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    rack1 receptor for activated C kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 30722, updated on 28-Oct-2024

    Summary

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    Official Symbol
    rack1provided by ZNC
    Official Full Name
    receptor for activated C kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-89
    See related
    Ensembl:ENSDARG00000041619 AllianceGenome:ZFIN:ZDB-GENE-990415-89
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gnb2l1; wu:fb80d08; wu:fk65d12
    Summary
    Predicted to enable protein kinase C binding activity and ribosome binding activity. Involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of gastrulation; and regulation of establishment of cell polarity. Acts upstream of or within angiogenesis and convergent extension involved in gastrulation. Located in cytoplasm. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human RACK1 (receptor for activated C kinase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rack1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (6946681..6953678)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (6639954..6646951)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(XXIII) chain-like Neighboring gene uncharacterized LOC137487510 Neighboring gene CDC-like kinase 4a Neighboring gene heterogeneous nuclear ribonucleoprotein A/Ba Neighboring gene NME/NM23 family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Isolation of Complementary DNAs Coding for a Receptor for Activated C Kinase (RACK) from Zebrafish (Danio rerio) and Tilapia (Oreochromis niloticus): Constitutive Developmental and Tissue Expression. Hamilton LC, et al. Mar Biotechnol (NY), 1999 May. PMID 10384002
    2. Histopathologic alterations associated with global gene expression due to chronic dietary TCDD exposure in juvenile zebrafish. Liu Q, et al. PLoS One, 2014. PMID 24988445, Free PMC Article
    3. Characterization of a member of the CEACAM protein family as a novel marker of proton pump-rich ionocytes on the zebrafish epidermis. Kowalewski J, et al. PLoS One, 2021. PMID 34252160, Free PMC Article
    4. Increased functional protein expression using nucleotide sequence features enriched in highly expressed genes in zebrafish. Horstick EJ, et al. Nucleic Acids Res, 2015 Apr 20. PMID 25628360, Free PMC Article
    5. RACK1 suppresses gastric tumorigenesis by stabilizing the β-catenin destruction complex. Deng YZ, et al. Gastroenterology, 2012 Apr. PMID 22240482

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rack1 has a dominant-negative effect on Vangl2 localization and gastrulation.
      Title: Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translational frameshifting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein RACK1
    Names
    RACK
    guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
    guanine nucleotide-binding protein subunit beta-2-like 1
    receptor for activated protein kinase C
    receptor of activated protein kinase C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131444.1 → NP_571519.1  small ribosomal subunit protein RACK1

      See identical proteins and their annotated locations for NP_571519.1

      Status: PROVISIONAL

      Source sequence(s)
      AF025330
      UniProtKB/Swiss-Prot
      O42248
      Related
      ENSDARP00000061000.3, ENSDART00000061001.5
      Conserved Domains (3) summary
      COG2319
      Location:10 → 310
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:8 → 311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:18 → 61
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      6946681..6953678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O42248.1 GenPept UniProtKB/Swiss-Prot:O42248

    Gene LinkOut

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