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    Pknox2 Pbx/knotted 1 homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 208076, updated on 2-Nov-2024

    Summary

    Official Symbol
    Pknox2provided by MGI
    Official Full Name
    Pbx/knotted 1 homeobox 2provided by MGI
    Primary source
    MGI:MGI:2445415
    See related
    Ensembl:ENSMUSG00000035934 AllianceGenome:MGI:2445415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prep2; D230005H23Rik
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; actin filament binding activity; and actin monomer binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in cytoplasm; cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PKNOX2 (PBX/knotted 1 homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 26.9), cortex adult (RPKM 10.3) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pknox2 in Genome Data Viewer
    Location:
    9 A4; 9 20.7 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (36802278..37058637, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (36890979..37147342, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26787 Neighboring gene etoposide induced 2.4 mRNA Neighboring gene predicted gene 27219 Neighboring gene STARR-seq mESC enhancer starr_23786 Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene STARR-seq mESC enhancer starr_23787 Neighboring gene predicted gene, 34652 Neighboring gene VISTA enhancer mm577 Neighboring gene predicted gene, 34538 Neighboring gene STARR-seq mESC enhancer starr_23793 Neighboring gene predicted gene, 48716 Neighboring gene STARR-positive B cell enhancer mm9_chr9:36984672-36984973 Neighboring gene STARR-positive B cell enhancer ABC_E249 Neighboring gene STARR-seq mESC enhancer starr_23796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:37038155-37038413 Neighboring gene transmembrane protein 218 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 2 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein PKNOX2
    Names
    PBX/knotted homeobox 2
    homeobox protein PREP-2
    homeodomain containing transcription factor PREP2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029838.3NP_001025009.1  homeobox protein PKNOX2 isoform 1

      See identical proteins and their annotated locations for NP_001025009.1

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
      Consensus CDS
      CCDS22974.1
      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Related
      ENSMUSP00000035806.6, ENSMUST00000039674.13
      Conserved Domains (3) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:577
      gliding_GltG; adventurous gliding motility protein GltG
    2. NM_001424685.1NP_001411614.1  homeobox protein PKNOX2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
    3. NM_001424686.1NP_001411615.1  homeobox protein PKNOX2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
    4. NM_001424687.1NP_001411616.1  homeobox protein PKNOX2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
    5. NM_001424688.1NP_001411617.1  homeobox protein PKNOX2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
    6. NM_001424689.1NP_001411618.1  homeobox protein PKNOX2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
    7. NM_001424690.1NP_001411619.1  homeobox protein PKNOX2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
    8. NM_148950.4NP_683752.2  homeobox protein PKNOX2 isoform 1

      See identical proteins and their annotated locations for NP_683752.2

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
      Consensus CDS
      CCDS22974.1
      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Related
      ENSMUSP00000135581.2, ENSMUST00000177218.8
      Conserved Domains (3) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:577
      gliding_GltG; adventurous gliding motility protein GltG

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      36802278..37058637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154763.1XP_036010656.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:577
      gliding_GltG; adventurous gliding motility protein GltG
    2. XM_006510126.5XP_006510189.1  homeobox protein PKNOX2 isoform X1

      See identical proteins and their annotated locations for XP_006510189.1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:577
      gliding_GltG; adventurous gliding motility protein GltG
    3. XM_006510125.5XP_006510188.1  homeobox protein PKNOX2 isoform X1

      See identical proteins and their annotated locations for XP_006510188.1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:577
      gliding_GltG; adventurous gliding motility protein GltG
    4. XM_036154762.1XP_036010655.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:577
      gliding_GltG; adventurous gliding motility protein GltG
    5. XM_036154764.1XP_036010657.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:577
      gliding_GltG; adventurous gliding motility protein GltG
    6. XM_006510127.5XP_006510190.1  homeobox protein PKNOX2 isoform X1

      See identical proteins and their annotated locations for XP_006510190.1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:577
      gliding_GltG; adventurous gliding motility protein GltG
    7. XM_006510124.5XP_006510187.1  homeobox protein PKNOX2 isoform X1

      See identical proteins and their annotated locations for XP_006510187.1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:577
      gliding_GltG; adventurous gliding motility protein GltG