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    PCK1 phosphoenolpyruvate carboxykinase 1 [ Gallus gallus (chicken) ]

    Gene ID: 396458, updated on 17-Aug-2024

    Summary

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    Symbol
    PCK1provided by CGNC
    Full Name
    phosphoenolpyruvate carboxykinase 1provided by CGNC
    Primary source
    CGNC:7308
    See related
    Ensembl:ENSGALG00010014946
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PEPCK
    Orthologs
    human mouse all
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    Genomic context

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    See PCK1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (11897159..11904819, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (11684387..11692012, complement)

    Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene prostate transmembrane protein, androgen induced 1 Neighboring gene uncharacterized LOC121111957 Neighboring gene uncharacterized LOC419322 Neighboring gene RNA binding motif protein 38 Neighboring gene uncharacterized LOC107054840 Neighboring gene ribonucleic acid export 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens. Duan J, et al. PLoS One, 2013. PMID 23544081, Free PMC Article
    2. Restriction fragment length and single strand conformational polymorphisms in chicken mitochondrial phosphoenol-pyruate carboxykinase gene and its association with egg production. Torkamanzehi A, et al. Pak J Biol Sci, 2007 Nov 15. PMID 19090282
    3. Inhibition of hepatic phosphoenolpyruvate carboxykinase by avian reticuloendotheliosis viruses. Garry RF, et al. Cancer Res, 1985 Oct. PMID 2992770
    4. Breed-dependent transcriptional regulation of phosphoenolpyruvate carboxylase, cytosolic form, expression in the liver of broiler chickens. Guo F, et al. Poult Sci, 2013 Oct. PMID 24046422
    5. Alleles of cytosolic phosphoenolpyruvate carboxykinase (PEPCK): trait association and interaction with mitochondrial PEPCK in a strain of White Leghorn chickens. Parsanejad R, et al. Poult Sci, 2003 Nov. PMID 14653465

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A fast-growing chicken breed had significantly higher hepatic mRNA expression levels of the cytosolic form of PEPCK and significantly higher hepatic mRNA and protein expression levels of cAMP response element binding protein 1.
      Title: Breed-dependent transcriptional regulation of phosphoenolpyruvate carboxylase, cytosolic form, expression in the liver of broiler chickens.
    2. Data indicate that aryl hydrocarbon receptor (AHR) enhances phosphoenolpyruvate carboxykinase (PEPCK) ADP-ribosylation through TiPARP TiPARP (TCDD-inducible poly(ADP-ribose) polymerase).
      Title: Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP).
    3. androgen status negatively regulated the PCK1 gene in male chickens.
      Title: Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.
    4. analysis of restriction fragment length and single strand conformational polymorphisms in chicken mitochondrial phosphoenol-pyruate carboxykinase gene and its association with egg production
      Title: Restriction fragment length and single strand conformational polymorphisms in chicken mitochondrial phosphoenol-pyruate carboxykinase gene and its association with egg production.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphoenolpyruvate carboxykinase (GTP) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycerol biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in propionate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoenolpyruvate carboxykinase, cytosolic [GTP]
    Names
    PEPCK-C
    cytosolic phosphoenolpyruvate carboxykinase
    phosphoenolpyruvate carboxykinase 1 (soluble)
    phosphoenolpyruvate carboxykinase, cytosolic
    phosphoenolpyruvate carboxylase
    serine-protein kinase PCK1
    NP_990802.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205471.2 → NP_990802.2  phosphoenolpyruvate carboxykinase, cytosolic [GTP]

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000328
      UniProtKB/Swiss-Prot
      P05153
      UniProtKB/TrEMBL
      F1NKP4
      Related
      ENSGALP00010020869.1, ENSGALT00010035950.1
      Conserved Domains (1) summary
      cd00819
      Location:27 → 615
      PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      11897159..11904819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      11684387..11692012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05153.1 GenPept UniProtKB/Swiss-Prot:P05153

    Gene LinkOut

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