Il1r1 interleukin 1 receptor, type I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il1r1provided by MGI
Official Full Name: interleukin 1 receptor, type Iprovided by MGI
Primary source: MGI:MGI:96545
See related: Ensembl:ENSMUSG00000026072 AllianceGenome:MGI:96545
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-iR; CD121a; CD121b; IL-1R1; Il1r-1; IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha
Summary: Enables interleukin-1 binding activity; interleukin-1 receptor activity; and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in aorta-gonad-mesonephros; brain; liver; spleen; and uterus. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis; systemic scleroderma; and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E18 (RPKM 5.6), bladder adult (RPKM 4.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 18.81 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (40261651..40355361)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (40222480..40316201)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4[+] T cell responses following COVID-19 mRNA vaccination.
Title: IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4(+) T cell responses following COVID-19 mRNA vaccination.
M1-Type Microglia-Derived Extracellular Vesicles Overexpressing IL-1R1 Promote Postoperative Cognitive Dysfunction by Regulating Neuronal Inflammation.
Title: M1-Type Microglia-Derived Extracellular Vesicles Overexpressing IL-1R1 Promote Postoperative Cognitive Dysfunction by Regulating Neuronal Inflammation.
IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury.
Title: IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury.
Cumulus Cells Accelerate Postovulatory Oocyte Aging through IL1-IL1R1 Interaction in Mice.
Title: Cumulus Cells Accelerate Postovulatory Oocyte Aging through IL1-IL1R1 Interaction in Mice.
IL-1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis.
Title: IL-1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis.
Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice.
Title: Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice.
The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.
Title: The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.
IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage.
Title: IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage.
IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
Title: IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress.
Title: Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress.

Submit: New GeneRIF Correction See all GeneRIFs (151)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit232 (e-PCR), detects polymorphism
- UniSTS:116251

Il1r1 (e-PCR), detects polymorphism
- UniSTS:525668

Il1r1 (e-PCR), detects polymorphism
- UniSTS:256684

RH94740 (e-PCR)
- UniSTS:119987

Il1r1 (e-PCR), detects polymorphism
- UniSTS:143544

Il1r1 (e-PCR), detects polymorphism
- UniSTS:143545

M20658 (e-PCR)
- UniSTS:178382

M20658 (e-PCR)
- UniSTS:124926

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables interleukin-1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-1 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-1 receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables interleukin-1 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-1, type I, activating receptor activity	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in heat acclimation	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-1-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of interleukin-1-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neutrophil extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-1 receptor type 1

Names: CD121 antigen-like family member A; IL-1 receptor alpha chain; interleukin-1 receptor alpha

NP_001116854.1

EC 3.2.2.6

NP_032388.1

EC 3.2.2.6

XP_006495776.1

EC 3.2.2.6

XP_006495777.1

EC 3.2.2.6

XP_006495785.1

EC 3.2.2.6

XP_006495786.1

EC 3.2.2.6

XP_030106479.1

EC 3.2.2.6

XP_036018058.1

EC 3.2.2.6

XP_036018071.1

EC 3.2.2.6

XP_036018078.1

EC 3.2.2.6

XP_036018079.1

EC 3.2.2.6

XP_036018081.1

EC 3.2.2.6

XP_036018088.1

EC 3.2.2.6

XP_036018090.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123382.2 → NP_001116854.1 interleukin-1 receptor type 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001116854.1

Status: VALIDATED

Source sequence(s)

AC135085, AC167168

Consensus CDS

CCDS48246.1

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Related

ENSMUSP00000110443.2, ENSMUST00000114795.3

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
NM_008362.3 → NP_032388.1 interleukin-1 receptor type 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_032388.1

Status: VALIDATED

Source sequence(s)

AC135085, AC167168

Consensus CDS

CCDS35547.1

UniProtKB/Swiss-Prot

P13504

UniProtKB/TrEMBL

Q32MH0, Q8C6P3

Related

ENSMUSP00000027241.5, ENSMUST00000027241.11

Conserved Domains (4) summary

smart00255
Location:387 → 542

TIR; Toll - interleukin 1 - resistance

cd05757
Location:131 → 220

Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

pfam13927
Location:229 → 319

Ig_3; Immunoglobulin domain

cl11960
Location:31 → 116

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

40261651..40355361

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495713.4 → XP_006495776.1 interleukin-1 receptor type 1 isoform X1

See identical proteins and their annotated locations for XP_006495776.1

UniProtKB/Swiss-Prot

P13504

UniProtKB/TrEMBL

Q32MH0, Q8C6P3

Conserved Domains (4) summary

smart00255
Location:387 → 542

TIR; Toll - interleukin 1 - resistance

cd05757
Location:131 → 220

Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

pfam13927
Location:229 → 319

Ig_3; Immunoglobulin domain

cl11960
Location:31 → 116

Ig; Immunoglobulin domain
XM_006495722.4 → XP_006495785.1 interleukin-1 receptor type 1 isoform X2

See identical proteins and their annotated locations for XP_006495785.1

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
XM_030250619.2 → XP_030106479.1 interleukin-1 receptor type 1 isoform X2

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
XM_036162185.1 → XP_036018078.1 interleukin-1 receptor type 1 isoform X2

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
XM_036162197.1 → XP_036018090.1 interleukin-1 receptor type 1 isoform X2

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
XM_036162186.1 → XP_036018079.1 interleukin-1 receptor type 1 isoform X2

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
XM_006495723.5 → XP_006495786.1 interleukin-1 receptor type 1 isoform X2

See identical proteins and their annotated locations for XP_006495786.1

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
XM_036162195.1 → XP_036018088.1 interleukin-1 receptor type 1 isoform X2

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
XM_036162178.1 → XP_036018071.1 interleukin-1 receptor type 1 isoform X2

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
XM_036162165.1 → XP_036018058.1 interleukin-1 receptor type 1 isoform X2

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
XM_006495714.5 → XP_006495777.1 interleukin-1 receptor type 1 isoform X2

See identical proteins and their annotated locations for XP_006495777.1

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain
XM_036162188.1 → XP_036018081.1 interleukin-1 receptor type 1 isoform X2

UniProtKB/TrEMBL

Q8C6P3, Q8C833

Conserved Domains (3) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:226 → 229

Ig; Ig strand A [structural motif]

cl11960
Location:226 → 329

Ig; Immunoglobulin domain