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    FKS1 1,3-beta-D-glucan synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851055, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FKS1
    Official Full Name
    1,3-beta-D-glucan synthase
    Primary source
    SGD:S000004334
    Locus tag
    YLR342W
    See related
    AllianceGenome:SGD:S000004334; FungiDB:YLR342W; VEuPathDB:YLR342W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CND1; CWH53; ETG1; GSC1; PBR1
    Summary
    Enables 1,3-beta-D-glucan synthase activity. Involved in (1->3)-beta-D-glucan biosynthetic process; positive regulation of endocytosis; and regulation of cell size. Located in several cellular components, including actin cortical patch; cellular bud neck; and cellular bud tip. Part of 1,3-beta-D-glucan synthase complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FKS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (809997..815627)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ribosomal protein P0 Neighboring gene Spo77p Neighboring gene uncharacterized protein Neighboring gene 1,3-beta-glucanosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role for Fks1 in the intrinsic echinocandin resistance of Fusarium solani as evidenced by hybrid expression in Saccharomyces cerevisiae. Katiyar SK, et al. Antimicrob Agents Chemother, 2009 May. PMID 19258277, Free PMC Article
    2. RNA-Seq analysis of global transcriptomic changes suggests a roles for the MAPK pathway and carbon metabolism in cell wall maintenance in a Saccharomyces cerevisiae FKS1 mutant. Huang C, et al. Biochem Biophys Res Commun, 2018 Jun 7. PMID 29665361
    3. A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase. Douglas CM, et al. J Bacteriol, 1994 Sep. PMID 8083161, Free PMC Article
    4. Nikkomycin Z supersensitivity of an echinocandin-resistant mutant of Saccharomyces cerevisiae. el-Sherbeini M, et al. Antimicrob Agents Chemother, 1995 Jan. PMID 7695307, Free PMC Article
    5. FKS1 mutations responsible for selective resistance of Saccharomyces cerevisiae to the novel 1,3-beta-glucan synthase inhibitor arborcandin C. Ohyama T, et al. Antimicrob Agents Chemother, 2004 Jan. PMID 14693557, Free PMC Article

    See all (219) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and mechanistic insights into fungal beta-1,3-glucan synthase FKS1.
      Title: Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1.
    2. the mitotic spindle breakage observed in endocytosis mutants can be rescued either by deleting or inhibiting the activities of, CHS2, CHS3 and FKS1, which are involved in septum formation. The findings from our study highlight the importance of timely endocytosis of cytokinetic enzymes at the division site in safeguarding mitotic spindle integrity during mitotic exit.
      Title: Timely Endocytosis of Cytokinetic Enzymes Prevents Premature Spindle Breakage during Mitotic Exit.
    3. Both the N terminus and the C terminus are essential for Fks1 function.
      Title: Topological and mutational analysis of Saccharomyces cerevisiae Fks1.
    4. Fks1p consists of multiple domains that are required for cell wall construction and cellular morphogenesis.
      Title: Multiple functional domains of the yeast l,3-beta-glucan synthase subunit Fks1p revealed by quantitative phenotypic analysis of temperature-sensitive mutants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1,3-beta-D-glucan synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1,3-beta-D-glucan synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1,3-beta-D-glucan synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1,3-beta-D-glucan synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in (1->3)-beta-D-glucan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in (1->3)-beta-D-glucan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in (1->3)-beta-D-glucan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in (1->3)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall polysaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 1,3-beta-D-glucan synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of 1,3-beta-D-glucan synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery HDA PubMed 
    located_in cellular bud HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1,3-beta-D-glucan synthase
    NP_013446.1
    • Catalytic subunit of 1,3-beta-D-glucan synthase; transfers glucose from UDP-glucose to growing chains of glucan via beta-1,3-glycosidic linkages, translocating polymerized beta-1,3-glucan to the extracellular space; role in cell wall synthesis and maintenance; functionally redundant with alternate catalytic subunit Gsc2p; activity regulated by Rho1p, a subunit of the synthase complex; localizes to sites of cell wall remodeling; contains a cellulose-synthase-like fold; antifungal drug target

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      809997..815627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182231.1 → NP_013446.1  TPA: 1,3-beta-D-glucan synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013446.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYY0, P38631, Q53YZ4, Q6TKS9, Q6TKT0
      UniProtKB/TrEMBL
      G2WJG0, N1P018
      Conserved Domains (3) summary
      pfam02364
      Location:808 → 1631
      Glucan_synthase; 1,3-beta-glucan synthase component
      pfam12273
      Location:18 → 80
      RCR; Chitin synthesis regulation, resistance to Congo red
      pfam14288
      Location:300 → 409
      FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38631.2

    Gene LinkOut

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