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    Trim7 tripartite motif-containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 94089, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Trim7provided by MGI
    Official Full Name
    tripartite motif-containing 7provided by MGI
    Primary source
    MGI:MGI:2137353
    See related
    Ensembl:ENSMUSG00000040350 AllianceGenome:MGI:2137353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in antiviral innate immune response. Located in cytoplasm and nucleus. Orthologous to human TRIM7 (tripartite motif containing 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 20.2), spleen adult (RPKM 18.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trim7 in Genome Data Viewer
    Location:
    11 B1.2; 11 28.8 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (48716965..48742019)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (48826138..48851192)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1822 Neighboring gene nuclear encoded tRNA valine 7 (anticodon CAC) Neighboring gene nuclear encoded tRNA glycine 1 (anticodon ACC) Neighboring gene cyclin dependent kinase 2 associated protein 1 retrotransposed Neighboring gene STARR-positive B cell enhancer ABC_E3945 Neighboring gene nuclear encoded tRNA lysine 10 (anticodon CTT) Neighboring gene nuclear encoded tRNA alanine 9 (anticodon TGC) Neighboring gene predicted gene 16170 Neighboring gene STARR-positive B cell enhancer ABC_E5220 Neighboring gene nuclear encoded tRNA threonine 2 (anticodon TGT) Neighboring gene nuclear encoded tRNA proline 4 (anticodon TGG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS. Yang B, et al. Front Immunol, 2021. PMID 34512666, Free PMC Article
    2. RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation. Yang B, et al. PLoS Pathog, 2020 Mar. PMID 32126128, Free PMC Article
    3. E3 ubiquitin ligase tripartite motif 7 positively regulates the TLR4-mediated immune response via its E3 ligase domain in macrophages. Lu M, et al. Mol Immunol, 2019 May. PMID 30928727
    4. GNIP1 E3 ubiquitin ligase is a novel player in regulating glycogen metabolism in skeletal muscle. Montori-Grau M, et al. Metabolism, 2018 Jun. PMID 29466708
    5. GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis. Skurat AV, et al. J Biol Chem, 2002 May 31. PMID 11916970

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
      Title: TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
    2. Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
      Title: Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
    3. findings suggested a novel function of RNF90 in innate immunity.
      Title: RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.
    4. TRIM7 may facilitate the TLR4-mediated innate response via its E3 ligase domain in macrophages.
      Title: E3 ubiquitin ligase tripartite motif 7 positively regulates the TLR4-mediated immune response via its E3 ligase domain in macrophages.
    5. GNIP1 is an ubiquitin ligase with a markedly glycogenic effect in skeletal muscle.
      Title: GNIP1 E3 ubiquitin ligase is a novel player in regulating glycogen metabolism in skeletal muscle.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM7
    Names
    glycogenin-interacting protein
    tripartite motif protein 7
    tripartite motif-containing protein 7
    NP_001334375.1
    NP_444396.2
    XP_006534631.1
    XP_006534632.1
    XP_006534634.1
    XP_006534636.1
    XP_006534637.1
    XP_006534638.1
    XP_006534639.1
    XP_006534640.1
    XP_011247635.1
    XP_017170349.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347446.1 → NP_001334375.1  E3 ubiquitin-protein ligase TRIM7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      AL645849
      Consensus CDS
      CCDS83797.1
      UniProtKB/Swiss-Prot
      Q5NCB6, Q923T7, Q99PQ5
      UniProtKB/TrEMBL
      Q5NCB7
      Related
      ENSMUSP00000039011.6, ENSMUST00000046903.6

    2. NM_053166.2 → NP_444396.2  E3 ubiquitin-protein ligase TRIM7 isoform 1

      See identical proteins and their annotated locations for NP_444396.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 1, which is shorter at the N-terminus, compared to isoform 2.
      Source sequence(s)
      AL645849
      Consensus CDS
      CCDS48779.1
      UniProtKB/Swiss-Prot
      Q923T7
      Related
      ENSMUSP00000104836.3, ENSMUST00000109213.9
      Conserved Domains (1) summary
      cd13740
      Location:137 → 303
      SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      48716965..48742019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534568.4 → XP_006534631.1  E3 ubiquitin-protein ligase TRIM7 isoform X1

      UniProtKB/Swiss-Prot
      Q5NCB6, Q923T7, Q99PQ5
      Conserved Domains (5) summary
      COG4942
      Location:255 → 357
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd13740
      Location:426 → 592
      SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
      cd00162
      Location:29 → 80
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19762
      Location:129 → 170
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
      cl17238
      Location:26 → 81
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_006534569.4 → XP_006534632.1  E3 ubiquitin-protein ligase TRIM7 isoform X2

      UniProtKB/Swiss-Prot
      Q5NCB6, Q923T7, Q99PQ5
      Conserved Domains (5) summary
      COG4942
      Location:254 → 356
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd13740
      Location:425 → 591
      SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
      cd00162
      Location:29 → 80
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19762
      Location:129 → 170
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
      cl17238
      Location:26 → 81
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_011249333.3 → XP_011247635.1  E3 ubiquitin-protein ligase TRIM7 isoform X6

      UniProtKB/TrEMBL
      B2RR25
      Conserved Domains (4) summary
      cd00162
      Location:29 → 80
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19762
      Location:129 → 170
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
      cl17238
      Location:26 → 81
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl21478
      Location:158 → 204
      ATP-synt_B; ATP synthase B/B' CF(0)

    4. XM_006534573.5 → XP_006534636.1  E3 ubiquitin-protein ligase TRIM7 isoform X4

      See identical proteins and their annotated locations for XP_006534636.1

      Conserved Domains (2) summary
      COG4942
      Location:33 → 135
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd13740
      Location:204 → 370
      SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

    5. XM_006534575.5 → XP_006534638.1  E3 ubiquitin-protein ligase TRIM7 isoform X5

      See identical proteins and their annotated locations for XP_006534638.1

      UniProtKB/Swiss-Prot
      Q923T7
      Conserved Domains (1) summary
      cd13740
      Location:137 → 303
      SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

    6. XM_006534577.5 → XP_006534640.1  E3 ubiquitin-protein ligase TRIM7 isoform X4

      See identical proteins and their annotated locations for XP_006534640.1

      Conserved Domains (2) summary
      COG4942
      Location:33 → 135
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd13740
      Location:204 → 370
      SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

    7. XM_006534576.4 → XP_006534639.1  E3 ubiquitin-protein ligase TRIM7 isoform X4

      See identical proteins and their annotated locations for XP_006534639.1

      Conserved Domains (2) summary
      COG4942
      Location:33 → 135
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd13740
      Location:204 → 370
      SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

    8. XM_017314860.2 → XP_017170349.1  E3 ubiquitin-protein ligase TRIM7 isoform X4

      Conserved Domains (2) summary
      COG4942
      Location:33 → 135
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd13740
      Location:204 → 370
      SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

    9. XM_006534571.4 → XP_006534634.1  E3 ubiquitin-protein ligase TRIM7 isoform X3

      Conserved Domains (2) summary
      COG4942
      Location:83 → 185
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd13740
      Location:254 → 420
      SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

    10. XM_006534574.5 → XP_006534637.1  E3 ubiquitin-protein ligase TRIM7 isoform X4

      See identical proteins and their annotated locations for XP_006534637.1

      Conserved Domains (2) summary
      COG4942
      Location:33 → 135
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd13740
      Location:204 → 370
      SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001347436.1: Suppressed sequence

      Description
      NM_001347436.1: This RefSeq was removed because the transcript was partial at the 5'' end, resulting in a partial CDS.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923T7.2 GenPept UniProtKB/Swiss-Prot:Q923T7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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