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    hbegfa heparin-binding EGF-like growth factor a [ Danio rerio (zebrafish) ]

    Gene ID: 797938, updated on 28-Oct-2024

    Summary

    Official Symbol
    hbegfaprovided by ZNC
    Official Full Name
    heparin-binding EGF-like growth factor aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-119
    See related
    Ensembl:ENSDARG00000075121 AllianceGenome:ZFIN:ZDB-GENE-080204-119
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:175091
    Summary
    Predicted to enable epidermal growth factor receptor binding activity and growth factor activity. Acts upstream of or within response to wounding; retina development in camera-type eye; and sensory epithelium regeneration. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in retina. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See hbegfa in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (7048993..7051940)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (6742266..6745213)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E binding protein 3, like Neighboring gene heterogeneous nuclear ribonucleoprotein H1 Neighboring gene RUN and FYVE domain containing 1 Neighboring gene si:ch73-43g23.1 Neighboring gene tRNA phosphotransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heparin-binding EGF-like growth factor a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111226.1NP_001104696.1  heparin-binding EGF-like growth factor a precursor

      See identical proteins and their annotated locations for NP_001104696.1

      Status: PROVISIONAL

      Source sequence(s)
      BC155826
      UniProtKB/TrEMBL
      A0A8N1YYX8, A9JRW9
      Related
      ENSDARP00000099541.3, ENSDART00000109138.4
      Conserved Domains (1) summary
      PHA02887
      Location:130170
      PHA02887; EGF-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      7048993..7051940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)