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    TXK TXK tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 7294, updated on 11-Apr-2024

    Summary

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    Official Symbol
    TXKprovided by HGNC
    Official Full Name
    TXK tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:12434
    See related
    Ensembl:ENSG00000074966 MIM:600058; AllianceGenome:HGNC:12434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RLK; TKL; BTKL; PTK4; PSCTK5
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein autophosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lymph node (RPKM 5.7), spleen (RPKM 3.3) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TXK in Genome Data Viewer
    Location:
    4p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (48066393..48134250, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (48033459..48101082, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48068410..48136267, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927157 Neighboring gene cyclic nucleotide gated channel subunit alpha 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:48013506-48014020 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:48014021-48014534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:48018379-48018880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21535 Neighboring gene NIPA like domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21536 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:48095793-48096992 Neighboring gene uncharacterized LOC124900886 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:48114113-48115312 Neighboring gene RNA, U6 small nuclear 838, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:48129156-48130018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21537 Neighboring gene Sharpr-MPRA regulatory region 15119 Neighboring gene NANOG hESC enhancer GRCh37_chr4:48177274-48177775 Neighboring gene tec protein tyrosine kinase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:48187797-48188522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15405 Neighboring gene uncharacterized LOC105374445 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:48293363-48294358

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. Suzuki N, et al. Clin Med Res, 2006 Jun. PMID 16809408, Free PMC Article
    2. TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12. Haire RN, et al. Hum Mol Genet, 1994 Jun. PMID 7951233
    3. Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694. Zhong Y, et al. J Biol Chem, 2015 Mar 6. PMID 25593320, Free PMC Article
    4. Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. Kashiwakura J, et al. Biol Pharm Bull, 2002 Jun. PMID 12081135
    5. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. Kashiwakura J, et al. J Exp Med, 1999 Oct 18. PMID 10523612, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.
      Title: Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Itk and Txk exert their effects on T helper (Th) cell differentiation and function at the level of expression; transgenic Txk is not a specific regulator of Th1 responses.
      Title: Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
    6. Th1 cells expressing Txk and Th1-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease.
      Title: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease.
    7. fuctions as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription
      Title: Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC22473

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in activation of phospholipase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase TXK
    Names
    PTK4 protein tyrosine kinase 4
    protein-tyrosine kinase 4
    resting lymphocyte kinase
    NP_003319.2
    XP_011512049.1
    XP_011512050.1
    XP_016864070.1
    XP_024309968.1
    XP_047272078.1
    XP_047272079.1
    XP_047272081.1
    XP_054206748.1
    XP_054206749.1
    XP_054206750.1
    XP_054206751.1
    XP_054206752.1
    XP_054206753.1
    XP_054206754.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003328.3 → NP_003319.2  tyrosine-protein kinase TXK

      Status: VALIDATED

      Source sequence(s)
      AC096749, DB103575, L27071
      Consensus CDS
      CCDS3480.1
      UniProtKB/Swiss-Prot
      P42681, Q14220
      UniProtKB/TrEMBL
      E7EQN8
      Related
      ENSP00000264316.4, ENST00000264316.9
      Conserved Domains (3) summary
      cd05059
      Location:266 → 521
      PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
      cd10398
      Location:143 → 248
      SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
      cd11907
      Location:85 → 139
      SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      48066393..48134250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008581.3 → XP_016864070.1  tyrosine-protein kinase TXK isoform X3

      UniProtKB/TrEMBL
      E7EQN8

    2. XM_011513747.4 → XP_011512049.1  tyrosine-protein kinase TXK isoform X2

      UniProtKB/TrEMBL
      E7EQN8
      Conserved Domains (4) summary
      cd05059
      Location:247 → 502
      PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
      cd10398
      Location:131 → 229
      SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
      pfam07714
      Location:252 → 499
      Pkinase_Tyr; Protein tyrosine kinase
      cl17036
      Location:88 → 130
      SH3; Src Homology 3 domain superfamily

    3. XM_024454200.2 → XP_024309968.1  tyrosine-protein kinase TXK isoform X1

      UniProtKB/TrEMBL
      E7EQN8
      Conserved Domains (3) summary
      cd05059
      Location:269 → 524
      PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
      cd10398
      Location:146 → 251
      SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
      cd11907
      Location:88 → 142
      SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)

    4. XM_047416123.1 → XP_047272079.1  tyrosine-protein kinase TXK isoform X5

    5. XM_011513748.4 → XP_011512050.1  tyrosine-protein kinase TXK isoform X6

      Conserved Domains (2) summary
      pfam07714
      Location:33 → 280
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:28 → 287
      PKc_like; Protein Kinases, catalytic domain

    6. XM_047416122.1 → XP_047272078.1  tyrosine-protein kinase TXK isoform X4

    7. XM_047416125.1 → XP_047272081.1  tyrosine-protein kinase TXK isoform X7

    RNA

    1. XR_007057955.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      48033459..48101082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350775.1 → XP_054206750.1  tyrosine-protein kinase TXK isoform X3

    2. XM_054350774.1 → XP_054206749.1  tyrosine-protein kinase TXK isoform X2

    3. XM_054350773.1 → XP_054206748.1  tyrosine-protein kinase TXK isoform X1

    4. XM_054350777.1 → XP_054206752.1  tyrosine-protein kinase TXK isoform X5

    5. XM_054350778.1 → XP_054206753.1  tyrosine-protein kinase TXK isoform X6

    6. XM_054350776.1 → XP_054206751.1  tyrosine-protein kinase TXK isoform X4

    7. XM_054350779.1 → XP_054206754.1  tyrosine-protein kinase TXK isoform X7

    RNA

    1. XR_008487028.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42681.3 GenPept UniProtKB/Swiss-Prot:P42681

    Gene LinkOut

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