ctsd cathepsin D [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ctsdprovided by ZNC
Official Full Name: cathepsin Dprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010131-8
See related: Ensembl:ENSDARG00000057698 AllianceGenome:ZFIN:ZDB-GENE-010131-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: catD; wu:fb93e11; wu:fj17b09
Summary: Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within muscle structure development; response to bacterium; and retinal pigment epithelium development. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including eye; liver; muscle; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (16133600..16146720)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (16144534..16157654)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first report showing a congenital myopathy caused by CD deficiency in a vertebrate experimental animal model.
Title: Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy.
phenotypic description of the lack of CD expression during zebrafish (Danio rerio) development
Title: Knock-down of cathepsin D affects the retinal pigment epithelium, impairs swim-bladder ontogenesis and causes premature death in zebrafish.

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General gene information

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Markers

fb93e11.x1 (e-PCR)
- UniSTS:191794

fb93e11.x1 (e-PCR)
- UniSTS:191795

fi42g08.x1 (e-PCR)
- UniSTS:197512

fc65f11.y1 (e-PCR)
- UniSTS:194205

AW184645 (e-PCR)
- UniSTS:205749

fj17b09.y1 (e-PCR)
- UniSTS:198654

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within muscle structure development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinal pigment epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cathepsin D

Names: LAP; etID16901.18

NP_571785.2

EC 3.4.23.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.