ascl1a achaete-scute family bHLH transcription factor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ascl1aprovided by ZNC
Official Full Name: achaete-scute family bHLH transcription factor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-90
See related: Ensembl:ENSDARG00000038386 AllianceGenome:ZFIN:ZDB-GENE-980526-90
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ash; asha; zasha; zash1a; Zash-1a; id:ibd5085; im:7138587; si:dkey-264k15.2
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in adenohypophysis development; hindbrain morphogenesis; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including digestive tract development; nervous system development; and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including digestive system; nervous system; neural tube; neuronal stem cell; and optic cup. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (17417129..17418789)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (17428153..17429813)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The proneural factors Ascl1a and Ascl1b contribute to the terminal differentiation of dopaminergic GABAergic dual transmitter neurons in zebrafish.
Title: The proneural factors Ascl1a and Ascl1b contribute to the terminal differentiation of dopaminergic GABAergic dual transmitter neurons in zebrafish.
dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification
Title: The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon.
Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility
Title: Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility.
bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine
Title: The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine.
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt signaling inhibitor, Dkk, and induced expression of the Wnt ligand, Wnt4a.
Title: Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration.
The Ascl1a regulates Muller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway.
Title: Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway.
ascl1a is essential for retina regeneration: within 4 h after retinal injury, ascl1a is induced in Muller glia.
Title: The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration.
Cellular correlates of proneural gene(ash1a) expression in the regenerating zebrafish retina.
Title: Cellular correlates of proneural and Notch-delta gene expression in the regenerating zebrafish retina.
Ascl1a might act downstream of diencephalic fibroblast growth factor 3 (Fgf3) signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis
Title: The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis.

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General gene information

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Markers

ZASHA (e-PCR)
- UniSTS:205322

zash-a (e-PCR)
- UniSTS:204722

asha (e-PCR)
- UniSTS:238278

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenohypophysis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenohypophysis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell dedifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindbrain morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hindbrain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intestinal epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regeneration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory epithelium regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sensory epithelium regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sympathetic ganglion development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sympathetic ganglion development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within taste bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of tissue regeneration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: achaete-scute homolog 1a

Names: pia; pituitary absent; pituitary-absent protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131219.1 → NP_571294.1 achaete-scute homolog 1a

See identical proteins and their annotated locations for NP_571294.1

Status: PROVISIONAL

Source sequence(s)

U14587

UniProtKB/Swiss-Prot

Q90259

Related

ENSDARP00000056004.4, ENSDART00000056005.5

Conserved Domains (1) summary

cd19742
Location:75 → 145

bHLH_TS_ASCL1_Mash1; basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and similar proteins