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    ldhba lactate dehydrogenase Ba [ Danio rerio (zebrafish) ]

    Gene ID: 30497, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ldhbaprovided by ZNC
    Official Full Name
    lactate dehydrogenase Baprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991026-6
    See related
    Ensembl:ENSDARG00000019644 AllianceGenome:ZFIN:ZDB-GENE-991026-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ldhb; LDH-B-A; wu:fa16d07; wu:fa20c10; wu:fa96a08
    Summary
    Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process and pyruvate metabolic process. Predicted to act upstream of or within carboxylic acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; musculature system; nervous system; pronephric duct; and yolk syncytial layer. Orthologous to human LDHB (lactate dehydrogenase B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ldhba in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (16829111..16835904, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (16840135..16846928, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene spexin hormone Neighboring gene glycogen synthase 2 Neighboring gene kisspeptin 2 Neighboring gene solute carrier family 25 member 3a Neighboring gene thymopoietin a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic analysis of vertebrate lactate dehydrogenase (LDH) multigene families. Li YJ, et al. J Mol Evol, 2002 May. PMID 11965434
    2. Lactate metabolism coordinates macrophage response and regeneration in zebrafish. Bohaud C, et al. Theranostics, 2022. PMID 35664055, Free PMC Article
    3. Global proteomics analysis of testis and ovary in adult zebrafish (Danio rerio). Groh KJ, et al. Fish Physiol Biochem, 2011 Sep. PMID 21229308, Free PMC Article
    4. Interacting Effects of Cell Size and Temperature on Gene Expression, Growth, Development and Swimming Performance in Larval Zebrafish. van de Pol ILE, et al. Front Physiol, 2021. PMID 34950046, Free PMC Article
    5. A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Li Z, et al. Dis Model Mech, 2013 Mar. PMID 23038063, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lactate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    L-lactate dehydrogenase B-A chain
    Names
    L-lactate dehydrogenase B chain
    LDH-B
    lactate dehydrogenase B4
    NP_571322.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131247.1 → NP_571322.1  L-lactate dehydrogenase B-A chain

      See identical proteins and their annotated locations for NP_571322.1

      Status: PROVISIONAL

      Source sequence(s)
      AF067202
      UniProtKB/Swiss-Prot
      Q9PVK4
      Related
      ENSDARP00000013329.6, ENSDART00000010777.7
      Conserved Domains (2) summary
      cd05293
      Location:19 → 330
      LDH_1; A subgroup of L-lactate dehydrogenases
      PLN02602
      Location:4 → 332
      PLN02602; lactate dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      16829111..16835904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9PVK4.4 GenPept UniProtKB/Swiss-Prot:Q9PVK4

    Gene LinkOut

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