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    ILV5 ketol-acid reductoisomerase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851069, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ILV5
    Official Full Name
    ketol-acid reductoisomerase
    Primary source
    SGD:S000004347
    Locus tag
    YLR355C
    See related
    AllianceGenome:SGD:S000004347; FungiDB:YLR355C; VEuPathDB:YLR355C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables double-stranded DNA binding activity and ketol-acid reductoisomerase activity. Involved in branched-chain amino acid biosynthetic process and mitochondrial genome maintenance. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ILV5 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (838066..839253, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Bud8p Neighboring gene sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 Neighboring gene Atg33p Neighboring gene Rsc2p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ILV5 gene of Saccharomyces cerevisiae is highly expressed. Petersen JG, et al. Nucleic Acids Res, 1986 Dec 22. PMID 3027658, Free PMC Article
    2. Mutational bisection of the mitochondrial DNA stability and amino acid biosynthetic functions of ilv5p of budding yeast. Bateman JM, et al. Genetics, 2002 Jul. PMID 12136009, Free PMC Article
    3. Cloning and molecular analysis of two different ILV5 genes from a brewing strain of Saccharomyces cerevisiae. Xie Q, et al. Curr Genet, 1994 Nov-Dec. PMID 7874731
    4. Tandem integration of multiple ILV5 copies and elevated transcription in polyploid yeast. Mithieux SM, et al. Yeast, 1995 Apr 15. PMID 7785331
    5. Targeting of mitochondrial Saccharomyces cerevisiae Ilv5p to the cytosol and its effect on vicinal diketone formation in brewing. Omura F. Appl Microbiol Biotechnol, 2008 Mar. PMID 18193418

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. direct binding of Ilv5p can aid in the maintenance and stabilization of mtDNA
      Title: Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ketol-acid reductoisomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ketol-acid reductoisomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ketol-acid reductoisomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-valine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-valine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branched-chain amino acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isoleucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ketol-acid reductoisomerase
    NP_013459.1
    • Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      838066..839253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182244.1 → NP_013459.1  TPA: ketol-acid reductoisomerase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013459.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYZ3, P06168
      UniProtKB/TrEMBL
      A7A1N3, B3RHM4, B5VNP5, C7GRY0, C8ZDW2, E9P9Y3, G2WJH3, N1NYP1
      Conserved Domains (1) summary
      TIGR00465
      Location:75 → 395
      ilvC; ketol-acid reductoisomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06168.1

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