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    Polr2e polymerase (RNA) II (DNA directed) polypeptide E [ Mus musculus (house mouse) ]

    Gene ID: 66420, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Polr2eprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Eprovided by MGI
    Primary source
    MGI:MGI:1913670
    See related
    Ensembl:ENSMUSG00000004667 AllianceGenome:MGI:1913670
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPB5; XAP4; 25kDa; 2410021N14Rik
    Summary
    Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase II; and transcription elongation by RNA polymerase I. Predicted to be located in nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex and nuclear DNA-directed RNA polymerase complex. Is expressed in several structures, including branchial arch; embryo mesenchyme; maxillary process; nervous system; and sensory organ. Orthologous to human POLR2E (RNA polymerase II, I and III subunit E). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 144.4), placenta adult (RPKM 108.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Polr2e in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79871787..79875493, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80035953..80039659, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1805 Neighboring gene ATP-binding cassette, sub-family A member 7 Neighboring gene Rho GTPase activating protein 45 Neighboring gene STARR-positive B cell enhancer ABC_E2948 Neighboring gene STARR-positive B cell enhancer ABC_E6880 Neighboring gene STARR-seq mESC enhancer starr_27262 Neighboring gene STARR-positive B cell enhancer ABC_E900 Neighboring gene glutathione peroxidase 4 Neighboring gene strawberry notch 2 Neighboring gene STARR-seq mESC enhancer starr_27263

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Ding L, et al. Cell Stem Cell, 2009 May 8. PMID 19345177
    2. The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. Shimizu H, et al. PLoS One, 2013. PMID 24146773, Free PMC Article
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription elongation by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RPAP3/R2TP/prefoldin-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC1
    Names
    DNA-directed RNA polymerase II subunit E
    RNA polymerases I, II, and III subunit ABC1
    RPB5 homolog
    NP_079830.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025554.2 → NP_079830.2  DNA-directed RNA polymerases I, II, and III subunit RPABC1

      See identical proteins and their annotated locations for NP_079830.2

      Status: PROVISIONAL

      Source sequence(s)
      BC045521
      Consensus CDS
      CCDS35972.1
      UniProtKB/Swiss-Prot
      Q80UW8
      UniProtKB/TrEMBL
      Q3V214
      Related
      ENSMUSP00000004786.10, ENSMUST00000004786.10
      Conserved Domains (1) summary
      PLN03111
      Location:1 → 209
      PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79871787..79875493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UW8.1 GenPept UniProtKB/Swiss-Prot:Q80UW8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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