pparaa peroxisome proliferator-activated receptor alpha a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pparaaprovided by ZNC
Official Full Name: peroxisome proliferator-activated receptor alpha aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-169
See related: Ensembl:ENSDARG00000031777 AllianceGenome:ZFIN:ZDB-GENE-041210-169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ppara3; si:ch211-239e6.3
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Predicted to be involved in several processes, including negative regulation of cholesterol storage; positive regulation of fatty acid metabolic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; digestive system; heart; nervous system; and spinal cord neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (18607703..18649295, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (18618737..18660767, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPARalpha activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish.
Title: PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish.
Both pparaa and pparab are expressed in the developing central nervous system in zebrafish embryos. Both Pparalphaa and Pparalphab proteins are essential regulators of the proliferation of neuronal and glial precursors.
Title: Pparα deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peroxisome proliferator-activated receptor alpha a

Names: NR1C1-A; PPAR[a](III); PPARalpha-A; nr1c1a; peroxisome proliferator activated receptor alpha 3; ppara; ppara2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161333.1 → NP_001154805.1 peroxisome proliferator-activated receptor alpha a

See identical proteins and their annotated locations for NP_001154805.1

Status: VALIDATED

Source sequence(s)

BX649425

UniProtKB/TrEMBL

A0A8M1NRP3, F1Q684, Q5RGZ2

Related

ENSDARP00000107246.2, ENSDART00000125361.4

Conserved Domains (2) summary

cd06932
Location:199 → 469

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:98 → 181

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

18607703..18649295 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164753.5 → XP_005164810.1 peroxisome proliferator-activated receptor alpha a isoform X1

See identical proteins and their annotated locations for XP_005164810.1

UniProtKB/TrEMBL

A0A8M1NRP3, F1Q684, Q5RGZ2

Conserved Domains (2) summary

cd06932
Location:199 → 469

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:98 → 181

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers