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    Stn1 STN1, CST complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 108689, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Stn1provided by MGI
    Official Full Name
    STN1, CST complex subunitprovided by MGI
    Primary source
    MGI:MGI:1915581
    See related
    Ensembl:ENSMUSG00000042694 AllianceGenome:MGI:1915581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AAF44; Obfc1; AAF-44; RPA-32; 0610009H20Rik; 2310057J23Rik
    Summary
    Enables single-stranded DNA binding activity and telomeric DNA binding activity. Involved in positive regulation of DNA replication. Located in chromosome, telomeric region and nucleus. Part of CST complex. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human STN1 (STN1 subunit of CST complex). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 8.0), CNS E11.5 (RPKM 7.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stn1 in Genome Data Viewer
    Location:
    19 C3; 19 39.64 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47489470..47534284, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47501031..47545845, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene SH3 and PX domains 2A Neighboring gene predicted gene, 52384 Neighboring gene STARR-seq mESC enhancer starr_46363 Neighboring gene predicted gene, 41858 Neighboring gene STARR-positive B cell enhancer ABC_E5709 Neighboring gene predicted gene, 19557 Neighboring gene STARR-seq mESC enhancer starr_46366 Neighboring gene STE20-like kinase Neighboring gene predicted gene 16068 Neighboring gene collagen, type XVII, alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair. Nguyen DD, et al. Sci Adv, 2023 May 10. PMID 37163605, Free PMC Article
    2. OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. Wan M, et al. J Biol Chem, 2009 Sep 25. PMID 19648609, Free PMC Article
    3. A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. Casteel DE, et al. J Biol Chem, 2009 Feb 27. PMID 19119139, Free PMC Article
    4. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Miyake Y, et al. Mol Cell, 2009 Oct 23. PMID 19854130
    5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
      Title: Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
    2. OBFC1 is identical to the previously described 44 kDa subunit of DNA-pol-alpha/primase associated factor (AAF) which increases polymerase-alpha/primase template affinity and stimulate both DNA primase and polymerase-alpha activities in vitro.
      Title: A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded telomeric DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in telomere capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via telomere lengthening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via telomere lengthening ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of CST complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CST complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CST complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CST complex subunit STN1
    Names
    alpha accessory factor 44
    alpha-accessory factor of 44 kDa
    oligonucleotide/oligosaccharide-binding fold containing 1
    oligonucleotide/oligosaccharide-binding fold-containing protein 1
    replication protein A 32 kDa subunit
    suppressor of cdc thirteen homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175360.3 → NP_780569.1  CST complex subunit STN1

      See identical proteins and their annotated locations for NP_780569.1

      Status: VALIDATED

      Source sequence(s)
      AC125075, AK075574, AK164386
      Consensus CDS
      CCDS29892.1
      UniProtKB/Swiss-Prot
      Q3TPH0, Q8C6I6, Q8K2X3
      Related
      ENSMUSP00000040944.9, ENSMUST00000049369.16
      Conserved Domains (2) summary
      cd04483
      Location:65 → 165
      hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...
      pfam09170
      Location:167 → 343
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47489470..47534284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250695.1 → XP_030106555.1  CST complex subunit STN1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TPH0, Q8C6I6, Q8K2X3
      Conserved Domains (2) summary
      cd04483
      Location:65 → 165
      hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...
      pfam09170
      Location:167 → 343
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1

    2. XM_006526598.4 → XP_006526661.1  CST complex subunit STN1 isoform X2

      See identical proteins and their annotated locations for XP_006526661.1

      UniProtKB/TrEMBL
      Q3UXU8
      Related
      ENSMUSP00000138727.2, ENSMUST00000182808.8
      Conserved Domains (2) summary
      cd04483
      Location:65 → 165
      hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...
      pfam09170
      Location:167 → 326
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2X3.2 GenPept UniProtKB/Swiss-Prot:Q8K2X3

    Gene LinkOut

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