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    Bptf bromodomain PHD finger transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 207165, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bptfprovided by MGI
    Official Full Name
    bromodomain PHD finger transcription factorprovided by MGI
    Primary source
    MGI:MGI:2444008
    See related
    Ensembl:ENSMUSG00000040481 AllianceGenome:MGI:2444008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Falz; 9430093H17Rik
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Predicted to contribute to ATP-dependent activity, acting on DNA. Acts upstream of or within anterior/posterior pattern specification; embryonic placenta development; and endoderm development. Predicted to be located in several cellular components, including cell body; dendrite; and perinuclear region of cytoplasm. Predicted to be part of NURF complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and retina. Used to study neurodevelopmental disorder with dysmorphic facies and distal limb anomalies. Human ortholog(s) of this gene implicated in Kaposi's sarcoma; alcohol dependence; and neurodevelopmental disorder with dysmorphic facies and distal limb anomalies. Orthologous to human BPTF (bromodomain PHD finger transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 10.4), CNS E11.5 (RPKM 10.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bptf in Genome Data Viewer
    Location:
    11 E1; 11 70.11 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106923907..107022982, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (107033081..107132147, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4007 Neighboring gene STARR-seq mESC enhancer starr_30953 Neighboring gene RIKEN cDNA 1810010H24 gene Neighboring gene nuclear encoded tRNA arginine 1 (anticodon CCG) Neighboring gene STARR-positive B cell enhancer ABC_E9377 Neighboring gene STARR-positive B cell enhancer mm9_chr11:106905708-106906009 Neighboring gene STARR-positive B cell enhancer ABC_E2373 Neighboring gene STARR-positive B cell enhancer ABC_E5290 Neighboring gene STARR-positive B cell enhancer ABC_E10725 Neighboring gene STARR-seq mESC enhancer starr_30956 Neighboring gene STARR-positive B cell enhancer ABC_E10726 Neighboring gene STARR-seq mESC enhancer starr_30959 Neighboring gene STARR-seq mESC enhancer starr_30962 Neighboring gene predicted gene 11715 Neighboring gene nucleolar protein 11 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BPTF Depletion Enhances T-cell-Mediated Antitumor Immunity. Mayes K, et al. Cancer Res, 2016 Nov 1. PMID 27651309, Free PMC Article
    2. BPTF Is Essential for T Cell Homeostasis and Function. Wu B, et al. J Immunol, 2016 Dec 1. PMID 27799308, Free PMC Article
    3. The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Xu B, et al. Stem Cell Reports, 2018 Mar 13. PMID 29456179, Free PMC Article
    4. Chromatin remodeling complex NURF regulates thymocyte maturation. Landry JW, et al. Genes Dev, 2011 Feb 1. PMID 21289071, Free PMC Article
    5. Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells. Koludrovic D, et al. PLoS Genet, 2015 Oct. PMID 26440048, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation.
      Title: NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation.
    2. Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma.
      Title: Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma.
    3. Bptf determines oncogenic addiction in aggressive B-cell lymphomas.
      Title: Bptf determines oncogenic addiction in aggressive B-cell lymphomas.
    4. An essential requirement of the chromatin remodeler BPTF and NURF for activation of "stemness" gene-expression programs and proper function of adult HSCs.
      Title: The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells.
    5. This study implicates BPTF in maintaining the unique epigenetic state of mammary gland stem cells.
      Title: BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.
    6. enhanced activity was observed for individual CD8(+) T-cell clones from mice bearing BPTF-silenced tumors.
      Title: BPTF Depletion Enhances T-cell-Mediated Antitumor Immunity.
    7. These findings therefore reveal a vital role for BPTF in T and Treg cell function and immune homeostasis.
      Title: BPTF Is Essential for T Cell Homeostasis and Function.
    8. We find that the melanocyte stem cells from these animals are abnormal and that once they are stimulated at anagen, Bptf is required to ensure the expression of melanocyte markers and their differentiation into mature adult melanocytes.
      Title: Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells.
    9. NURF regulation occurs partly through physical and functional interactions with the ubiquitous and multivalent factors Ctcf and cohesin
      Title: Functional interactions between NURF and Ctcf regulate gene expression.
    10. study concludes that Bptf likely regulates genes and signaling pathways essential for the development of key tissues of the early mouse embryo
      Title: Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC54978

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NURF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NURF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleosome-remodeling factor subunit BPTF
    Names
    fetal Alzheimer antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359590.2 → NP_001346519.1  nucleosome-remodeling factor subunit BPTF isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596116
      UniProtKB/TrEMBL
      E5D6T0
      Conserved Domains (8) summary
      cd05509
      Location:2673 → 2773
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:252 → 311
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2611 → 2657
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:1965 → 2386
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl25742
      Location:2406 → 2528
      ERM; Ezrin/radixin/moesin family

    2. NM_176850.3 → NP_789820.2  nucleosome-remodeling factor subunit BPTF isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596116
      Consensus CDS
      CCDS48964.1
      UniProtKB/TrEMBL
      A2A655, E9Q6A7
      Related
      ENSMUSP00000052303.9, ENSMUST00000057892.15
      Conserved Domains (6) summary
      cd05509
      Location:2806 → 2906
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2744 → 2790
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam03955
      Location:2080 → 2169
      Adeno_PIX; Adenovirus hexon-associated protein (IX)
      pfam15612
      Location:351 → 400
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106923907..107022982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532690.3 → XP_006532753.1  nucleosome-remodeling factor subunit BPTF isoform X23

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (9) summary
      cd05509
      Location:2798 → 2898
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2736 → 2782
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam03157
      Location:2140 → 2518
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2531 → 2653
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    2. XM_036156484.1 → XP_036012377.1  nucleosome-remodeling factor subunit BPTF isoform X20

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (9) summary
      cd05509
      Location:2856 → 2956
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:252 → 311
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2794 → 2840
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:2140 → 2518
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2531 → 2656
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      NF033845
      Location:579 → 752
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    3. XM_006532686.4 → XP_006532749.1  nucleosome-remodeling factor subunit BPTF isoform X12

      UniProtKB/TrEMBL
      A2A654
      Related
      ENSMUSP00000102374.2, ENSMUST00000106763.8
      Conserved Domains (9) summary
      cd05509
      Location:2931 → 3031
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2869 → 2915
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2192 → 2555
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2642 → 2782
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    4. XM_017314399.3 → XP_017169888.1  nucleosome-remodeling factor subunit BPTF isoform X19

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      cd05509
      Location:2852 → 2952
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2790 → 2836
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam03157
      Location:2194 → 2572
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2585 → 2707
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2038 → 2345
      DUF5585; Family of unknown function (DUF5585)

    5. XM_030245733.2 → XP_030101593.1  nucleosome-remodeling factor subunit BPTF isoform X16

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      cd05509
      Location:2910 → 3010
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2848 → 2894
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam03157
      Location:2194 → 2572
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2585 → 2707
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2038 → 2345
      DUF5585; Family of unknown function (DUF5585)

    6. XM_006532685.2 → XP_006532748.1  nucleosome-remodeling factor subunit BPTF isoform X11

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2923 → 2969
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2246 → 2609
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2696 → 2836
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2038 → 2345
      DUF5585; Family of unknown function (DUF5585)
      cl02556
      Location:2985 → 3030
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    7. XM_006532680.2 → XP_006532743.1  nucleosome-remodeling factor subunit BPTF isoform X6

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      cd05509
      Location:2985 → 3085
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2923 → 2969
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2246 → 2609
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2696 → 2836
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2038 → 2345
      DUF5585; Family of unknown function (DUF5585)

    8. XM_006532684.4 → XP_006532747.1  nucleosome-remodeling factor subunit BPTF isoform X10

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      cd05509
      Location:2985 → 3085
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2923 → 2969
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2246 → 2609
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2696 → 2836
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2038 → 2345
      DUF5585; Family of unknown function (DUF5585)

    9. XM_006532678.2 → XP_006532741.1  nucleosome-remodeling factor subunit BPTF isoform X4

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2981 → 3027
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2246 → 2609
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2696 → 2836
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2038 → 2345
      DUF5585; Family of unknown function (DUF5585)
      cl02556
      Location:3043 → 3088
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    10. XM_006532675.2 → XP_006532738.1  nucleosome-remodeling factor subunit BPTF isoform X1

      See identical proteins and their annotated locations for XP_006532738.1

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      cd05509
      Location:3043 → 3143
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2981 → 3027
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2246 → 2609
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2696 → 2836
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2038 → 2345
      DUF5585; Family of unknown function (DUF5585)

    11. XM_006532677.4 → XP_006532740.1  nucleosome-remodeling factor subunit BPTF isoform X3

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      cd05509
      Location:3043 → 3143
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2981 → 3027
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2246 → 2609
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2696 → 2836
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2038 → 2345
      DUF5585; Family of unknown function (DUF5585)

    12. XM_006532687.3 → XP_006532750.1  nucleosome-remodeling factor subunit BPTF isoform X14

      UniProtKB/TrEMBL
      A2A655
      Conserved Domains (9) summary
      cd05509
      Location:2918 → 3018
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2856 → 2902
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2121 → 2484
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2571 → 2711
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:1913 → 2220
      DUF5585; Family of unknown function (DUF5585)

    13. XM_006532683.3 → XP_006532746.1  nucleosome-remodeling factor subunit BPTF isoform X9

      UniProtKB/TrEMBL
      A2A655
      Conserved Domains (10) summary
      cd05509
      Location:2979 → 3079
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2917 → 2963
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2182 → 2545
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2632 → 2772
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:1974 → 2281
      DUF5585; Family of unknown function (DUF5585)
      NF000535
      Location:519 → 653
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

    14. XM_006532682.3 → XP_006532745.1  nucleosome-remodeling factor subunit BPTF isoform X8

      UniProtKB/TrEMBL
      A2A655
      Conserved Domains (10) summary
      cd05509
      Location:2980 → 3080
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2918 → 2964
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2183 → 2546
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2633 → 2773
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:1975 → 2282
      DUF5585; Family of unknown function (DUF5585)
      NF000535
      Location:519 → 687
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

    15. XM_006532681.3 → XP_006532744.1  nucleosome-remodeling factor subunit BPTF isoform X7

      UniProtKB/TrEMBL
      A2A655
      Conserved Domains (9) summary
      cd05509
      Location:2981 → 3081
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2919 → 2965
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2184 → 2547
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2634 → 2774
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:1976 → 2283
      DUF5585; Family of unknown function (DUF5585)

    16. XM_006532676.3 → XP_006532739.1  nucleosome-remodeling factor subunit BPTF isoform X2

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      cd05509
      Location:3042 → 3142
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 748
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2980 → 3026
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2245 → 2608
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2695 → 2835
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2037 → 2344
      DUF5585; Family of unknown function (DUF5585)

    17. XM_006532679.3 → XP_006532742.1  nucleosome-remodeling factor subunit BPTF isoform X5

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (9) summary
      cd05509
      Location:2989 → 3089
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2927 → 2973
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam09606
      Location:2192 → 2555
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam13868
      Location:2642 → 2782
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    18. XM_036156488.1 → XP_036012381.1  nucleosome-remodeling factor subunit BPTF isoform X26

      UniProtKB/TrEMBL
      E5D6T0
      Conserved Domains (8) summary
      cd05509
      Location:2731 → 2831
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:252 → 311
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2669 → 2715
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:2015 → 2393
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2406 → 2531
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    19. XM_036156486.1 → XP_036012379.1  nucleosome-remodeling factor subunit BPTF isoform X24

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (8) summary
      cd05509
      Location:2794 → 2894
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:252 → 311
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2732 → 2778
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:2078 → 2456
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2469 → 2594
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    20. XM_006532689.3 → XP_006532752.1  nucleosome-remodeling factor subunit BPTF isoform X18

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (9) summary
      cd05509
      Location:2856 → 2956
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2794 → 2840
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam03157
      Location:2140 → 2518
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2531 → 2653
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    21. XM_006532688.3 → XP_006532751.1  nucleosome-remodeling factor subunit BPTF isoform X15

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      cd05509
      Location:2910 → 3010
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2848 → 2894
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam03157
      Location:2194 → 2572
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2585 → 2707
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2038 → 2345
      DUF5585; Family of unknown function (DUF5585)

    22. XM_030245735.2 → XP_030101595.1  nucleosome-remodeling factor subunit BPTF isoform X22

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (10) summary
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2790 → 2836
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam02791
      Location:253 → 309
      DDT; DDT domain
      pfam03157
      Location:2194 → 2572
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2585 → 2707
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      pfam17823
      Location:2038 → 2345
      DUF5585; Family of unknown function (DUF5585)
      cl02556
      Location:2852 → 2897
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    23. XM_036156483.1 → XP_036012376.1  nucleosome-remodeling factor subunit BPTF isoform X17

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (9) summary
      smart00571
      Location:252 → 311
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2848 → 2894
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:2194 → 2572
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2585 → 2710
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      NF033845
      Location:579 → 752
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl02556
      Location:2910 → 2955
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    24. XM_036156487.1 → XP_036012380.1  nucleosome-remodeling factor subunit BPTF isoform X25

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (9) summary
      cd05509
      Location:2798 → 2898
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:252 → 311
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2736 → 2782
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:2140 → 2518
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2531 → 2656
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      NF033845
      Location:579 → 752
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    25. XM_036156485.1 → XP_036012378.1  nucleosome-remodeling factor subunit BPTF isoform X21

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (9) summary
      smart00571
      Location:252 → 311
      DDT; domain in different transcription and chromosome remodeling factors
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2794 → 2840
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:2140 → 2518
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2531 → 2656
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl02556
      Location:2856 → 2901
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    26. XM_036156482.1 → XP_036012375.1  nucleosome-remodeling factor subunit BPTF isoform X13

      UniProtKB/TrEMBL
      A2A654
      Conserved Domains (9) summary
      cd05509
      Location:2931 → 3031
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:252 → 311
      DDT; domain in different transcription and chromosome remodeling factors
      COG5271
      Location:578 → 749
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd15559
      Location:404 → 446
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:2869 → 2915
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:2140 → 2518
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:2643 → 2789
      TPH; Trichohyalin-plectin-homology domain
      pfam15612
      Location:356 → 393
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:468 → 536
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080832.1: Suppressed sequence

      Description
      NM_001080832.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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