the major TG4 cross-linking sites in the androgen-dependent SVS I exclusively expressed in mouse seminal vesicle. Tseng HC, et al. J Cell Biochem, 2009 Aug 1. PMID 19452452
    5. Genetic disruption of the copulatory plug in mice leads to severely reduced fertility. Dean MD. PLoS Genet, 2013. PMID 23341775, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TGM4 is a prostatic secretory molecule with critical role in male reproduction.
      Title: Transglutaminase 4 as a prostate autoantigen in male subfertility.
    2. male mice knockouts for transglutaminase IV (Tgm4) fail to form a copulatory plug, demonstrating that this gene is necessary for plug formation and lending a powerful new genetic tool to begin characterizing plug function
      Title: Genetic disruption of the copulatory plug in mice leads to severely reduced fertility.
    3. These studies demonstrate that tranglutaminase 2 independent activity exists in the vasculature and that Tgm1 and tgm4 are expressed in vascular tissues
      Title: Vena cava and aortic smooth muscle cells express transglutaminases 1 and 4 in addition to transglutaminase 2.
    4. The androgen-dependent SVS I is exclusively expressed in the luminal epithelium of seminal vesicle; Gln232 and Gln254 are the major TG4-reactive residues on SVS I and and TG4 is much stronger than TG2 to cross-link the glutamine residues in SVS I.
      Title: Identification of the major TG4 cross-linking sites in the androgen-dependent SVS I exclusively expressed in mouse seminal vesicle.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mating plug formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide cross-linking IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-glutamine gamma-glutamyltransferase 4
    Names
    TGase-4
    experimental autoimmune prostatitis antigen 1
    transglutaminase-4
    NP_808579.2
    XP_017168931.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177911.4 → NP_808579.2  protein-glutamine gamma-glutamyltransferase 4

      See identical proteins and their annotated locations for NP_808579.2

      Status: VALIDATED

      Source sequence(s)
      AF486627, AK035279
      Consensus CDS
      CCDS23653.1
      UniProtKB/Swiss-Prot
      B7ZP44, Q8BZH1, Q8K460
      UniProtKB/TrEMBL
      A0A0R4J071
      Related
      ENSMUSP00000026893.5, ENSMUST00000026893.6
      Conserved Domains (4) summary
      smart00460
      Location:248 → 340
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:251 → 348
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:9 → 116
      Transglut_N; Transglutaminase family
      pfam00927
      Location:574 → 670
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122863806..122896623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313442.2 → XP_017168931.1  protein-glutamine gamma-glutamyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      B7ZP44, Q8BZH1, Q8K460
      Conserved Domains (3) summary
      smart00460
      Location:327 → 419
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:86 → 195
      Transglut_N; Transglutaminase family
      pfam00927
      Location:653 → 749
      Transglut_C; Transglutaminase family, C-terminal ig like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZH1.2 GenPept UniProtKB/Swiss-Prot:Q8BZH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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