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    Jcad junctional cadherin 5 associated [ Mus musculus (house mouse) ]

    Gene ID: 240185, updated on 12-Nov-2024

    Summary

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    Official Symbol
    Jcadprovided by MGI
    Official Full Name
    junctional cadherin 5 associatedprovided by MGI
    Primary source
    MGI:MGI:2685174
    See related
    Ensembl:ENSMUSG00000033960 AllianceGenome:MGI:2685174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm328; mKIAA1462; 1110056P05Rik; 9430020K01Rik
    Summary
    Involved in positive regulation of sprouting angiogenesis. Located in cell-cell junction. Is expressed in meninges; tail mesenchyme; and vertebral axis musculature. Orthologous to human JCAD (junctional cadherin 5 associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 23.0), cortex adult (RPKM 11.1) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Jcad in Genome Data Viewer
    Location:
    18 A1; 18 3.01 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4590775..4682869)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4590792..4682869)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protein arginine N-methyltransferase 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43680 Neighboring gene predicted gene, 41658 Neighboring gene STARR-seq mESC enhancer starr_43681 Neighboring gene STARR-seq mESC enhancer starr_43682 Neighboring gene STARR-seq mESC enhancer starr_43683 Neighboring gene predicted gene 5047 Neighboring gene STARR-positive B cell enhancer ABC_E7570 Neighboring gene STARR-seq mESC enhancer starr_43684 Neighboring gene predicted gene 10556 Neighboring gene predicted gene, 34269

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. JCAD deficiency delayed liver regenerative repair through the Hippo-YAP signalling pathway. Zhang L, et al. Clin Transl Med, 2024 Mar. PMID 38509842, Free PMC Article
    2. JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis. Xie L, et al. Clin Mol Hepatol, 2024 Apr. PMID 38190829, Free PMC Article
    3. A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction. Douglas G, et al. Cardiovasc Res, 2020 Sep 1. PMID 31584065, Free PMC Article
    4. Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo. Hara T, et al. Arterioscler Thromb Vasc Biol, 2017 Sep. PMID 28705794
    5. JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. Liberale L, et al. Eur Heart J, 2023 May 21. PMID 36469488, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of JCAD/KIAA1462 Protects the Lung from Acute and Chronic Consequences of Chronic Obstructive Pulmonary Disease.
      Title: Loss of JCAD/KIAA1462 Protects the Lung from Acute and Chronic Consequences of Chronic Obstructive Pulmonary Disease.
    2. JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis.
      Title: JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis.
    3. JCAD deficiency delayed liver regenerative repair through the Hippo-YAP signalling pathway.
      Title: JCAD deficiency delayed liver regenerative repair through the Hippo-YAP signalling pathway.
    4. JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
      Title: JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
    5. A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.
      Title: A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.
    6. JCAD has a redundant functional role in physiological angiogenesis but serves a pivotal role in pathological angiogenic process after birth.
      Title: Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.
    7. These results indicate that JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. This study also suggests the implication of endothelial cell-cell adhesion in coronary artery disease.
      Title: A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1462

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    junctional cadherin 5-associated protein
    Names
    junctional protein associated with coronary artery disease

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081963.1 → NP_001075432.1  junctional cadherin 5-associated protein

      See identical proteins and their annotated locations for NP_001075432.1

      Status: VALIDATED

      Source sequence(s)
      AC147227, AK220394, BU757028
      Consensus CDS
      CCDS37719.1
      UniProtKB/Swiss-Prot
      Q5DTX6
      UniProtKB/TrEMBL
      B7ZN02
      Related
      ENSMUSP00000038613.6, ENSMUST00000037029.7
      Conserved Domains (1) summary
      pfam15351
      Location:1 → 1309
      JCAD; Junctional protein associated with coronary artery disease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      4590775..4682869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525904.4 → XP_006525967.1  junctional cadherin 5-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006525967.1

      UniProtKB/Swiss-Prot
      Q5DTX6
      UniProtKB/TrEMBL
      B7ZN02
      Related
      ENSMUSP00000157313.2, ENSMUST00000234153.2
      Conserved Domains (1) summary
      pfam15351
      Location:1 → 1309
      JCAD; Junctional protein associated with coronary artery disease

    2. XM_006525903.4 → XP_006525966.1  junctional cadherin 5-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006525966.1

      UniProtKB/Swiss-Prot
      Q5DTX6
      UniProtKB/TrEMBL
      B7ZN02
      Conserved Domains (1) summary
      pfam15351
      Location:1 → 1309
      JCAD; Junctional protein associated with coronary artery disease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DTX6.2 GenPept UniProtKB/Swiss-Prot:Q5DTX6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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