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    Slc22a8 solute carrier family 22 (organic anion transporter), member 8 [ Mus musculus (house mouse) ]

    Gene ID: 19879, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc22a8provided by MGI
    Official Full Name
    solute carrier family 22 (organic anion transporter), member 8provided by MGI
    Primary source
    MGI:MGI:1336187
    See related
    Ensembl:ENSMUSG00000063796 AllianceGenome:MGI:1336187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oat3; Roct
    Summary
    Enables antiporter activity and organic anion transmembrane transporter activity. Predicted to be involved in glutathione transport; prostaglandin transport; and quaternary ammonium group transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; liver; spleen; and thyroid gland. Orthologous to human SLC22A8 (solute carrier family 22 member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward kidney adult (RPKM 202.2) See more
    Orthologs
    human all
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    Genomic context

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    See Slc22a8 in Genome Data Viewer
    Location:
    19 A; 19 5.44 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8568576..8589199)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8591254..8611835)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57666 Neighboring gene solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 pseudogene Neighboring gene predicted gene, 36394 Neighboring gene solute carrier family 22 (organic anion transporter), member 6 Neighboring gene RIKEN cDNA 9830166K06 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin. Vanwert AL, et al. Mol Pharmacol, 2008 Jul. PMID 18381565, Free PMC Article
    2. Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Kobayashi Y, et al. Drug Metab Dispos, 2004 May. PMID 15100168
    3. Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice. Sykes D, et al. Am J Physiol Renal Physiol, 2004 May. PMID 15075193
    4. Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Wu W, et al. Drug Metab Dispos, 2013 Oct. PMID 23920220, Free PMC Article
    5. Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. Ohtsuki S, et al. J Pharmacol Exp Ther, 2004 Jun. PMID 14762099

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3.
      Title: Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3.
    2. Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.
      Title: Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.
    3. Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.
      Title: Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.
    4. OAT3 increases the glucosuric effect of empagliflozin, which may relate to the partial overlap of its localization with SGLT2 and thus OAT3-mediated tubular secretion of empagliflozin in the early proximal tubule.
      Title: Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin.
    5. vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol.
      Title: Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.
    6. OCT2-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3, is reported.
      Title: Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.
    7. OAT1 plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney
      Title: The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis.
    8. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 and OAT3).
      Title: Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice.
    9. Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.
      Title: The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction.
    10. Oat3 also plays a role in bioenergetic pathways.
      Title: Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables organic anion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables prostaglandin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prostaglandin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables quaternary ammonium group transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:inorganic anion antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xenobiotic transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prostaglandin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in quaternary ammonium group transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    organic anion transporter 3
    Names
    organic anion/dicarboxylate exchanger
    reduced in osteosclerosis transporter
    solute carrier family 22, member 8

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164634.2 → NP_001158106.1  organic anion transporter 3 isoform 1

      See identical proteins and their annotated locations for NP_001158106.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC025794, AC125136
      Consensus CDS
      CCDS29537.1
      UniProtKB/Swiss-Prot
      O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9
      Related
      ENSMUSP00000131045.2, ENSMUST00000170817.2
      Conserved Domains (1) summary
      TIGR00898
      Location:11 → 503
      2A0119; cation transport protein

    2. NM_001164635.2 → NP_001158107.1  organic anion transporter 3 isoform 1

      See identical proteins and their annotated locations for NP_001158107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC025794, AC125136
      Consensus CDS
      CCDS29537.1
      UniProtKB/Swiss-Prot
      O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9
      Conserved Domains (1) summary
      TIGR00898
      Location:11 → 503
      2A0119; cation transport protein

    3. NM_001411470.1 → NP_001398399.1  organic anion transporter 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC025794, AC125136
      UniProtKB/Swiss-Prot
      O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9

    4. NM_001411471.1 → NP_001398400.1  organic anion transporter 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC025794, AC125136

    5. NM_001411472.1 → NP_001398401.1  organic anion transporter 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC025794, AC125136

    6. NM_001411473.1 → NP_001398402.1  organic anion transporter 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC025794, AC125136

    7. NM_031194.6 → NP_112471.3  organic anion transporter 3 isoform 1

      See identical proteins and their annotated locations for NP_112471.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC025794, AC125136
      Consensus CDS
      CCDS29537.1
      UniProtKB/Swiss-Prot
      O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9
      Related
      ENSMUSP00000010251.4, ENSMUST00000010251.11
      Conserved Domains (1) summary
      TIGR00898
      Location:11 → 503
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8568576..8589199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004940127.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88909.2 GenPept UniProtKB/Swiss-Prot:O88909

    Gene LinkOut

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