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    aldh16a1 aldehyde dehydrogenase 16 family, member A1 [ Danio rerio (zebrafish) ]

    Gene ID: 492710, updated on 2-Nov-2024

    Summary

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    Official Symbol
    aldh16a1provided by ZNC
    Official Full Name
    aldehyde dehydrogenase 16 family, member A1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070112-2062
    See related
    Ensembl:ENSDARG00000037935 AllianceGenome:ZFIN:ZDB-GENE-070112-2062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7151472; zgc:158277
    Summary
    Predicted to enable oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Is expressed in several structures, including intermediate cell mass of mesoderm; liver; neural tube; spinal cord; and vasculature. Orthologous to human ALDH16A1 (aldehyde dehydrogenase 16 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See aldh16a1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (32080359..32098537)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (31948626..31966823)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490638 Neighboring gene BCL2 associated X, apoptosis regulator b Neighboring gene ferritin, heavy polypeptide-like 27 Neighboring gene ferritin, heavy polypeptide-like 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ALDH2 mediates 5-nitrofuran activity in multiple species. Zhou L, et al. Chem Biol, 2012 Jul 27. PMID 22840776, Free PMC Article
    2. Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Brunsdon H, et al. Development, 2022 May 15. PMID 35485397, Free PMC Article
    3. ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Lu Y, et al. Cell Rep, 2024 Jul 23. PMID 38963759, Free PMC Article
    4. A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Ma AC, et al. Leukemia, 2010 Dec. PMID 20927131
    5. Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Lou B, et al. Redox Biol, 2020 Oct. PMID 32980661, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC158277

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase family 16 member A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079954.2 → NP_001073423.2  aldehyde dehydrogenase family 16 member A1

      Status: VALIDATED

      Source sequence(s)
      BX511080
      UniProtKB/TrEMBL
      A0A8N1TQ55, F1QGP1
      Related
      ENSDARP00000111827.2, ENSDART00000124943.3
      Conserved Domains (2) summary
      COG1012
      Location:514 → 755
      AdhE; Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Energy production and conversion]
      cl11961
      Location:18 → 470
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      32080359..32098537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164021.5 → XP_005164078.1  aldehyde dehydrogenase family 16 member A1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBC0
      Conserved Domains (2) summary
      COG1012
      Location:513 → 754
      AdhE; Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Energy production and conversion]
      cl11961
      Location:18 → 469
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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