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    mest mesoderm specific transcript [ Danio rerio (zebrafish) ]

    Gene ID: 30242, updated on 12-Sep-2024

    Summary

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    Official Symbol
    mestprovided by ZNC
    Official Full Name
    mesoderm specific transcriptprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991111-5
    See related
    Ensembl:ENSDARG00000032319 AllianceGenome:ZFIN:ZDB-GENE-991111-5
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    peg1; Zpeg1; peg1/mest
    Summary
    Predicted to enable catalytic activity. Predicted to be involved in regulation of lipid storage. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human MEST (mesoderm specific transcript). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See mest in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (15996234..16001215, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (15997479..16002460, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene urocortin 3, like Neighboring gene COPI coat complex subunit gamma 2 Neighboring gene uncharacterized LOC110439358 Neighboring gene uncharacterized LOC101884691 Neighboring gene uncharacterized LOC101884648

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structure and expression of the zebrafish mest gene, an ortholog of mammalian imprinted gene PEG1/MEST. Hahn Y, et al. Biochim Biophys Acta, 2005 Nov 10. PMID 16263186
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, we report identification of zebrafish (Danio rerio) gene mest, an ortholog of mammalian PEG1/MEST.
      Title: Structure and expression of the zebrafish mest gene, an ortholog of mammalian imprinted gene PEG1/MEST.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mesoderm-specific transcript homolog protein
    Names
    alpha/beta hydroxylase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328532.1 → NP_001315461.1  mesoderm-specific transcript homolog protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      CR749763
      UniProtKB/TrEMBL
      A0A8M1P9B6, Q1L8N8
      Related
      ENSDARP00000109634.2, ENSDART00000125389.4
      Conserved Domains (2) summary
      COG0596
      Location:55 → 342
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:78 → 164
      Abhydrolase; alpha/beta hydrolases

    2. NM_131043.2 → NP_571118.2  mesoderm-specific transcript homolog protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CR749763
      UniProtKB/TrEMBL
      A0A8N7UZF8, Q1L8N7
      Related
      ENSDARP00000041069.7, ENSDART00000041070.8

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      15996234..16001215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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