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    BNA7 arylformamidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852038, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BNA7
    Official Full Name
    arylformamidase
    Primary source
    SGD:S000002836
    Locus tag
    YDR428C
    See related
    AllianceGenome:SGD:S000002836; FungiDB:YDR428C; VEuPathDB:YDR428C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables arylformamidase activity. Involved in NAD biosynthetic process. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See BNA7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1323454..1324239, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Snx41p Neighboring gene proteasome regulatory particle lid subunit RPN9 Neighboring gene translation initiation factor eIF3 core subunit g Neighboring gene pitrilysin family metalloprotease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution. Arndt JW, et al. Proteins, 2005 Feb 15. PMID 15624212
    2. Identification of formyl kynurenine formamidase and kynurenine aminotransferase from Saccharomyces cerevisiae using crystallographic, bioinformatic and biochemical evidence. Wogulis M, et al. Biochemistry, 2008 Feb 12. PMID 18205391
    3. Yeast chemogenomic screen identifies distinct metabolic pathways required to tolerate exposure to phenolic fermentation inhibitors ferulic acid, 4-hydroxybenzoic acid and coniferyl aldehyde. Fletcher E, et al. Metab Eng, 2019 Mar. PMID 30471359
    4. Independent regulation of age associated fat accumulation and longevity. Beas AO, et al. Nat Commun, 2020 Jun 3. PMID 32493904, Free PMC Article
    5. Functional genetic discovery of enzymes using full-scan mass spectrometry metabolomics (1). Caudy AA, et al. Biochem Cell Biol, 2019 Feb. PMID 30001498

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae
      Title: Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables arylformamidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylformamidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arylformamidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tryptophan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    arylformamidase
    NP_010716.3
    • Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1323454..1324239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180736.3 → NP_010716.3  TPA: arylformamidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010716.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT57, Q04066
      UniProtKB/TrEMBL
      B3LFM9, B5VGW1, C7GTN4, C8Z5Y9, G2WBG3, N1P781
      Conserved Domains (1) summary
      COG0657
      Location:28 → 213
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04066.1

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