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    Zfp18 zinc finger protein 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303226, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp18provided by RGD
    Official Full Name
    zinc finger protein 18provided by RGD
    Primary source
    RGD:1305130
    See related
    EnsemblRapid:ENSRNOG00000003981 AllianceGenome:RGD:1305130
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf18; Zfp535; Zkscan6
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF18 (zinc finger protein 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 77.6), Lung (RPKM 68.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp18 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (50972531..50994796)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (50473428..50495707)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (52327668..52350944)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554159 Neighboring gene THAP domain-containing protein 5-like Neighboring gene mitogen activated protein kinase kinase 4 Neighboring gene dynein, axonemal, heavy chain 9 Neighboring gene uncharacterized LOC120095122 Neighboring gene shisa family member 6 Neighboring gene uncharacterized LOC134480810

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 18
    Names
    zinc finger protein 535
    zinc finger with KRAB and SCAN domains 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012008.1 → NP_001012008.1  zinc finger protein 18

      See identical proteins and their annotated locations for NP_001012008.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081874
      UniProtKB/Swiss-Prot
      Q642B9
      UniProtKB/TrEMBL
      A6HFG0
      Conserved Domains (7) summary
      smart00431
      Location:37 → 144
      SCAN; leucine rich region
      cd07765
      Location:226 → 256
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:428 → 521
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:527 → 549
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:37 → 125
      SCAN; SCAN domain
      pfam13465
      Location:513 → 537
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      50972531..50994796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246695.5 → XP_006246757.1  zinc finger protein 18 isoform X1

      See identical proteins and their annotated locations for XP_006246757.1

      UniProtKB/Swiss-Prot
      Q642B9
      UniProtKB/TrEMBL
      A6HFG0
      Related
      ENSRNOP00000005518.4, ENSRNOT00000005518.6
      Conserved Domains (7) summary
      smart00431
      Location:37 → 144
      SCAN; leucine rich region
      cd07765
      Location:226 → 256
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:428 → 521
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:527 → 549
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:37 → 125
      SCAN; SCAN domain
      pfam13465
      Location:513 → 537
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006246696.5 → XP_006246758.1  zinc finger protein 18 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q1J6
      Conserved Domains (7) summary
      smart00431
      Location:37 → 144
      SCAN; leucine rich region
      cd07765
      Location:226 → 256
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:427 → 520
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:472 → 492
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:526 → 548
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:37 → 125
      SCAN; SCAN domain
      pfam13465
      Location:512 → 536
      zf-H2C2_2; Zinc-finger double domain

    3. XM_006246697.5 → XP_006246759.1  zinc finger protein 18 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GAI4
      Related
      ENSRNOP00000084497.1, ENSRNOT00000103112.2
      Conserved Domains (7) summary
      smart00431
      Location:37 → 144
      SCAN; leucine rich region
      cd07765
      Location:226 → 256
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:390 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:435 → 455
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:489 → 511
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:37 → 125
      SCAN; SCAN domain
      pfam13465
      Location:475 → 499
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q642B9.1 GenPept UniProtKB/Swiss-Prot:Q642B9

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