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    Sphkap SPHK1 interactor, AKAP domain containing [ Mus musculus (house mouse) ]

    Gene ID: 77629, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sphkapprovided by MGI
    Official Full Name
    SPHK1 interactor, AKAP domain containingprovided by MGI
    Primary source
    MGI:MGI:1924879
    See related
    Ensembl:ENSMUSG00000026163 AllianceGenome:MGI:1924879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SKIP; mKIAA1678; 4930544G21Rik; A930009L15Rik
    Summary
    Enables protein kinase A binding activity. Located in Z disc and mitochondrion. Is expressed in central nervous system; foot; heart; pancreas; and retina. Orthologous to human SPHKAP (SPHK1 interactor, AKAP domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 36.4), frontal lobe adult (RPKM 12.3) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sphkap in Genome Data Viewer
    Location:
    1 C5; 1 42.73 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (83233163..83385853, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (83255442..83408411, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dynein assembly factor with WDR repeat domains 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene mitochondrial ribosome recycling factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_01496 Neighboring gene STARR-seq mESC enhancer starr_01497 Neighboring gene STARR-seq mESC enhancer starr_01498 Neighboring gene STARR-seq mESC enhancer starr_01499 Neighboring gene STARR-seq mESC enhancer starr_01500 Neighboring gene STARR-seq mESC enhancer starr_01501 Neighboring gene STARR-seq mESC enhancer starr_01502 Neighboring gene predicted gene, 24555 Neighboring gene predicted gene, 51636

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion. Wang Y, et al. Sci Rep, 2017 Apr 10. PMID 28396589, Free PMC Article
    2. Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion. Liu Y, et al. FASEB J, 2019 May. PMID 30789757
    3. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Means CK, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22084075, Free PMC Article
    4. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Terami H, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17286962
    5. FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Araujo DJ, et al. Genes Dev, 2015 Oct 15. PMID 26494785, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of SKIP improves glucose tolerance through increasing not only insulin secretion but also GIP and GLP-1 secretions.
      Title: Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion.
    2. These results indicate that SKIP modulates GSIS by a pathway distinct from that of cAMP-, PDE- and sphingosine kinase-dependent pathways.
      Title: Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase A binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A-kinase anchor protein SPHKAP
    Names
    SPHK1-interactor and AKAP domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356547.2 → NP_001343476.1  A-kinase anchor protein SPHKAP isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC138359, AC154144
      UniProtKB/Swiss-Prot
      Q6NSW3, Q6PAM6, Q6PAP7, Q80TA7, Q80XT3, Q8BYQ9, Q8BZL6, Q8C1G7
      Conserved Domains (1) summary
      cl14906
      Location:1580 → 1680
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    2. NM_001405283.1 → NP_001392212.1  A-kinase anchor protein SPHKAP isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138359, AC154144

    3. NM_001405284.1 → NP_001392213.1  A-kinase anchor protein SPHKAP isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC138359, AC154144

    4. NM_001405285.1 → NP_001392214.1  A-kinase anchor protein SPHKAP isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC138359, AC154144

    5. NM_001405286.1 → NP_001392215.1  A-kinase anchor protein SPHKAP isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC138359, AC154144

    6. NM_001405287.1 → NP_001392216.1  A-kinase anchor protein SPHKAP isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC138359, AC154144

    7. NM_172430.5 → NP_766018.3  A-kinase anchor protein SPHKAP isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138359, AC154144
      Consensus CDS
      CCDS48298.1
      UniProtKB/Swiss-Prot
      Q6NSW3, Q6PAM6, Q6PAP7, Q80TA7, Q80XT3, Q8BYQ9, Q8BZL6, Q8C1G7
      UniProtKB/TrEMBL
      E9PUC4
      Related
      ENSMUSP00000124872.2, ENSMUST00000160953.8
      Conserved Domains (1) summary
      cl14906
      Location:1555 → 1655
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      83233163..83385853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NSW3.2 GenPept UniProtKB/Swiss-Prot:Q6NSW3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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