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    Exo5 exonuclease 5 [ Mus musculus (house mouse) ]

    Gene ID: 73172, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Exo5provided by MGI
    Official Full Name
    exonuclease 5provided by MGI
    Primary source
    MGI:MGI:1920422
    See related
    Ensembl:ENSMUSG00000028629 AllianceGenome:MGI:1920422
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dem1; Exo V; mExo5; 3110037I16Rik
    Summary
    Enables 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in interstrand cross-link repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human EXO5 (exonuclease 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.6), CNS E14 (RPKM 10.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Exo5 in Genome Data Viewer
    Location:
    4 D2.2; 4 56.65 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120778399..120782202, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120921202..120925005, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11258 Neighboring gene 60S ribosomal protein L26-like 1 pseudogene Neighboring gene predicted gene, 24678 Neighboring gene STARR-positive B cell enhancer ABC_E10254 Neighboring gene STARR-positive B cell enhancer ABC_E6207 Neighboring gene zinc finger protein 69 Neighboring gene STARR-positive B cell enhancer ABC_E6208 Neighboring gene STARR-positive B cell enhancer ABC_E4659 Neighboring gene small ArfGAP 2 Neighboring gene microRNA 7015

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exonuclease 5 is dispensable for meiotic progression and male fertility in mouse. Zaman Q, et al. Gene, 2021 Feb 15. PMID 33164760
    2. Human exonuclease 5 is a novel sliding exonuclease required for genome stability. Sparks JL, et al. J Biol Chem, 2012 Dec 14. PMID 23095756, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA 5'-3' DNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA 5'-3' DNA exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    exonuclease V
    Names
    defects in morphology 1 homolog
    defects in morphology protein 1 homolog
    probable exonuclease V

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160043.1 → NP_001153515.1  exonuclease V

      See identical proteins and their annotated locations for NP_001153515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK014134, CA548348
      Consensus CDS
      CCDS18596.1
      UniProtKB/Swiss-Prot
      A2A767, A2A769, Q9CXP9
      Related
      ENSMUSP00000136408.2, ENSMUST00000177880.2
      Conserved Domains (1) summary
      pfam09810
      Location:72 → 355
      Exo5; Exonuclease V - a 5' deoxyribonuclease

    2. NM_028457.2 → NP_082733.1  exonuclease V

      See identical proteins and their annotated locations for NP_082733.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK014134, CA548348
      Consensus CDS
      CCDS18596.1
      UniProtKB/Swiss-Prot
      A2A767, A2A769, Q9CXP9
      Related
      ENSMUSP00000030375.3, ENSMUST00000030375.9
      Conserved Domains (1) summary
      pfam09810
      Location:72 → 355
      Exo5; Exonuclease V - a 5' deoxyribonuclease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      120778399..120782202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXP9.1 GenPept UniProtKB/Swiss-Prot:Q9CXP9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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